Biomedical subjects

C Brisson

Publications and source records attributed to C Brisson.

58 records · Page 4Linked to original sources

PubMedDate not supplied

[Clinical use of the assay of the thyroxin-binding-globulin (TBG) and of the calculated index: T4/TBG (author's transl)].

The level of TBG in normal adults is 2.21 +/- 0.4 mg/100 ml, without any sex difference. TBG levels are high in the neonatal period (3.26 +/- 0.49 mg/100 ml) and in children under the age of 1 year (2.61 +/- 0.66 mg). Estrogens induce a significant increase (3.96 +/- 1.0 mg) and corticoids a significant decrease of TBG (1.44 +/- 0.32 mg). TBG is also decreased in thyrotoxicosis (1.88 +/- 0.34 mg) but normal in hypothyroidism. There is a strong correlation between T4 and TBG levels, and the T4/TBG ratio appears to be a useful index, which remains constant in normal adults, and under treatment by estrogens and corticoids.

Adrenal Cortex Hormones↗

PubMedDate not supplied

[Impact of occupational stress on health status in Canada].

Studies have shown that high psychological demands and low decision latitude may be involved in the development of major health problems. The objective of the current study was to describe the importance of these factors among the Canadian working population. The sample included 7,250 participants from the National Population Health Survey (NPHS) of 1994-95. Women were significantly more exposed than men to high psychological demands (56% versus 49%), to low decision latitude (61% versus 49%), and to these two factors simultaneously (33% versus 22%). The exposure to each of these factors was more frequent among younger and less educated people. Simultaneous exposure to both factors was more frequent among younger people and those with intermediate education level. There was a socio-economic gradient for the exposition to these factors. Some jobs with the highest exposure were identified.

Adolescent↗

PubMedDate not supplied

[Validity of occupational stress and decision latitude on health in the National Population Health Survey of 1994-95].

Psychosocial environment at work is now considered a health determinant. The National Population Health Survey (NPHS) of 1994-95 is the first study in which psychological demands and decision latitude at work were measured in a random sample of the Canadian population. However, psychometric properties of the scales used in NPHS to measure these factors are not known. The objective of the present paper was to evaluate some validity parameters of the scales used in the NPHS by comparison to the original scales recommended by Karasek to measure these factors. Results of the current study support the validity of the decision latitude scale. However, validity of the psychological demand scale is more limited.

Adolescent↗

PubMedDate not supplied

[Gray platelet syndrome].

BACKGROUND: Gray platelet syndrome is a rare (about 40 cases published), inherited disorder characterized by a marked decrease or absence of platelet alpha-granules and platelet specific alpha-granule proteins. CASE REPORT: A boy, aged 4 years, presented with frequent ecchymoses. Acute idiopathic thrombocytopenia purpura was diagnosed because of his reduced platelet count (36,000/mm3) and recent viral infection. Intravenous gammaglobulin infusion was followed by a small rise in the platelet count (125,000/mm3). The patient was reinvestigated a few months later because of persistent thrombocytopenia and the failure of the immunologic treatment. The bleeding time was long and the platelets on blood smears appeared gray. Electron microscopy revealed numerous vacuoles and very few or no alpha-granules. Platelet aggregation and adhesion were normal, but stimulated platelets failed to liberate factor 4 and beta-thromboglobulin, while the plasma levels of beta-thromboglobulin were elevated. CONCLUSION: The frequency of gray platelet syndrome is probably underestimated in those diseases resulting in thrombocytopenia and this will continue until blood smears are thoroughly examined. Synthesis of platelet specific alpha-granule proteins seems normal; but these proteins cannot be stored as there are very few, or no alpha-granules. This abnormality could lead to increased levels of such proteins in the plasma.

Blood Platelet Disorders↗