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Biomedical subjects

C Bonnet

Publications and source records attributed to C Bonnet.

At least 19 recordsLinked to original sources

Adolescent osteoporosis disclosing familial osteopenia.

The observations of familial juvenile osteoporosis, presumably of genetic origin are exceptional. The authors report the observation of a 16-year old adolescent suffering from osteoporosis, confirmed by histomorphometry and decrease in bone density (lumbar vertebrae 0.79 g/cm2 and femoral neck 0.88 g/cm2: LUNAR DPX). We prescribed fluorine and calcium therapy. Lumbar bone density increases by 11% and bone density of the thighbone neck by 7.6%. We cannot rule out growth as a factor in the changes observed, given that the propositus is only 16. A densitometric investigation performed in 4 of his 12 brothers shows a decrease in the lumbar bone mineral content (from 61 to 94% expressed as Z score). A genotypic origin seems to be conceivable, especially since no other cause could be considered (endocrinal, alimentary...). On the other hand, there is no argument in favour of osteogenesis imperfecta disease. The bone densitometry is a useful diagnostic means to detect familial forms of osteoporosis.

Adolescent

[Nicardipine vs trinitrin for controlled hypotension in maxillo-facial surgery].

In this study we examined perioperative blood losses during maxillo-facial surgery comparing 2 techniques for controlled hypotension using nitroglycerin (NTG) and nicardipine (NICAR). 37 ASA I and II patients electively scheduled for rhinoseptoplasties under general anaesthesia were randomly divided into 2 groups. General anaesthesia was induced with intravenous thiopental and vecuronium following a neuroleptanalgesia consisting of fentanyl (0.053 +/- 0.004 microgram.kg-1.min-1) IV and droperidol (1.98 +/- 0.35 microgram.kg-1.min-1) IV given in bolus doses. The patients were intubated and ventilated (N2O in O2) to maintain normocarbia. Controlled hypotension to maintain a mean arterial pressure (MAP) between 50 and 55 mmHg was induced using an IV infusion of NTG 6 micrograms.kg-1.min-1 in group I and NICAR 10 micrograms.kg-1.min-1 over 10 minutes followed by an infusion at 4 mg.kg-1.min-1 for group II. Measurements of heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), MAP using an automated blood-pressure cuff and end tidal carbon dioxide (ETCO2) were recorded prior to induction (PREIND), intraoperatively (PEROP) at 15, 30, 40 and 120 minutes post-induction, and at 15, 30 and 60 minutes postoperatively (POSTOP). Blood loss, graded as minimal or frank, was assessed by the surgeon during the operative period, post-extubation and 3 days postoperatively at dressing removal. The surgeon was unaware of the randomization schedule. Student's test was applied for statistical analysis of measured variables and Fisher's test for qualitative parameters. No statistically significant differences were noted between both groups with respect to demographic data, duration of surgery and total doses of anaesthetic agents (Table I).(ABSTRACT TRUNCATED AT 250 WORDS)

Adult

Psychophysical evidence for low-level processing of illusory contours and surfaces in the Kanizsa square.

Increment thresholds were measured on either side of one of the illusory contours of a white-on-black Kanizsa square and on the illusory contour itself. The data show that thresholds are elevated when measured on either side of the illusory border. These elevations diminish with increasing distance of the target spot from the white elements which induce the illusory figure. The most striking result, however, is that threshold elevations are considerably lower or even absent when the target is located on the illusory contour itself. At an equivalent position in a control figure where no illusory contour is visible, such a threshold decrease does not occur. The present observations add empirical support to low-level explanations of illusory contour perception.

Female

A study of the effect of structural information and familiarity in form perception.

