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Biomedical subjects

C Boulat

Publications and source records attributed to C Boulat.

4 recordsLinked to original sources
PubMed2005

[Evolution of indications and consumptions of fresh frozen plasma from 1997 to 2003 in a teaching Hospital].

OBJECTIVE: Study the evolution for 7 years of the distribution of fresh frozen plasma consumptions (FFP) according to the therapeutic indications. MATERIALS AND METHODS: Introduction in the software of the blood bank of a specific character during the distribution of all the homologous FFP allowing a selective sort of the consumptions of FFP according to their therapeutic indications. These "qualifying terms" are defined in function, not only of the French legal references (issued on 3 December 1991),--consumption coagulopathy--global or specific deficit in coagulation factor, but also according to the specificities of our health care institution (liver transplant--thrombotic microangiopathies--open heart surgery). RESULTS: During 7 years, the consumption of FFP trebled in our institution. The indications of the FFP are now mainly medical, its use in surgery dramatically decreased. The complications are not very frequent, most of them are slight allergic reactions. CONCLUSION: New therapies, molecules coming from the research, recombinant proteins or coming from the plasma fractionation will certainly modify the indications of the fresh plasma frozen in the coming years. The supervision of our practices remains essential.

Blood Banks↗
PubMed2004

[Current data on granulocytes donations].

Granulocyte transfusion is uncommon but essential for some aplastic patients with major infection and those with septic granulomatosis disease and visceral aspergillosis. Compatibility between donor and recipient (ABO, D, Kell blood type, cytomegalovirus) is necessary. Stimulation by dexamethasone, before use of GCSF, permits to obtain approximately 10 x 10(9) white cells per l. Doses of heparin must be calculated to ensure an efficient hypocoagulation without any trouble for the donor immediately after his donation. Sedimentation by hydroxyethylstarch is an unavoidable element to obtain the most efficient separation of granulocytes. Most donations present an amount of white cells between 2 and 4 10 x 10(10). This enables to transfuse efficiently children and adults.

Adult↗
PubMed1991

[Programmed autologous transfusion in coronary surgery: experience with 106 patients].

Patients undergoing elective coronary bypass surgery can benefit from Preoperative Autologous Blood Donation (PAB), despite some opinions to the contrary, as a complement of intra-operative blood salvage techniques. We report herein 106 patients eligible for coronary bypass surgery included in our PAB program. We observed a very good tolerance owing to strict exclusion criteria, a close monitoring of vital signs, and as far as we are concerned, to the infusion of a macromolecular solution (Plasmion) in a 1:1 ratio, to maintain intra-vascular volume. We chose a volume replacement because the physiological adaptation to hypovolemia is altered by the beta-blocking and/or vasodilating agents which cannot be discontinued in patients with coronary heart disease. The changes in the hematological parameters are not different from those observed in other patients eligible for PAB. The postoperative hemoglobin level is satisfactory and compatible with a normal myocardial function inasmuch as the cardiopathy has been corrected. The efficiency of PAB is good since overall, 74% of the patients did not require homologous blood, this proportion rises to 84% for patients donating 3 or more units. Preoperative Autologous Blood Donation for patients with coronary heart disease implies a perfect coordination between the Blood Bank physicians and their colleagues from the Cardiology Department. Aside from its well known advantages, PAB allows a stimulation of erythropoiesis, a progressive normovolemic hemodilution perhaps beneficial to patients with coronary heart disease, and finally, a better psychological preparation to surgery.

Blood Transfusion, Autologous↗