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C Boudet

Publications and source records attributed to C Boudet.

At least 37 records · Page 2Linked to original sources
PubMed1986

Comparative effect of tropolone and diosmin on venous COMT and sympathetic activity in rat.

The ability of diosmin to inhibit venous catechol-O-methyltransferase (COMT) activity was studied comparing it with tropolone in rat superior mesenteric vein (MV), inferior vena cava (IVC) and saphenous vein (SV). Diosmin inhibited COMT activity in the mesenteric vein after 200 and 400 mg/kg i.p., but only at 400 mg/kg in IVC. The COMT inhibitory effect of diosmin (400 mg/kg) was smaller than that of tropolone (50 mg/kg). Furthermore, diosmin, but not tropolone, increased urinary normetanephrine (NMN) excretion (+56%) at 400 mg/kg and that of 3-methoxy 4-hydroxyphenylglycol (MHPG) in a dose-dependent way, thus suggesting that diosmin may exert an activating effect on sympathetic activity. Both mechanism--local inhibition of COMT and enhanced sympathetic activity--may contribute to increase NE levels in the synaptic clefts of the vascular wall and explain the venoconstrictor effect of this drug.

Animals↗
PubMed1985

[Acute necrotizing retinitis. Apropos of 2 cases].

Two cases of acute retinal necrosis are reported, the etiology of this affection being priorly defined. The lesions were bilateral in the first case, and retinal detachment developed: the first eye was inoperable, and surgery was unsuccessful for the second eye in spite of a salvage vitrectomy after a classical operation. We therefore treated the second case with immediate and massive corticotherapy, and, mainly, preventive total vitrectomy as soon as the first signs of vitreous retraction appeared and before the occurrence of retinal detachment. This preventive vitrectomy, not previously described to our knowledge, seems to provide favorable results.

Acute Disease↗
PubMed1984

Studies on the central or peripheral origin of free and sulfated 3,4-dihydroxyphenylacetic acid in rat plasma.

The concentrations of free and sulfated 3,4-dihydroxyphenylacetic acid (DOPAC) were measured in rat plasma to investigate their potential central or peripheral origin. Stimulation of central dopamine (DA) metabolism by a long-acting neuroleptic, pipotiazine (PPZ) selectively increased plasma levels of DOPAC sulfate whereas peripheral inhibition of monoamine oxidase by debrisoquin sulfate decreased free DOPAC levels only. These data suggest that the two forms of plasma DOPAC (free and sulfate) may have independent topographic origins. Peripheral DA pools seem to be the most likely sources for plasma free DOPAC whereas central dopaminergic neurons mainly contribute to plasma sulfated DOPAC. Our findings thus demonstrate that plasma DOPAC sulfate may be a useful indicator for central DA function in rat. Although further experiments are necessary to extrapolate our findings from rat to man, arguments are given indicating that measurements of plasma DOPAC sulfate might be of interest in human pathological and pharmacological investigations.

3,4-Dihydroxyphenylacetic Acid↗