[Protocol stress reduction children].
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Biomedical subjects
C Brons
Publications and source records attributed to C Brons.
[Cognitive functions and school achievement of children who were treated for acute lymphatic leukemia at a young age].
Neuropsychologic tests were performed in 40 children with acute lymphoblastic leukemia. They all had been treated at a young age with systemic chemotherapy, cranial irradiation and intrathecal methotrexate. The test results showed a high risk for learning disabilities. Visual motor integration problems were present early after cessation of treatment, but most cognitive defects became apparent about 2 years after stopping therapy. At that time 23% (9/40) of the children required special school types and 30% (12/40) needed additional help within their residential school. Problems with arithmetic were most prominent. Future study of patients who did not receive prophylactic irradiation of the brain will help to clarify the potential causative role of cranial irradiation in these cognitive defects.
Achievement↗
Study of the high-performance liquid chromatographic separation of reducing sugars, applied to the determination of lactose in milk.
The loss of reducing sugars by formation of Schiff bases on amino-bonded silica or on dynamically coated amino-silica columns was investigated at two column temperatures. Depending on the type, age and temperature of the column, these losses were in the range of 0-100%. A dimethylamino-bonded silica column did not cause loss of reducing sugars, but the retention of sugars was too weak to allow separation. The analysis of reducing sugars can be carried out on diol-modified silica with diisopropylethylamine in the eluent to enhance mutarotation. It is also possible to use a cation-exchange resin (Ca2+) column, equipped with a pre-column packed with a mixed-bed ion-exchange to remove interfering salts and acids. In combination with an acetate-acetonitrile sample clean-up, this method results in coefficients of variation of less than 1% for the determination of lactose in skim-milk.
Animals↗