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C Bewtra

Publications and source records attributed to C Bewtra.

36 records · Page 2Linked to original sources
PubMed1987

Malignant fibrous histiocytoma of the heart. A case report and review of the literature.

A case report of a 28-year-old woman with malignant fibrous histiocytoma (MFH) of the left atrium is presented, and the six previous reports of this rare cardiac tumor are reviewed. A tendency for malignant fibrous histiocytoma of the heart to occur in the left atrium of young women is suggested; this sarcoma's usual location is in the soft tissue of elderly men. The apparent predilection for the left atrium is unique among cardiac malignancies. Careful pathologic study is necessary to differentiate the uniformly fatal MFH of the heart from the more common benign atrial myxoma.

Adult↗
PubMed1987

Cystic adventitial degeneration of the femoral artery: is evacuation and cyst excision worthwhile as a definitive therapy?

A case of cystic adventitial degeneration of the left common femoral artery in a patient with localized left groin pain, normal distal pulses, and normal arteriographic findings is reported. This patient was first treated with evacuation and cyst excision. Recurrence was noted after 20 months, and an excision of the cyst and a segment of the common femoral artery with graft interposition was required. At gross examination, the cyst was unilocular and contained gelatinous material. The cyst appeared to be situated in the tunica adventitia and did not communicate with the vascular lumen. No synovial lining was present. Histologically, it was similar to a ganglion cyst with contents rich in hyaluronic acid. A review of the literature was undertaken to determine the results of treating this lesion. The disease is rare. All senior authors of case reports were contacted to construct follow-up information. A high incidence of recurrence was noted in patients treated by evacuation and cyst excision. We believe that total cyst excision with the involved artery and graft interposition at the femoral site can be done easily, safely, and with virtually no chance for recurrence.

Arterial Occlusive Diseases↗
PubMed1986

Familial ovarian carcinoma. Clinical nuances.

Familial ovarian carcinoma has been recognized with increased frequency during the past decade commensurate with physician attention to family history. Putative autosomal dominant inheritance of this heterogeneous problem mandates attention to both paternal and maternal lineages. A family with probable paternal transmission of breast/ovarian carcinoma is presented. One family member had findings consonant with papillary serous adenocarcinoma of ovarian origin, which may have arisen directly from extra-ovarian pelvic mesothelium. These and other clinical nuances of familial ovarian carcinoma are discussed in order to aid physicians in understanding the natural history, surveillance, and management of familial ovarian carcinoma.

Adult↗
PubMed1986

Familial peritoneal ovarian carcinomatosis: a new clinical entity?

A familial form of ovarian carcinoma is now widely recognized. There are at least several ovarian cancer-prone genotypes, consistent with genetic heterogeneity. Prophylactic oophorectomy has been employed for women who were judged to be at 50% risk for this disease by virtue of their position in the pedigree. However, recent evidence has disclosed that a fraction of such patients who underwent prophylactic oophorectomy and who had ovaries which appeared to be histologically normal at surgical resection, subsequently developed intraabdominal carcinomatosis with histologic findings showing the lesions to be indistinguishable from ovarian carcinoma. Given the embryologic derivatives of the ovary, which comprise gonadal ridges composed of mesodermal cells covered by coelomic epithelium, we postulate that patients with hereditary predisposition to ovarian carcinoma harbor the first germinal hit in both the epithelial cells of the ovary as well as their derivatives in the coelomic mesothelium. These patients may then be inordinately susceptible to carcinogenesis from the second (somatic) hit in these same tissues.

Adenocarcinoma, Papillary↗
PubMed1985

Constrictive calcific pericarditis following coronary arterial bypass surgery.

A case of postsurgical constrictive calcific pericarditis is reported. The unusual features of this case are the short interval (two months) from surgery to the development of pericarditis and the involvement of the coronary arterial grafts, resulting in tearing of the vessels and the death of the patient during decortication.

Aged↗
PubMed1984

Multiple primary bronchogenic carcinomas, with a review of the literature.

Four cases of dual, primary lung carcinomas are presented. Three are metachronous, one case is synchronous. The average time between the metachronous tumors is 20 months. All the cases have different histological types, with combination of squamous cell carcinoma and adenocarcinomas being the most common. All the patients were male, above 60 years of age and were heavy smokers. A review of the literature is made and diagnostic criteria, epidemiological factors, and prognosis are discussed.

Adenocarcinoma↗
PubMed1984

Tubuloreticular inclusions in systemic lupus pneumonitis. Report of a case and review of the literature.

Tubuloreticular inclusions have been described with sufficient frequency in certain tissues of patients with systemic lupus erythematosus (SLE) to make the finding of such inclusions helpful in making a diagnosis of this disorder. The finding of such inclusions in lung biopsy specimens, however, has been distinctly rare. We report herein the ultrastructural findings in the case of a young woman with active systemic LE showing tubuloreticular inclusions within lung and kidney biopsy specimens.

