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C Beylot

Publications and source records attributed to C Beylot.

At least 19 recordsLinked to original sources
PubMed1992

Efficacy and safety of calcipotriol (MC 903) ointment in psoriasis vulgaris. A randomized, double-blind, right/left comparative, vehicle-controlled study.

BACKGROUND: The biologically active form of vitamin D3, calcitriol, may offer a new therapeutic approach to psoriasis. Calcipotriol, a new vitamin D3 analogue, is at least 100 times less calcemic than calcitriol. OBJECTIVE: Our purpose was to study the efficacy and safety of calcipotriol in the treatment of psoriasis vulgaris. METHODS: In a right/left comparative, double-blind study, treatment with calcipotriol ointment (50 micrograms/gm) twice daily and placebo was given for 4 weeks. The preferred treatment was continued, without opening the code, for another 4 weeks. Efficacy, as measured by the Psoriasis Area and Severity Index and by the investigator's and patient's global assessment, and safety were assessed every 2 weeks. RESULTS: The mean Psoriasis Area and Severity Index fell in 4 weeks from 14.2 to 6.3 with calcipotriol and from 14.1 to 9.2 with placebo (p < 0.001; 95% confidence interval for difference: 1.78-->3.94). Local side effects were equally common with calcipotriol and placebo. The mean serum calcium remained unchanged. CONCLUSION: Topical application of up to 50 gm of calcipotriol ointment per week was found to be an effective and safe treatment of psoriasis vulgaris.

Adult↗
PubMed1992

Chilblain lupus erythematosus: report of 15 cases.

In this retrospective study, the authors describe the clinical, histologic and laboratory features of 15 cases of chilblain or perniotic lupus. In winter, the patients (14 women, 1 man) develop chilblain-like lesions, chiefly in the toes (8 times) and fingers (11 times). Histologic features are identical to those of discoid lupus erythematosus. The damaged skin gives a positive fluorescent band test. Usually, these lesions occur in association with discoid lupus of the face. However, in 8 patients, they were the only cutaneous sign of lupus. This form of lupus can evolve to a systemic form, as was the case with 3 patients.

Adult↗
PubMed1992

[Cutaneous vasculitis].

Explore the source record for details and available documents.

Acquired Immunodeficiency Syndrome↗
PubMed1991

[Specific aspects of psoriasis in children].

In 15% of the cases psoriasis begins before the age of 10 years, but it is often overlooked since its typical and obviously diagnostic nummular lesions are not the most frequently found. Some clinical features are very specific of children, such as eruptive guttate psoriasis occurring soon after an upper airway infection, and, mainly, the pauci-symptomatic forms which are difficult to diagnose as they are often very mild and for a long time reduced to one single lesion. The so-called "napkin psoriasis" is the usual early expression of the disease in infants. The severe, pustular, often annular, erythrodermal congenital and arthropathic forms of psoriasis are rare in children. Treatment must be prescribed with particular caution it that age, but in the severe and/or expansive types retinoids and very short courses of PUVA therapy are required.

Age Factors↗
PubMed1991

Eosinophilia associated with a composite lymphoma.

We report a case of composite lymphoma heralded by a hyper-eosinophilia syndrome. Combination of immunophenotyping and gene rearrangement analysis allowed us to confirm malignancy and to detect a minor oligoclone B within a malignant T-cell predominant population. No evidence of retroviral infection was found using western blot and gene amplification techniques.

Adult↗
PubMed1991

Porphyria cutanea tarda associated with human immunodeficiency virus infection. A study of four cases and review of the literature.

We report the cases of 4 male subjects, 29, 32, 41 and 44 years old, presenting isolated seropositivities for the human immunodeficiency virus (HIV), or full-blown acquired immunodeficiency syndrome, associated with a typical porphyria cutanea tarda (PCT). The 4 patients are in the usual risk groups for HIV infection. Viral hepatitis was observed in 3 of the 4 cases. Over the past 3 years, 15 cases associating HIV infection and PCT have been reported; almost all had the usual risk factors for HIV infection and hepatopathy. We speculate that HIV infection may have favored the occurrence of early PCT in these cases by altering the metabolism of the porphyrins, either directly or by means of the associated hepatopathy.

Adult↗
PubMed1991

[Clinical signs of cutaneous aging].

Skin ageing depends on several, closely connected causes, including ageing obviously, but also on environmental factors, such as smoking and also, in women, on estrogen deficiency due to the menopause, but above all exposure to sunlight, particularly in fair-skinned individuals. The changes due to time-related ageing, thinner, withered skin are similar to those caused by the menopause, which also induces some signs of hyperandrogeny. Sun-related changes, which occur mainly on uncovered areas, vary so widely that some authorities prefer the terms "dermato-heliosis" or "helio-dermatitis" to that of solar ageing. Solar elastosis is the most typical change and is visible on the face as a yellowish skin criss-crossed by deep wrinkles. On the neck and extended surfaces of the limbs, the skin is atrophied and often dyschromic. Excessive exposure to the sun is also responsible for most skin cancers, which are known to occur mainly on exposed parts.

Aged↗
PubMed1990

[Chronic lupus erythematosus, subacute cutaneous lupus].

The cutaneous manifestations of lupus erythematosus (LE) are extremely varied, and they predominate among the clinical signs of chronic LE and subacute cutaneous LE. In chronic LE, typical lesions are found in regions exposed to sunlight and consist of erythema, hyperkeratosis and skin atrophy. The skin of patients with subacute cutaneous LE is also highly sensitive to light; the lesions consist of an annular or polycyclic or sometimes psoriasiform erythemato-squamous eruption observed mainly in uncovered areas. These dermatological forms are part of the wide spectrum of "lupus". Cutaneous manifestations are often associated with systemic signs of varying type and severity and with immunological abnormalities, such as antibodies to Ro in subacute cutaneous LE, which act as markers of the disease.

Adult↗
PubMed1990

Treatment of leg ulcers with an allogeneic cultured-keratinocyte-collagen dressing.

A living cellular allogeneic dressing made up of cultured keratinocytes adhering to a collagen film was used to treat 20 leg ulcers of various aetiologies in 16 patients. A reduction in pain was noted in 80% of cases, and promotion of granulation tissue in the ulcer bed in 70% of cases. In 10 patients, epithelialization of 71 +/- 29% of the ulcer was noted at Day 30.

Aged↗