Biomedical subjects

C Benavides

Publications and source records attributed to C Benavides.

5 recordsLinked to original sources

PubMed2005

Rabbit antithymocyte globulin: a postoperative risk factor for sirolimus-treated renal transplant patients?

AIMS: Randomized controlled studies suggest an increased incidence of perioperative wound complications among sirolimus-treated renal transplant patients. The present study analyzed the effect of rabbit antithymocyte globulin (rATG) on these postoperative complications. METHODS: Four hundred and twelve renal transplants were performed and managed postoperatively at two University-affiliated hospitals between January 1, 2001, and December 31, 2003. The patients received corticosteroids and Sirolimus, with delayed introduction of cyclosporine when the serum creatinine had decreased below 2.5 mg/dL. Two groups of patients were discriminated: group 1 received Basiliximab 20 mg on day 0 and day 4 (n = 283); group 2 recipients with a high panel of reactive antibody (PRA > 20%) and retransplant patients received rATG for induction (n = 129) for a maximum of 2 weeks postoperatively. The incidence of rejection was 14.5% for group 1 vs. 8.5% for group 2 patients. To avoid confounding variable associated with the rejection treatment, any patient with rejection was excluded for statistical analysis, as were patients with follow- up less than 30 days. The final study group for analysis included 350 patients: 235 with Basiliximab induction (group 1) and 115 rATG induction (group 2). The mean follow-up was 21.8 +/- 11 months. Differences in the incidences of postoperative hernia, wound infections, or lymphoceles requiring any form of drainage were analyzed for statistical significance using the chi-square test. RESULTS: The percentage of patients with wound complications was 26.0% versus 39.1% (P < .025) for group 1 versus group 2, respectively. Incisional hernias occurred in 10.6% versus 18.3% patients (P < .05), wound infections in 11.1% versus 16.5% (P = NS), and lymphoceles in 10.6% versus 15.9% (P = NS) for the two groups, respectively. CONCLUSIONS: rATG-induced renal transplants recipients treated with sirolimus, cyclosporine, and steroids show a significantly increased incidence of postoperative incisional hernias and a trend toward a greater number of lymphocele and wound infection complications.

Adult↗

PubMed2000

Nurse practitioner students in Nicaragua.

Despite the growing interest in enhancing the cultural awareness for nurse practitioner (NP) students who work with patients from the developing world, there is a dearth of reports on such experiences. This report describes the clinical experiences of NP students from George Mason University (Fairfax, VA) during an intensive 2 weeks in Nicaragua in their final semester, accompanied by an NP faculty member. The program was planned and implemented in collaboration with the Universidad Politecnica de Nicaragua School of Nursing (Managua, Nicaragua). The students' clinical experiences included working in a Health Post and an impoverished community. Students learned to manage clinical problems using minimal resources and acquired an appreciation for the cultural, political, and economic situations from which many of their patients in the United States originate. Recommendations for establishing this type of experience are included.

Attitude of Health Personnel↗

PubMed1999

Increasing accuracy and decreasing latency during clean intermittent self-catheterization procedures with young children.

We examined the effects of simulation training on performance of clean intermittent self-catheterization procedures with 2 young girls. Simulation training was conducted, after which independent performance was assessed within a multiple baseline design. The training resulted in increased accuracy and decreased latency for both girls.

Child, Preschool↗

PubMed1995

[Active labour management in primiparas. Prospective study].

The objective of our study was prospectively compare the effect in the rate of cesarean section of active labor management and of traditional labor management in primiparas with physiological term pregnancy. From september 1, 1993 to may 31, 1994, 145 primiparas with physiological term pregnancy were randomly assigned to one group of active labor management (study group, n = 75) and to one group of traditional labor management (control group, n = 70). Cesarean section rate was 9.3% in the study group and 20% in the control group (p < 0.05). There was no increase in fetal morbidity or mortality. Active labor management can reduce cesarean section rate in primiparas with physiological term pregnancy.

Adult↗

PubMed1994

[Induction of fetal lung maturity with combined hormonal therapy in premature labor].

Thyrotropin Releasing Hormone (THR) induce fetal pulmonary maturation by direct stimulation, and increase of fetal T3 and T4 which produce biochemical and structural pulmonary maturation. To evaluate the effectivity of TRH associated to corticoides in the prevention of respiratory distress syndrome (RDS) in premature labor, we administered TRH plus Cidoten to patients with imminent premature labor and gestational age (GA) < or = 32 weeks. In a total of 12 patients, tolerance was good in 85% (n = 10), birthweight was 1.782 +/- 488 g (x +/- 2 SD). RDS incidence of only 15.3% and chronic lung disease (CLD) incidence = 0. Newborn of mothers treated with TRH plus corticoids form in evident premature labor in our unit, showed laser rates of RDS and CLD than the described in literature for newborn of similar weight and GA treated only with corticoids.

Drug Therapy, Combination↗