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Biomedical subjects

C Brousseau

Publications and source records attributed to C Brousseau.

4 recordsLinked to original sources
PubMed1998

Effects of bacillus thuringiensis and destruxins (Metarhizium anisopliae mycotoxins) combinations on spruce budworm (Lepidoptera: tortricidae)

Laboratory bioassays were performed in order to assess the efficacy of a combination of a commercial preparation of Bacillus thuringiensis var. kurstaki (B.t.k.) (Thuricide) with destruxins (Metarhizium anisopliae mycotoxins) on the fifth instar of Choristoneura fumiferana Clemens. Lethal doses were determined for each microbial agent and used as a basis for the bioassays involving a combination of the two agents. Interaction or the lack of interaction was determined by comparing the observed and the theoretically expected mortality rates. Seven out of 10 different combinations demonstrated synergism between the two agents. The modelization applied on results allowed us to establish the following general equation: LDmixture = 1.259(LDDx) + 1.129(LDBt) - 0.016(LDDx)(LDBt) + 12.196. Such an equation explains the relationship which exists between the two lethal agents (R2 = 0.99). Our results suggest that the two agents contribute to the synergism in the system and that a combination of both could be an efficient means of controlling C. fumiferana populations and of reducing the dose of B.t.k. which is usually required for such a control. Copyright 1998 Academic Press.

Journal Article↗
PubMed1988

Myalgia in outpatient surgery: comparison of atracurium and succinylcholine.

We studied 60 outpatients randomly divided into two groups. Anesthesia was induced with fentanyl 1.5 micrograms.kg-1 plus thiopentone 5-7 mg.kg-1. Patients in Group I were intubated with the aid of succinylcholine 1.5 mg.kg-1 after pre-treatment with d-tubocurarine 0.05 mg.kg-1. Group II received atracurium 350 micrograms.kg-1 three minutes after a priming dose of 50 micrograms.kg-1. Anesthesia was maintained with isoflurane 1-2 per cent in a mixture of nitrous oxide 60 per cent and oxygen 40 per cent. No supplemental doses of fentanyl or atracurium were given. Intubation conditions were satisfactory for all patients in both groups. There was no significant difference in intubation score between the two groups. The incidence of myalgia was 76 per cent in the succinylcholine group compared to 23 per cent in the atracurium group (p less than 0.005). Fifty per cent of the patients in the succinylcholine group had myalgia necessitating bed rest or analgesics compared to 23 per cent in the atracurium group (p less than 0.05). We conclude that atracurium is a suitable neuromuscular relaxant for outpatient surgery and that myalgia is a major morbidity factor in this population that can be reduced by the use of atracurium instead of succinylcholine.

Adolescent↗