PubMed Health⌕ Search

Biomedical subjects

C Betourne

Publications and source records attributed to C Betourne.

17 recordsLinked to original sources
PubMed1988

[Temporal arteritis: a syndrome. From Horton's disease to periarteritis nodosa].

Four cases of histologically proven temporal arteritis presenting with atypical clinical, anatomical or evolutive features and raising nosological problems concerning the type of vasculitis involved are presented. In patients with temporal arteritis, some elements are suggestive of periarteritis nodosa. They include peripheral neurological lesions, renal or pleuro-pulmonary lesions and the histological appearance of the temporal artery. Diagnosing periarteritis nodosa in a case of temporal arteritis leads to a special therapeutic strategy.

Adrenal Cortex Hormones↗
PubMed1988

Competitive enzyme inhibition immunoassay of apolipoprotein A-I: use of monoclonal antibodies.

An original competitive enzyme inhibition immunoassay has been developed for determination of total apolipoprotein A-I (apo A-I) in serum and in plasma. This specific assay involves a single monoclonal antibody (F59 4A12 2F4, directed to the -COOH terminal region of the apo A-I molecule) and a stable secondary plasma standard. Delipidation of serum samples exposed no additional antigenic sites, which suggests that all the apo A-I molecules express the epitope detected by Mab 4A12 on the surface of the apo A-I-containing particles. Within- and between-run CVs were, respectively, 6.1% and 7.5% at a 1.47 g/L concentration of apo A-I, 7.1% and 8.2% at 1.21 g/L, and 6.5% and 7.3% at 1.80 g/L. Results (y) correlated with those obtained with an electroimmunoassay (x), in which we used a mixture of three monoclonal antibodies, including Mab 4A12, as follows: y = 250x - 7, r = 0.744, P less than 0.001.

Antibodies, Monoclonal↗
PubMed1987

[Behçet's diseases with multiple intracranial arterial aneurysms].

A case of multiple intracranial arterial aneurysms occurring in a 43 year-old patient with an 8-year history of Behcet's disease is reported. The diagnosis was based upon the past occurrence of polyarthritis, oral and scrotal aphthous ulcers and cutaneous hypersensitivity. There was a three year remission after a brief treatment with corticosteroids. At the end of this period, a left hemiplegia occurred. CT scan showed an infarction in the right middle cerebral artery territory. Angiography showed fusiform aneurysms of the intracranial right internal carotid, right anterior and middle cerebral arteries. The draining veins and sinuses were normal. Careful angiographic examination of visceral and peripheral arteries showed only bilateral retinal artery aneurysms. Large artery involvement is a rare complication of Behcet's disease, and a thorough review of the literature showed only one reported case of an intracranial aneurysm.

Adult↗
PubMed1984

[Horton's disease: a too often delayed diagnosis. Plea for an early biopsy of the temporal artery].

The diagnosis of temporal arteritis is made after a mean delay of four months. This delay is explained by the absence, in 50% of cases, of any clinical sign in the temporal area, the possible presence of alterations in liver function tests, and the frequency of anemia and loss of weight. These signs often suggest a mistaken diagnosis of hepatobiliary disease or cancer. The authors evaluate the cost of this delay in a personal series of 33 cases confirmed histologically. They recommend biopsy of the temporal artery in each patient aged more than 70 with a marked rise in erythrocyte sedimentation rate unexplained by an infectious disease or dysglobulinemia.

Aged↗
PubMed1982

[Horton's disease: retrospective study of 33 cases and review of the literature].

Temporal arteritis is still often overlooked in 1982 as shown by the diagnostic delay reported in a retrospective review of 33 patients and in the series previously published in the medical literature. Clinical features to be especially kept in mind are the occasional nature of temporal signs, the pathognomonic value of jaw claudication and the existence of signs which may constitute a premonitory syndrome of blindness. The frequent rise in alkaline phosphatase levels is often misleading. In patients over 65 with an unexplained inflammatory syndrome, biopsy of both temporal arteries should be promptly performed, prior to the unpleasant and costly investigations designed to detect an occult carcinoma. Corticosteroids are still the best treatment of giant cell arteritis but the optimal initial dosage remains unknown as no data from randomized trials are available. Symptomatic relapses have been reported up to 10 years (5 years for ocular symptoms) after onset of the disease. Because of this protracted course, which makes adequate follow-up difficult to ensure, recovery rates from different series are at variance. The main side-effects of maintenance corticosteroid therapy in these elderly patients are osteoporosis, which warrants systematic countermeasures, and probably an increased rate of atheromatosis.

Adrenal Cortex Hormones↗
PubMed1978

[Malignant non-secreting cortico-adrenalomas. Four cases (author's transl)].

In three of these four cases of malignant tumour of the adrenal cortex, a prolonged fever and a major inflammatory syndrome were the presenting features. The precise diagnosis was made before surgery only once. In two cases, it was a surgical discovery (one patient operated upon with a false diagnosis and another with no precise diagnosis). In the last case, the malignant tumour of the cortex was discovered at autopsy. The chief characteristics of these tumours are reviewed: rare ; presenting with chest pain, a mass in the hypochondrium, metastases, or general symptoms, possibly high and prolonged fever. The prognosis is gloomy, the majority of patients dying the six months which follow the operation.

Adrenal Cortex Neoplasms↗
PubMed1977

[Malignant lymphopathy in a patient suffering from acute disseminated lupus erythematosus (author's transl)].

The authors report a case of acute disseminated lupus erythematosus in a 55 years old patient, receiving small doses of corticosteroids, progressing over three years. During an acute exacerbation of the disease, the development of a cervical adenopathy led to a biopsy. Histological examination revealed a lymphocytic type malignant proliferation (centro-follicular lymphoma). This case is compared with findings reported in the literature and leads to a discussion of the relationship between ADLE and malignant disorders due to a disturbance of immune control mechanisms and the possible role of immune-depressant therapy in their onset.

Chlorambucil↗
PubMed1977

[Development and long term prognosis of lupus erythematosus (apropos of 124 cases)].

The authors report their experience of the course of lupus erythematosus. The ten year survival rate in 124 patients was 79.3 %. This good result is attributed to the effective treatment of the disorder using corticosteroids; often associated with ummuno-suppressants in severe cases. However, the side-effects of these drugs remain a source of concern and the ideal treatment for lupus has yet to be discovered.

Adrenal Cortex Hormones↗