Adult↗
PubMed1982

Intrapericardial giant lymph node hyperplasia.

This report concerns a female patient aged 42 years known to have asymptomatic cardiomegaly for 2 years. She presented 2 weeks before surgery with chest pain radiating to the left arm and face. Angiography revealed a highly vascular mass in the region of the left atrium. Surgery revealed an intrapericardial tumor adherent to both atria. Histologically this proved to be giant lymph node hyperplasia, an unusual example because of its intrapericardial localization.

Adult↗
PubMedDate not supplied

Genital human papillomavirus testing by in situ hybridization in liquid atypical cytologic materials and follow-up biopsies.

OBJECTIVE: To describe cases of HPV testing by DNA in situ hybridization performed on atypical cervicovaginal samples collected by a liquidsed method that were negative for HPV DNA on cytology but revealed cervical intraepithelial neoplasia on follow-up biopsies. STUDY DESIGN: Three hundred ninety-five consecutive SurePath atypical squamous cells of undetermined significance (ASC-US) cytologic samples from asymptomatic, reproductive-age women were tested for human papillomaviruses (HPVs) by the in situ hybridization (ISH) method (Ventana Inform HPV Test, Tucson, Arizona, U.S.A). One hundred (25%) cases underwent follow-up colposcopic biopsy within 3 months of cytology. All the tests (cytology, ISH, histology) were independently evaluated without knowledge of the other tests. RESULTS: One hundred twenty-two (33%) cytologic samples were positive for HPVs. Of a total of 100 (HPV positive and negative) follow-up biopsies, 55 were positive for cervical intraepithelial neoplasia (CIN). Fourteen cases of biopsy-proven CIN tested negative for all HPV types in the prior cytologic samples. Retesting of the 14 CIN tissues by ISH was negative in 10, positive for HPV in 2 and inconclusive in 2. CONCLUSION: There is a small but significant (14%) false negative rate with HPV testing by the Ventana ISH method. Clinically suspicious cases should be followed even if an HPV test is negative.

Adolescent↗
PubMedDate not supplied

Cytology of peritoneal fluid from patients on continuous ambulatory peritoneal dialysis.

Peritoneal fluids from 41 patients on continuous ambulatory peritoneal dialysis (CAPD) were examined. The patients were divided into a short-term group (18 patients with CAPD up to one year) and a long-term group (23 patients with CAPD for one to seven years). Peritoneal fluids from a control group, consisting of ten nondialysis patients with ascites, were also examined. The cellular background of the peritoneal fluids and, in particular, the morphology of the mesothelial cells were studied. The following were found to be significantly increased in the CAPD groups: background lymphocytes, mesothelial exfoliation in three-dimensional clusters, mesothelial nuclear size and the number of mesothelial nucleoli. All of these features increased slightly with an increased duration of the dialysis. These findings emphasize that peritoneal dialysis of any duration can induce significantly atypical changes in mesothelial cells.

Ascites↗
PubMedDate not supplied

Ultrastructural studies of cells in body cavity effusions.

Transmission electron microscopic examination of benign (16 cases) and malignant (2 cases) mesothelial cells and metastatic carcinoma (10 cases) was performed. These studies showed long, slender, branching and bushy microvilli with high length-to-diameter ratios to be the most important distinguishing features of the mesothelial cells. Cytoplasmic intermediate filaments were present in all mesothelial cells as well as in carcinoma cells. The mesothelial cells showed an absence of mucin vacuoles, intracellular lumens and luminal tight junctions, which are seen in adenocarcinoma cells. The pinocytotic vesicles were found to be more numerous in the mesothelial cells. Lipid vacuoles, lysosomes, Golgi apparatus and intercellular lumens appeared to be variably present in all mesothelial and carcinoma cells. The methodology is discussed and pertinent literature reviewed.

Adenocarcinoma↗
PubMedDate not supplied

Exfoliative sputum cytology in pulmonary embolism.

In a prospective, double-blind, randomized study of cytologic changes found in pulmonary infarction, nine roentgenologically proven cases of pulmonary embolism were studied with sputum samples from the 1st to 26th postinfarction days. Maximum atypical cytologic changes were seen during the second and third postinfarction weeks. Specific cytologic features included three-dimensional clusters of glandular cells with enlarged nuclei and macronucleoli: they were malignant-appearing cells except for their inconsistent morphology, fewer numbers, transient appearance and lack of solitary atypical cells. A similar study in a canine model is discussed, and a case of pulmonary embolism with abnormal cytology and corresponding histology is presented.

Adult↗