Biomedical subjects
C Bonnet
Publications and source records attributed to C Bonnet.
[Preventive therapy for nausea and vomiting in patients on opioid therapy for non-malignant pain in rheumatology].
OBJECTIVE: To determine if systematic use of metoclopramide associated with opioids (Morphine sulfate SR) decreases the incidence of nausea and vomiting (N&V), established adverse effects of opioids. METHOD: Open randomised study with 132 patients treated for non malignant pain (71 women, 61 men, mean age 53.4 years). One group (n = 76) was treated with morphine alone; the other (n = 56) with morphine plus metoclopramide. Mean duration of therapy: 6 days; mean dosage: 60 mg/d RESULTS: In the 2 groups, N&V were present in the first 72 hours. The frequency of N&V in the morphine group was 38.1% (conform with the literature). The systematic use of metoclopramide decreases the frequency of N&V: p < 0.005. However the use of morphine > 60 mg/d decreases N&V: p = 0.036. High dosages of morphine can have an antiemetic effect by interaction with the mu receptors in the antiemetic center and not in the trigger zone which has an emetic effect. CONCLUSION: The systematic use of metoclopramide with opioid therapy for non malignant pain in rheumatology decreases the risk of nausea and vomiting.
[Improvement in performances of an apparatus testing membrane resorption in vitro, by automatic adjustment and regulation of pH].
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[Urban and rural psycho-geriatric experience].
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[Permanent education of psychiatric nurses].
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[Basic education of psychiatric nurses. Current problems].
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[The fidelity of an apparatus for the testing of the absorption of drugs "in vitro". Some absorption profiles].
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[Reflexions on the influence of the traditional family environment on the structuration of the personality in Morocco].
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Weight loss: an unusual side effect of methotrexate.
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[Cognitive processes in perception: perceptive knowledge].
In an information processing approach, this paper attempt to show how different levels of processing visual information can be organized Sensory processing makes local coding of some dimensions. Then comme a step of structuration consisting in "putting together" these locally coded dimensions. These informations have finally to be interpreted on the basis of cognitive representations. Several examples are presented illustrating how ambiguities can appear between sensory information and various cognitive interpretations.
[The psycho-affective dimension].
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[Non-steroidal anti-inflammatory agents and cyclooxygenases].
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[Methotrexate and non-steroidal anti-inflammatory agent combination in rheumatoid arthritis].
It is well known that methotrexate (MTX), used at high dosage in cancer patients, must not be combined with a non-steroidal anti-inflammatory drug (NSAID) because of high risk of side effects; prescribed at low dosage (< or = 15 mg per week) in rheumatoid arthritis patients, MTX is often combined with an NSAID. Some cases reported in the literature underline the potential toxicity of the association of low dose MTX with an NSAID, but most of the pharmacological studies do not confirm this hypothesis. Except for salicylates, NSAIDs do not affect the absorption, distribution, protein binding, area under the curve, half-life, or the elimination of MTX. Therefore, if necessary, MTX (< or = 15 mg per week) can be combined with an NSAID during the treatment of rheumatoid arthritis.