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Biomedical subjects

C Bregeon

Publications and source records attributed to C Bregeon.

40 records · Page 3Linked to original sources
PubMedDate not supplied

[Evolution of patients with rheumatoid arthritis treated with immunosuppressive agents between 1965 and 1973].

The authors report the results of a study of 139 of their patients with severe rheumatoid arthritis, treated with chlorambucil of cyclophosphamide between 1965 and December 1973, with an observation period of 4 to 12 years. 8 patients were lost to follow-up, 38 died and 93 were reexamined. In this series 7 deaths were attributed to hemolymphoreticulopathy of various cytological types; 6 deaths were due to visceral cancer and 2 others to cancer of the tonsils. They confirm that such treatments increase the risk of hemopathy but apparently not the risk of visceral cancer. The risk was not a function of the total dose of the drug administered since no neoplasia was observed in the 25 subjects who received the highest doses. The addition of chlorambucil to cyclophosphamide seems to increase the risk of hemopathy. It was noticed that the 7 cases of hemolymphoreticulopathy occured after 60 years.

Adult↗
PubMedDate not supplied

Comparison of 90 degrees and 30 degrees laterally inclined positions in the prevention of pressure ulcers using transcutaneous oxygen and carbon dioxide pressures.

Although proper positioning is an important measure in pressure ulcer prevention, few objective measurements have been reported of the effects of different positions on oxygen supply to the skin area in direct contact with the mattress. This study compared the effects of 30 degree and 90 degree laterally inclined positions on the cutaneous oxygen supply to the skin through the measurement of transcutaneous oxygen pressure (TCPO2) and transcutaneous carbon dioxide pressure (TCPCO2) on the trochanteric (T) and the retro-trochanteric (R) areas in 20 healthy volunteers. Resting values were TCPO2 (T) 69.4 mm Hg (SD = 10.4), TCPCO2 (T) 36.3 mm Hg (SD = 5.1), and TCPO2 (R) 69.9 mm Hg (SD = 9.2). In the 90 degree laterally inclined position, the TCPO2 (R) value (68.2 mm Hg [SD = 9.9]) did not differ significantly from the resting value. These results show a dramatic impairment of oxygen supply to the skin in the 90 degree laterally inclined position but not in the 30 degree laterally inclined position. Additional studies of patients immobilized for long periods are needed to confirm the best positioning to prevent pressure ulcers.

Blood Gas Monitoring, Transcutaneous↗