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Biomedical subjects

C Bengtsson

Publications and source records attributed to C Bengtsson.

At least 181 records · Page 10Linked to original sources
PubMed1985

Menopausal age and risk of cardiovascular disease and death. A 12-year follow-up of participants in the population study of women in Gothenburg, Sweden.

A longitudinal population study of 1462 women initially aged 38-60 has been proceeding in Gothenburg, Sweden since 1968. The results presented in this paper deal with menopausal age in relation to cardiovascular disease and overall mortality and refer to the initial 12-year follow-up period. The risk ratios concerning early menopausal age for all the various cardiovascular end-points studied were increased, except for new events of ECG changes suggestive of ischaemic heart disease. However, none of the risk ratios studied between menopausal age on the one hand and the 12-year incidences of myocardial infarction, angina pectoris, or stroke, on the other, was significantly increased when women who had reached the menopause at the age of 40, 45, or 50 were compared with the rest of the participants in the population study. When early menopause was related to the overall mortality, the risk ratio was increased only for women who had reached the menopause at the age of 50, but not sufficiently to be statistically significant. When reviewing the literature, it is obvious that the results from previous studies are discrepant and do not permit of any generalized conclusion as to whether there is a correlation between early menopause and ischaemic heart disease or not. Nor is our longitudinal study conclusive in this respect.

Adult↗
PubMed1985

Relationships between the menopause and risk factors for ischaemic heart disease.

There are still contradictory opinions as to whether there is an association between menopausal age and ischaemic heart disease or not. There is, however, no doubt about the existence of a number of relationships between menstrual status and different risk factors for ischaemic heart disease. Thus, smoking will give rise to an earlier menopause, while the menopause will give rise to increased serum cholesterol and serum triglyceride levels but seems to influence arterial blood pressure and body weight in the opposite way. The relationships between the menopause and risk factors for ischaemic heart disease are complex, which may be one reason for the contradictory results when relating menopausal age to the incidence of ischaemic heart disease.

Blood Pressure↗
PubMed1985

Hypergastrinemia--a risk factor for myocardial infarction?

We determined gastrin and pepsinogen I in serum samples obtained in 1968-69 from 256 women (175 women 54 years old and 81 women 60 years old when sampled). The concentration of gastrin in serum was significantly (p less than 0.01) and positively correlated with the incidence of myocardial infarction during a 12-year follow-up, with age taken into account as a background variable in multivariate analysis. It was not correlated with overall mortality or with the 12-year incidences of angina pectoris, electrocardiographic changes indicating ischemic heart disease, or stroke. The correlation with myocardial infarction was independent of smoking, systolic blood pressure, indices of obesity, concentrations of blood glucose during fasting and of serum triglycerides and cholesterol, and of the presence of diabetes mellitus at screening or during follow-up. Serum gastrin was significantly (p less than 0.05) related to body mass index (positive age-specific relation) and to smoking (negative age-specific relation). These findings may provide a new aspect to analysis of risk factors for myocardial infarction.

Adult↗
PubMed1985

On the natural history of hypergastrinemia.

We determined total gastrin and pepsinogen I in frozen serum samples from 175 overnight-fasted women 54 years old, and from 81 overnight-fasted women 60 years old, who took part in a population study in 1968-69. We also assayed samples from some of these women, who participated in clinical follow-up studies in 1974-75 and 1980-81: all of the women in the initial group whose serum gastrin concentration exceeded the 85th centile value and, as a reference group, a randomized subsample of women whose initial serum gastrin concentration was less than the 80th centile. Samples with total gastrin concentration greater than 400 ng/L were also assayed for gastrin-17 and gastrin-34. We found that: a pronounced increase of serum gastrin persisted throughout the study period for most of these postmenopausal women, indicating that conversion of type A gastritis (antrum-sparing) to pan-gastritis is uncommon; unexplained high concentrations of pepsinogen I in relation to the reference interval for young and middle-aged adults, as well as in relation to serum gastrin, were common; and the gastrin-17/gastrin-34 ratio is not correlated with the outcome of pronounced hypergastrinemia.

Achlorhydria↗
PubMed1984

Do antihypertensive drugs precipitate diabetes?