Two experiments were carried out to investigate the influence of structural information and familiarity on the processing of visual forms. Pairs of "well" structured and nameable and "poorly" structured and non-nameable fragmented forms were employed as stimuli. The effects of structure and familiarity were assessed by manipulating the visual hemifield of presentation and the task. In Experiment 1 stimuli were judged as being either in the same orientation or mirror-reversed, a task that does not require high-level semantic information to be processed. Experiment 2 required physically identical forms to be matched, which may use either physical or name information. In Experiment 1 "same" judgements were equivalent for both types of stimuli, and "different" judgements were longer for the "poorly" structured (non-nameable) forms. In Experiment 2 there was little overall difference between "well" and "poorly" structured forms, though response times to "well" structured (nameable) forms were slowed for right-visual-field presentations. It is suggested that familiarity may not be sufficient to provide a perceptual advantage for nameable forms, as the advantage for nameable stimuli was confined to "same" judgements in Experiment 1 and response times were shorter for non-nameable stimuli in Experiment 2. Rather, performance depends upon factors such as the computation of global shape (due to structural properties of collinearity and closure) and on the use of different kinds or representations (physical versus name) in matching.

Adult

Changes in left ventricular ejection fraction during REM sleep and exercise in chronic obstructive pulmonary disease and sleep apnoea syndrome.

Nine patients, 4 with chronic obstructive pulmonary disease (COPD) and 5 with obstructive sleep apnoea syndrome (OSAS) were monitored during sleep, rest and exercise. Left ventricular ejection fraction (LVEF) was investigated using gated equilibrium 99mtechnetium ventricular scintigraphy during rapid eye movement (REM) sleep, during exercise, and during wakeful rest. Control wakeful rest periods used for comparison with a study state (either REM sleep or exercise) were always selected during the same circadian segment as that state. Myocardial stress thallium-201 scintigraphy was performed during, and 4 h after, exercise, and results were compared to a daytime rest period. Several patients had myocardial hypoperfusion despite a normal electrocardiographic (ECG) treadmill test. During REM sleep, all patients exhibited a significant change in LVEF (greater than 5%) compared to wakefulness. During exercise, 5 subjects increased their LVEF normally (greater than 5%) and 4 (1 COPD, 3 OSAS) decreased it. All patients had a similar change (increase or decrease) during REM and at maximal exercise. Our results suggest that REM sleep in COPD and in OSAS can produce a myocardial stress as great as that produced by exercise. We conclude that REM sleep, like exercise, is a state in which morbidity may become higher and that it may account for mortality in COPD and OSAS patients with compromised myocardial circulation.

Adult

Apparent brightness enhancement in the Kanizsa square with and without illusory contour formation.

The perceived strength of darkness enhancement in the centre of surfaces surrounded or not surrounded by illusory contours was investigated as a function of proximity of the constituent elements of the display and their angular size. Magnitude estimation was used to measure the perception of the darkness phenomenon in white-on-grey stimuli. Darkness enhancement was perceived in both types of the stimuli used, but more strongly in the presence of illusory contours. In both cases, perceived darkness enhancement increased with increasing proximity of the constituent parts of the display and with their angular size. These results suggest that the occurrence of darkness (or brightness) enhancement phenomena in the centre of the displays is not directly related to illusory contour formation.

Adult

[The image of intravertebral somatic gaseous dissection. Report of 9 cases one of which has a triple localization and review of the literature].

We report a series of 9 cases of vertebral somatic gaseous dissection studied between 1978 and 1989. We find most of the characteristics established from the literature data: advanced age, possible medullar compression contrary to the vertebral compression by common osteoporosis, predilection for the dorso-lumbar junction, frequency of the osteoporosis, possibility of metabolic disorders, of occurrence after radiotherapy. The context of the occurrence and the paraclinical examinations of the whole have enabled us to eliminate, in this series, a malignant pathology. However, when there exists a doubt on a malignant origin, it is preferable to carry out a vertebral biopsy with a trocar. In fact, the image may not be pathognomonic of a benign vertebral osteoporosis. Finally, we give the first description of a triple localization of vertebral gaseous dissection.

Aged