Biomedical subjects

C Bergiron

Publications and source records attributed to C Bergiron.

At least 19 recordsLinked to original sources

PubMed1981

[Primary mammary cytosteatonecrosis : radiological, clinical, and pathological features in 29 cases (author's transl)].

The authors report 29 cases of primary mammary cytosteatonecrosis. Diagnosis can be difficult when clinical and radiological signs suggest a cancer, and this was the case in about half of these cases. Radiological signs suggest the diagnosis in only 10 p. cent of cases, even though the evocative signs (clear images surrounded by a border of condensation) are usually associated with suspicious shin lesions, and require histological verification. Even though lesions that are limited in extent when examined clinically and radiologically may be a cancer, the inverse position, though very much less frequent, can also apply, and a very suggestive lesion with spicules and skin retraction may be benign. Histological examination before any minor surgery is always essential.

Adolescent↗

PubMed1980

[Radiographic signs of radiolesions of the pelvis (excluding the femur) after irradiation for epithelioma of the cervix uteri (author's transl)].

Radiolesions of the pelvic bones (excluding the femur) were observed in 29 patients after irradiation therapy for cervix uteri cancer. Three regions can be affected corresponding to the areas irradiated: the sacrum and internal part of the iliac wings, the pubis, and the cotyles. In most cases the lesions appeared after 1 to 4 years. Their radiological appearances are characteristic, the principal sign being irregular bone condensation in a demineralized bone, without true cavitation. The only lytic lesions observed were in the pubis. Calcification of soft tissues may occur and fractures are frequent. There is a slow progression of the lesions over long periods. Clinical, radiological, and progression signs differentiate radiolesions from other affections: metastases, invasion by contiguity, infections, and radio-induced sarcoma.

Bone Diseases↗

PubMed1979

Lymphography in childhood rhabdomyosarcomas.

Forty-one children with subdiaphragmatic rhabdomyosarcoma underwent bipedal lymphography. Twenty-two (53.5%) of the lymphograms were interpreted as being positive. In our series, the lower limbs were the most common primary site of involvement, were more frequently involved by the alveolar histologic subtype which carries a poor prognosis, and were associated with a higher incidence of lymph node metastases. Positive lymphographic findings in this group of children were similar to those seen in both adults and children with other solid tumors, i.e., the presence of discrete lymph node filling defects. However, in 3 cases, abnormalities more characteristic of lymphoma were identified. Evaluation of lymph node metastases as demonstrated by lymphography has prognostic significance.

Abdominal Neoplasms↗

PubMed1977

Experiment with 659 consecutive lymphograms in children.

Between 1963 and January 30, 1975, 659 children under 16 years of age were referred for bipedal lymphography at the Institut Gustave-Roussy. Approximately one-third were under 5 years of age. The vast majority had documented malignant disease. Successful bilateral lymphatic cannulation and lymph nodd opacification were accomplished in 86.7% of all children. Another 11.6% had successful unilateral lymphograms, which usually provided sufficient information to be considered as diagnostic stldies. In only 1.7% of all children was the study unsuccessful bilaterally. Lymphatic cannulation failure rates progressively decreased as the child increased in age. There were five "allergic" reactions (0.75%), one of which was considered life-threatening, and one instance (0.15%) of a transient neurological deficit. No permanent sequelae or deaths were attributed to the lymphogram.

Adolescent↗

PubMed1977

Lymphography in the staging, treatment planning, and surveillance of ovarian dysgerminomas.

Ovarian dysgerminomas are distinguished from other ovarian neoplasms by their rarity, their predilection for metastases via lymphatic pathways, and their radiosensitivity and favorable prognosis. After the initial surgery, which provides the histologic diagnosis and defines the local extent of pelvic involvement, lymphography is the single most useful tool to determine whether retroperitoneal lymph nodes are involved. Results of the study guide the radiotherapeutic approach, including field size and dosage. In an unselected group of 31 previously untreated patients, 10 had positive lymphograms. The response to therapy and the detection of relapse of disease may be evaluated by monitoring the residually opacified lymph nodes with surveillance abdominal radiographs. If necessary, a repeat lymphogram can be performed. The 2 year survival rate of 84% for ovarian dysgerminomas is lower than that for testicular seminomas, probably due to later recognition of the tumor. Failuresare related to local extension or to hematogenous dissemination.

Adolescent↗

PubMed1976

Repeat lymphography in children with Hodgkin's disease.

Repeat lymphography was performed in 37 children less than 16 years old with histologically proven Hodgkin's disease. The repeat studies had the same lymphatic cannulation success rates as the first lymphogram; one patient had a bilaterally unsuccessful repeat study, which left 36 for analysis. Both first and repeat lymphograms were negative in 33% of children, whereas a negative lymphogram became positive for tumor in 39%. The remaining 28% had a positive first lymphogram, with an equal incidence of positive and negative repeat studies. Reactive hyperplasia was seen in 16.7%, and post-therapeutic lymph node alteration in 22%, of all cases. Of the 22 children studied for routine opacification or because of suspected but unproved relapse, 10 (45%) had positve repeat studies. The repeat lymphogram in these patients was of utmost importance in initiating therapy. Nine of 14 patients studied for documented clinical relapse had positive repeat studies.

Adolescent↗

PubMed1975

External radiotherapy and radioiodine in the treatment of 359 thyroid cancers.

Between 1943 and 1965, 359 patients with carcinoma of the thyroid were treated by external radiotherapy or radioiodine out of a total number of 560 patients treated during the same period. In 65 of these patients surgery had been satisfactory from a macroscopic point of view. Prophylactic post-operative irradiation was given to 55 and the survival rate was 91 per cent at five years and 85 per cent at ten years. Ten received radioiodine, eight were alive at five years and six at ten years. In 95 patients excision of the tumour had been macroscopically incomplete. Fifty-four were treated by external radiotherapy and the survival rates were 50 per cent at five years and 48 per cent at ten years. For the differentiated carcinoma of this group 68 per cent were surviving at five years and 58 per cent at ten years. Of 41 patients treated with radioiodine, 75 per cent were surviving at five years and 31 per cent at ten years. Eighty-five patients were inoperable. Sixty were treated by external radiotherapy, the survival rates were 17 per cent at five years and 8.5 per cent at ten years. For the differentiated carcinomas of this group the survival rates were 24 per cent and 18 per cent. Twenty-five were treated with radioiodine, 26 per cent were surviving at five years and 4.5 per cent at ten years. The patients treated by external radiotherapy can be divided into two subgroups according to the technique of treatment and dose used. Between 1943 and 1955, patients were treated with conventional X rays (mean applied dose 2,800 rads), between 1956 and 1965 the patients were treated with 60Co (mean applied dose 5,000 rads). For the 45 patients of the first group, the survival rates were 35 per cent at five years and 32 per cent at ten years. For the 124 of the second group the respective survival rates were significantly higher: 60.6 per cent and 53 per cent. The results of external radiotherapy were similar to those of radioiodine at five years and better at ten years. In conclusion, a dose of 5,000 to 6,000 rads delivered by megavoltage external radiotherapy in five to six weeks, is well tolerated and effective mostly in differentiated carcinomas and medullary carcinomas. The survival rates of 64 patients whose metastases were unable to pick up iodine is practically zero at five years. For 68 patients with uptake in their metastases the survival rates were 53 per cent at five years and 23 per cent at ten years. The survival rate in patients with pulmonary metastases was higher than in patients with bony metastases (75 per cent versus 44 per cent at five years and 42 per cent versus 8 per cent at ten years.

Age Factors↗

PubMed1975