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Biomedical subjects

C Bench

Publications and source records attributed to C Bench.

4 recordsLinked to original sources
PubMed1996

Psychopharmacology--in vivo neurochemistry and pharmacology.

Positron emission tomography (PET) and single photon emission computerized tomography (SPECT) brain imaging techniques are powerful tools for the investigation of human neurochemistry and psychopharmacology. These versatile in vivo methods can be used to measure brain receptor populations in psychiatric illness, to determine receptor occupancy and tissue pharmacokinetics of psychotropic drugs and to examine the functional effects of drug-induced neurotransmitter manipulation. This chapter reviews recent innovative basic and clinical studies, of relevance to psychiatry, and discusses methodological developments that extend the use of these techniques.

Brain↗
PubMed1993

Functional mapping of brain areas implicated in auditory--verbal memory function.

Positron emission tomography measurements of regional cerebral blood flow (rCBF) were performed in normal volunteers during two auditory--verbal memory tasks: a subspan and supraspan task. The difference in rCBF between tasks was used to identify brain areas/systems involved in auditory--verbal long-term memory. Increases in rCBF were observed in the left and right prefrontal cortex, precuneus and the retrosplenial area of the cingulate gyrus. Decreases in blood flow were centred in the superior temporal gyrus bilaterally. Separate comparisons were also made between each span task and a resting state. Brain regions showing increases in rCBF in these comparisons included the thalamus, left anterior cingulate, right parahippocampal gyrus, cerebellum and the superior temporal gyrus. The brain areas identified in these comparison define a number of the neuroanatomical components of a distributed system for signal processing and storage relevant to auditory--verbal memory function.

Adult↗
PubMed1992

Effect of the 5-HT1A partial agonist buspirone on regional cerebral blood flow in man.

Repeated measurements of regional cerebral blood flow (rCBF) were made in normal volunteers before, and after, the administration of the 5-HT1A partial agonist, buspirone, or placebo. The difference in rCBF, before and after drug, (buspirone versus placebo) was used to identify brain areas affected by buspirone. Buspirone-induced changes in rCBF were studied under two behavioural conditions (5 word-list learning and 15 word-list learning). Compared to placebo, buspirone increased blood flow in the cuneus during both behavioural states. However, decreases in blood flow, centred in the left dorso-lateral prefrontal cortex and posterior cingulate cortex, were only observed under one of the two behavioural conditions. It is concluded that buspirone-induced alterations in regional cerebral blood flow are better understood, not in relation to the known distribution of monoamine neurotransmitter systems (particularly ascending 5-HT projections), but rather in relation to putative neuronal circuits possibly many synapses "downstream" of buspirone's pharmacological site of action.

Adult↗