A longitudinal population study of 1462 women aged 38-60 was carried out from 1968-9 to 1980-1 in Gothenburg, Sweden. The initial and follow up examinations included questions concerning history of diabetes and antihypertensive treatment. A considerably increased risk of developing diabetes was observed for subjects with hypertension taking diuretics (895 patient years), subjects taking beta blockers (682 patient years), and subjects taking a combination of diuretics and beta blockers (281 patient years) compared with subjects not taking antihypertensive drugs (13 855 control years). When diuretics and beta blockers were compared no difference was found in relative risk. Despite this increased risk, and because little is known about the relation between other forms of antihypertensive treatment and diabetes, diuretics and beta blockers should remain the treatments of choice in arterial hypertension.

Adrenergic beta-Antagonists↗
PubMed1984

Distribution of adipose tissue and risk of cardiovascular disease and death: a 12 year follow up of participants in the population study of women in Gothenburg, Sweden.

A longitudinal population study of 1462 women aged 38-60 was carried out in Gothenburg, Sweden, in 1968-9. In univariate analysis the ratio of waist to hip circumference showed a significant positive association with the 12 year incidence of myocardial infarction, angina pectoris, stroke, and death. The association with incidence of myocardial infarction remained in multivariate analysis and was independent of age, body mass index, smoking habit, serum cholesterol concentration, serum triglyceride concentration, and systolic blood pressure. The relation between the ratio of waist to hip circumference and the end points of myocardial infarction, angina pectoris, stroke, and death was stronger than for any other anthropometric variable studied.

Adipose Tissue↗
PubMed1984

Impairment of physical performance after treatment with beta blockers and alpha blockers.

An investigation was made into the effect of various types of beta blockers, an alpha blocker, a combined alpha and beta blocker, and a diuretic on physical performance in a normotensive man. Beta blockers, the alpha blocker, and the combined alpha and beta blocker significantly (p less than 0.001) reduced physical performance. Further studies are needed to confirm these findings in a larger series of subjects.

Adrenergic alpha-Antagonists↗
PubMed1984

Pafenolol, a new beta 1-selective blocking agent, in mild hypertension. Result of an inpatient study and a subsequent outpatient follow-up.

Pafenolol, a new selective adrenergic beta 1-blocking agent, has been tested for the first time in 6 hypertensive patients. After single oral doses of pafenolol 25 to 100 mg, there was a marked reduction in heart rate and systolic blood pressure during exercise tests. These effects were dose dependent. A significant positive correlation was found between the reduction in heart rate during exercise and the plasma level of pafenolol 5 hours after drug intake (correlation coefficient r = 0.94). Side effects were mild and seemed to be dose dependent. It is concluded that this new beta 1-blocking agent was effective in reducing blood pressure and was well tolerated.

Adrenergic beta-Antagonists↗
PubMed1984

Short-term effects of felodipine, a new dihydropyridine, in hypertension.

Felodipine, a dihydropyridine, is a new vasodilating calcium antagonist which lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. The effects on BP, heart rate (HR) and tolerance of different single oral doses of felodipine were studied in two series of hypertensive patients. When felodipine was given as single drug to 14 previously untreated hypertensives in a single-blind manner, BP was rapidly reduced by about 15% while HR increased by 25%. Felodipine given in a double-blind manner to eight patients on chronic beta-adrenoceptor blockade reduced BP by some 15-20% compared to placebo, while HR did not change. There was a significant correlation between the pre-treatment mean arterial BP (MAP) and the maximal relative change in MAP, i.e. the higher the initial BP the greater the reduction after felodipine. A significant correlation was also found between the plasma concentration of felodipine and the relative change in MAP. Felodipine was generally well tolerated. When given alone felodipine caused the side effects expected from a pure vasodilator, i.e. headache, flushing and palpitations. When given together with a beta-adrenoceptor blocker, the side effects were much less apparent.

Adult↗
PubMed1984

Serum triiodothyronine and hyperthyroidism in a population sample of women.

