PubMed Health⌕ Search

Biomedical subjects

C Bruce

Publications and source records attributed to C Bruce.

88 records · Page 5Linked to original sources
PubMed1980

Uptake and distribution of halothane in dog blood.

The uptake and distribution of halothane in dog blood were studied by analysing the whole blood and plasma concentrations of halothane in samples of arterial and mixed venous blood at different times after the induction of anesthesia with constant inspired halothane levels of 1.0, 1.5, 2.0, and 2.5%, respectively. In general a steady state was reached 2-3 h after induction. Comparison of the arterial blood concentration calculated from end-tidal halothane partial pressure with that determined by direct analysis of the blood indicated that halothane in the alveoli and halothane in arterial blood are not in thermodynamic equilibrium. The arterial halothane concentrations calculated from the end-tidal halothane partial pressure assuming equilibrium is much higher than those found experimentally; thus end-tidal halothane partial pressure is not a true measure of blood halothane concentration. The distribution of halothane between the plasma and cells in blood appeared to be sufficiently rapid to be independent of the approach to the steady state.

Anesthesia↗
PubMed1979

An improved radioenzymatic assay for histamine in human plasma, whole blood, urine, and gastric juice.

A radioenzymatic method suitable for the assay of histamine in human blood, urine, plasma, and gastric juice is described. It differs from earlier methods by use of a histamine methyltransferase preparation from pig brain, of high activity tritiated S-adenosylmethionine, and of a heat precipitation step to reduce the previously noted interference from plasma constituents. The method is simpler than those requiring solvent extraction and concentration of histamine, gives recoveries in the range 80-120%, and so sliminates the need for internal standardisation. The method is sensitive and precise with coefficients of variation for blood, urine, and plasma of 5%, 6%, and 13% respectively. The mean +/- standard deviation for normal human plasma histamine is 5 +/- 4 nmol/l, for whole blood 559 +/- 193 nmol/l, and for urine 229 +/- 128 nmol/24h.

Animals↗
PubMed1977

Sodium nitroprusside-induced hypotension and renal blood flow.

Hypotension produced by sodium nitroprusside during halothane anaesthesia in a series of experiments in dogs was accompanied by the maintenance of renal blood flow. Renal blood flow was maintained at levels of systemic pressure at which flow is customarily reduced in man and experimental animals. The significance of this observation is the possibility that sodium nitroprusside has a protective effect on the kidney, not only in states of deliberate hypotension, but in other low flow states where renal perfusion and function may be compromised.

Anesthesia↗
PubMed1976

The effects of furosemide on remal blood flow and cortical perfusion during methoxyflurane and halothane anaesthesia.

Nephrotoxicity due to methoxyflurane may be due in part to alterations in intra-renal perfusion. Furosemide is believed to alter the intra-renal distribution of blood flow. Studies have been carried out to observe the effects of systemic furosemide administration during methoxyflurane and halothane anaesthesia in normotensive animals and in animals made hypotensive by increasing inspired concentrations of the anaesthetics. During halothane anaesthesia normotensive dogs showed a rise in total renal blood flow during the infusion of furosemide. Hypotensive dogs showed no increase in flow. During methoxyflurane anaesthesia no change in total renal blood flow followed furosemide administration to normotensive animals. Some diminution in total blood flow followed the administration of furosemide in hypotensive dogs during methoxyflurane anaesthesia. In normotensive dogs during halothane anaesthesia there was a significant increase in deep cortical perfusion after furosemide. Furosemide, therefore, is unlikely to mitigate the potential for nephrotoxicity which methoxyflurane possesses. Furthermore, this diuretic may adversely influence renal function when administered during halothane anaesthesia.

Anesthesia, Inhalation↗
PubMed1976

Dobutamine and general anaesthesia: a study of the response of arterial pressure, heart rate and renal blood flow.

The effects of dobutamine, a new catecholamine, have been studied during anaesthesia with halothane, halothane and nitrous oxide and alphaprodine. Renal blood flow is increased by dobutamine as are mean arterial pressure and heart rate. The increase in rate is less marked during alphaprodine anaesthesia than when halothane is administered. Dobutamine may prove a useful agent in the management of acute circulatory failure but it is capable of inducing dysrhythmias under the conditions of these experiments.

