Biomedical subjects

C Brodeur

Publications and source records attributed to C Brodeur.

5 recordsLinked to original sources

PubMed1997

Deficient DNA repair in chronic ulcerative colitis.

Carcinoma of the colon is a serious complication of chronic ulcerative colitis (CUC), a disease of unknown etiology. Peripheral blood lymphocytes from nine patients with CUC showed deficient repair of radiation-induced DNA damage compared with a group of healthy controls. DNA repair was measured indirectly by quantifying chromatid breaks after irradiation of cells with X-rays or ultraviolet during G2 phase of the cell cycle. Such breaks represent unrepaired DNA strand breaks that may arise directly from the damaging agent or indirectly during repair processes. Two types of deficiency were revealed. One was an abnormally high frequency of chromatid breaks after G2-phase X-irradiation. These may reflect deficient strand-break repair. The second deficiency was manifest as a low frequency of breaks not increased by addition of the DNA repair inhibitor araC. This low frequency apparently results from negligible incision activity. Deficient DNA repair in CUC may thus be a requisite predisposing factor for genomic instability and the potential development of colon carcinoma.

Adult↗

PubMed1992

Treatment of composite surfaces for indirect bonding.

Composite can be cured extraorally to fabricate indirect or direct/indirect restorations. These restorations are bonded to the tooth with a dual-cure resin cement. This study evaluated various methods for treating the surface of an indirect glass-filled composite to improve its bond to enamel. The methods tested were air abrasion (sandblasting), hydrofluoric (HF) acid etching, silanation, and combinations of these techniques. Shear bond strengths were measured for thermocycled and non-thermocycled specimens. Air abrasion, followed by silanation, provided the strongest and most consistent bonds. Etching with 9.6% HF gel decreased the bond strengths obtained by air abrasion. HF alone produced the weakest bonds, with most failures occurring adhesively between the indirect composite and the resin cement.

Air↗

PubMed1990

[Closing diastemas with direct technic].

Diastema closure by simple direct techniques has to take advantage of modern photo-cure systems. This paper reviews the basic concepts of diastema closure and describes a technique that does not necessitate the use a conventional matrix.

Composite Resins↗

PubMed1990

[The butterfly bridge: causes of debonding, 18 years clinical observation].

For 18 years, the acid-etched bridge has been put to good use. Clinical observations over this period of time allow us to take a step back and review this conservative technique. Using the results of clinical research, this article aims to evaluate the performance and basic principles relative to the acid-etched bridge. The primary and secondary causes of debonding are also identified.

Acid Etching, Dental↗

PubMed1988

Treatment of restless legs syndrome and periodic movements during sleep with L-dopa: a double-blind, controlled study.

Six patients with restless legs syndrome (RLS) and periodic movements during sleep (PMS) received placebo or L-dopa in a double-blind study. We recorded patients for 36 consecutive hours in the sleep laboratory during a baseline investigation and at the end of each treatment period. Daily evening questionnaires and a suggested immobilization test (SIT) performed at bedtime on each recording night documented the effect of L-dopa in RLS. A nocturnal EMG recording of the anterior tibialis muscles revealed the effect of L-dopa on PMS. L-Dopa proved effective in treating both RLS and PMS. Although not present in every patient, leg movements recorded during the SIT exhibited a clear periodicity. These observations support the hypothesis that RLS and PMS are two manifestations of the same central sensorimotor disorder.

Benserazide↗