The serum T3 assay has been regarded as the most sensitive single test for hyperthyroidism although impaired conversion of T4 to T3 in non-thyroidal illness (NTI) might decrease its diagnostic sensitivity. The present report gives experience from the T3 assay in middle-aged females under conditions similar to those in a general health survey. The assays were performed during two periods with an interval of six years. In 1974-75 we studied a representative sample (n = 1283) of women of ages 44, 52, 56, 60 and 66 years in Göteborg, Sweden. Individuals with serum T3 concentration greater than mean + 2.5 SD were selected for a follow-up study (n = 21). Of 16 individuals with no previous thyroid disease and no present treatment with thyroid hormones or oestrogens, 14 were subjected to a TRH-stimulation test giving a normal TSH response in 10 cases having T3 concentrations up to mean + 3.5 SD. Four women with serum T3 concentration greater than or equal to mean + 3.5 SD had previously unrecognized autonomous function thyroid function, of whom two developed hyperthyroidism after two years. The original population sample was reinvestigated after six years in 1980-81 (n = 1138) together with an additional sample of women giving a total sample of 1422 women of ages 26, 38, 50, 58, 62, 66 and 72 years. Of the females studied in 1974-75 eight had developed hyperthyroidism between the two studies; three of these had raised serum T3 at the investigation in 1974-75. No case of hyperthyroidism had been missed by the T3 assay in the 1974-75 study. Of individuals with serum T3 greater than or equal to mean + 2.5 SD selected for a follow-up (n = 29) at least five were found to have previously unrecognized thyroid autonomy. We found a raised serum T3 to be associated with hyperthyroid (n = 2) and euthyroid Graves' disease, autonomously functioning thyroid adenoma(s), possible painless subacute thyroiditis, possible thyrotoxicosis factitia, diminished thyroid reserve and thyroid substitution therapy.

Adult↗
PubMed1984

Metabolic side effects of diuretics and beta-adrenoceptorblockers.

A review is made of the metabolic side effects of diuretics and beta-adrenoceptorblockers. The review is based on results from a population study, performed by the author, of women and on a survey of the literature. While diuretics give rise to hypokalemia, which may be of clinical importance, beta-adrenoceptorblockers tend to increase the serum potassium levels. This does not, however, seem to be of clinical significance. Both diuretics and beta-adrenoceptorblockers increase serum uric acid levels. Beta-adrenoceptorblockers increase serum triglycerides, which is not observed when diuretics are used. Total cholesterol in serum is usually not changed either by diuretics or by beta-adrenoceptorblockers. These drugs seem to have no influence on body weight when studied during long-term treatment. A further deterioration of glucose tolerance may be expected in subjects with an initially impaired glucose tolerance when diuretics are administered, while results from studies on glucose tolerance in subjects taking beta-adrenoceptorblockers have been controversial. Diabetes mellitus seems to be more common among subjects on diuretics as well as among subjects on beta-adrenoceptorblockers, but as yet it cannot be stated whether this is an effect of the antihypertensive drugs or of the hypertension per se or of some other factor or factors.

Adrenergic beta-Antagonists↗
PubMed1984

Number of teeth and proximal periodontal bone height in relation to social factors.

The dental status with respect to number of missing teeth and proximal periodontal bone height in relation to social factors were studied in a population sample of women 38-60 years of age. There was an overrepresentation of edentulous women among those who had grown up in a rural area, who had low education, and in those who belonged to a low socio-economic group (irrespective of whether the socio-economic group of the women themselves or of their husbands was studied), while no obvious differences were observed when the proximal periodontal bone height was studied in relation to social factors. The relationships between social factors and number of missing teeth seemed to be stronger than between social factors and any other variable included in the comprehensive population study, of which this examination of the dental status was one of a number of research projects.

Adult↗
PubMed1984

Morbidity and mortality in relation to blood pressure and antihypertensive treatment. A 12-year follow-up study of a population sample of Swedish women.

Morbidity and mortality in cardiovascular and cerebrovascular diseases and total mortality have been studied in a longitudinal population study initially comprising 1462 women representative of the general female population. When related to the initial blood pressure (BP) levels of women not on antihypertensive drugs (hypertensives and non-hypertensives), the distributions of women with myocardial infarction (MI) and stroke during the 12-year follow-up period seemed to be U-shaped, with the highest incidences in women with the lowest and the highest BP levels. Women recognized as untreated hypertensives in the initial study were offered regular control by the study team during the whole 12-year period and were treated when treatment was considered indicated. They were found to be similar to the non-hypertensives with regard to the incidence of MI and stroke and total mortality. Our encouraging results may be explained by continuity of medical care, the antihypertensive treatment per se or the types of antihypertensive drugs administered.

Adult↗