Alphaprodine↗
PubMed1976

Histamine levels in plasma, blood, and urine in severe asthma, and the effect of corticosteroid treatment.

Plasma, whole blood, and urinary histamine levels have been determined in 64 normal subjects, in 10 patients with severe asthma, and in 10 control patients with other illnesses. The mean whole blood levels did not differ between the three groups. The mean plasma level in the asthmatics was significantly greater than that of the normal subjects but not of the control patients. The urinary histamine output was lower in the control patients than in the normal subjects but in the asthmatics did not differ from that of the normals. Corticosteroid therapy caused a marked fall, often to barely detectable levels, of the whole blood histamine concentration of the asthmatic patients and restored the plasma levels to normal but did not affect urinary histamine levels.

Adult↗
PubMed1976

Importance of obstetrics in a comprehensive family practice.

Four family practices in the San Francisco Bay Area, two of which did not include obstetrics and two of which did, were examined with reference to their patient populations and to the number of families for which they provided comprehensive, continuous family care. The groups practicing without obstetrics were found to do acute care primarily and, to a lesser extent, long-term care internal medicine, with very little pediatrics or gynecology. The groups practicing with obstetrics did significantly more minor surgery, gynecology, pediatrics, and psychotherapy. During the six-week study, the group practicing with obstetrics saw five times as many patients who were members of families receiving continuous, comprehensive care from the practice under observation. Psychotherapy done by the group including obstetrics was primarily family therapy; for the other group, individual therapy. If larger studies support these findings, then important implications are suggested for training programs in family practice and for the resident deciding to enter practice.

Adult↗
PubMed1970

Effects of teacher attention on attending behavior of two boys at adjacent desks.

The effects of teacher attention on the attending behavior of two boys seated at adjacent desks were investigated. Baseline records were obtained of the appropriate attending behavior of two boys who were described as the most disruptive pupils in a second-grade classroom of a poverty area school. During the first experimental phase, the teacher systematically increased the amount of attention for appropriate attending in one of the pair, Edwin. This resulted in a dramatic increase in his attending rate and a lesser, though significant, increase in attending behavior of the second boy, Greg. During the second experimental phase, systematic attention for attending was instituted for Greg and was discontinued for Edwin. This resulted in further increases in attending by Greg and a reduction in attending by Edwin. A brief withdrawal of reinforcement for attending in both Greg and Edwin reduced attending levels for both. Following this reversal appropriate attending for both boys was systematically reinforced and attending returned to high levels.

Journal Article↗
PubMedDate not supplied

Are we being served?

Explore the source record for details and available documents.

Appointments and Schedules↗
PubMedDate not supplied

A radiographic survey of dental anomalies in Black pediatric patients.

During seemingly routine check-ups, the dental practitioner must be ever aware of "quiescent" abnormalities or irregularities. Knowledge of special problems occurring within a certain patient population is of great value to the practitioner when evaluating the individual patient. Numerous studies have been conducted evaluating the pediatric Caucasian population; however, no comparable studies for the Black pediatric population have been done. This study sought to establish prevalence rates for the Black pediatric population with regards to the following anomalies: congenitally missing teeth, supernumerary teeth, dens in dente, odontomas, dentinogenesis imperfecta, gemination, fusion and concrescence. The radiographs (panographs mandatory), history forms and treatment progress records of 2,267 children (1,136 males and 1,131 females) were analyzed. Radiographs of poor quality were eliminated and attempts were made to include only children of Black American heritage. Prevalence rates established for a predominantly Black pediatric population were: 4.4%, congenitally missing teeth; 1.49%, supernumerary teeth; 0.26%, dentinogenesis imperfecta (Brandywine type); 0.44%, odontomas; 0.22%, gemination; and 0.12%, fusion. Evidence of dens in dente was found in only one erupted supernumerary maxillary paralateral, and the detection of only one case of concrescence occurred; both have prevalence rates of 0.04%. No other study has produced such a high rate of dentinogenesis imperfecta (.26%), except that conducted within the tri-racial group itself. In addition, if assumptions are to be made from this investigation for the general population, supernumeraries and odontomas may be present significantly more often in the Black than Caucasian pediatric population.

Adolescent↗