[Blood donation: a constantly evolving concept].
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Biomedical subjects
Publications and source records attributed to C Buñuel.
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PURPOSE: To determine if the investigation of previous clinical features through an inquiry could be useful to predict HCV infection in blood donors as assessed by recombinant immunoblot assay. MATERIAL AND METHODS: From january 1990 to august 1991, 79 HCV seropositive blood donors by recombinant immunoblot assays (58 RIBA 1 and 21 RIBA II) were selected to be inquired and to perform a clinical examination. The inquiry included the following parameters: age, sex, social environment, history of liver disease, presence or absence for parenteral risk factors (surgery, blood transfusion, odontological procedures, acupuncture, tattoos, etc...). RESULTS: 1) General data: mean age, 43 years (range 20-65); male/female 54/25 (ratio 2.16); urban/rural environment 50/29 (ratio 1.72); new/regular blood donors 17/62 (ratio 0.27). 2) Inquiry results: In seven cases (8.9%) previous symptoms were detected. Hepatic stigmata were present in 12 donors (15.2%). A 67.0 showed previous surgical procedures; 48.1% had odontological history; 24.0% were recipients for blood transfusion; parenteral treatment using nondisposable material were detected in 19 cases (24.0%); acupuncture in 4 donors (5.0%); tattoos in only one case. Social habits were: alcoholic consumption in 44.3% and regular medicine ingestion in 19.0%; a 81.0% had a unique partner and a 8.9% preferred multiple heterosexual contacts. A 29.1% inhabit in unfamiliar house and the remaining 70.9% lived in apartments buildings; the mean of family members was 3.7 persons (range 2-8). REMARKS: a) It is pointed out the scarce and physical expression of the HCV infection. So in many aspects the inquiry is useless and time consuming. b) Nevertheless, we have detected some parenteral risk factors in seropositive cases. Regarding this particular aspect the inquiry is useful. Taken into account the previous we suggest to add an item with the parenteral risk factors to the ordinary self-answering inquire, addressed to all blood donors in each donation.
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A study was carried out in 2,000 blood donors aimed to assess the incidence of anti-C hepatitis virus antibodies. Of the total number of samples, 10 cases were found positive (0.5%), a figure lower than the national average. Of these 10 cases, ALT levels were high in 5 (0.2%). The potential risk of post-transfusion C hepatitis increases in accordance with the number of blood units transfused. This incidence of anti-C hepatitis virus antibodies is discussed with regard to previous findings in other countries, the incidence of positive donors being also very low.
Forty-eight girls with Turner's syndrome were assigned to one of three treatments; recombinant human growth hormone (rhGH) alone, rhGH plus oxandrolone, and rhGH plus ethinyloestradiol. Treatment with rhGH alone or in combination with oxandrolone induced catch-up growth. Older girls treated with rhGH plus ethinyloestradiol showed less marked improvement. The gain in height was associated with a gain in bone diameter and cortical thickness (reflecting increased bone mass). There was a rapid loss of subcutaneous fat. These effects of growth hormone are similar to those observed in patients with growth hormone deficiency.
The prolonged evolution of a case of pseudohypoparathyroidism with hereditary osteodystrophy (AHO) and osteitis fibrosa is presented. The diagnosis was confirmed by the existence of a peculiar phenotype, hypocalcaemia, hyperphosphatemia, increased PTH values, and a lack of tubular response after PTH and radiological signs of hyperparathyroidism. The clinical and biochemical evolution, under 1.25 (OH)2D3 therapy with special emphasis on the growth and development were shown. The bibliography was also reviewed.
We present three cases of Caffey's disease, which have been observed in a family and a previous one former generation of the same family. A review of the literature upon family cases is carried out (35 families with 143 patients) prevailing the hypothesis of the type of autosomal dominant trait with incomplete penetrance and variable expressivity. HLA system is studied in such a family without common haplotypes being found and therefore the trait does not seem to be linked to genes of this system.
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