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Biomedical subjects

C Buck

Publications and source records attributed to C Buck.

17 recordsLinked to original sources
PubMed1992

Androgen concentrations in expressed prostatic secretions: no correlation with tissue levels.

In an attempt to determine whether the androgen profiles of the prostate fluid (EPS) mirror the concentrations in the prostate tissue, we have measured testosterone and dihydrotestosterone (DHT) in EPS and correlated their levels to the concentrations found in hyperplastic prostate tissue (BPH) obtained from the same 19 patients. Although androgen concentrations in EPS were very high (testosterone = 106.7 +/- 81.9 ng/g dry weight; DHT = 54.2 +/- 11.2 ng/g dry weight), they did not reflect the concentrations measured in BPH tissue (testosterone = 7.56 +/- 1.54 ng/g dry weight; DHT = 10.54 +/- 0.63 ng/g dry weight). Additionally the accumulation of tissular DHT usually associated with BPH was not mirrored in the EPS specimens which demonstrated a relatively higher concentration of testosterone when compared to DHT. In EPS, there was also a very strong correlation between testosterone and DHT concentrations (r = 0.89; P less than 0.01). We have also measured zinc concentrations in EPS and BPH tissue but were unable to detect any relationship between the two parameters. Significantly, however, EPS zinc concentrations showed a close correlation with EPS testosterone (r = 0.73; P less than 0.01) and DHT (r = 0.69; P less than 0.01) concentrations.

Body Fluids↗
PubMed1992

Concerted evolution of the mouse Tcp-10 gene family: implications for the functional basis of t haplotype transmission ratio distortion.

The mouse Tcr locus is defined by its central role in the transmission ratio distortion phenotype characteristic of t haplotypes. A molecular candidate for Tcr has been identified in the form of a gene--Tcp-10b--expressed during spermatogenesis. Tcp-10b is one member of a multigene family present in two to four copies on different homologs of chromosome 17. The coding regions of the Tcp-10 genes present within two inbred strains were compared with those of the tw5 haplotype. The various gene family members are highly conserved relative to each other with a minimum nucleotide identity of 98.6% in all pairwise comparisons. Maximal parsimony analysis indicates that the Tcp-10 gene family has evolved in a concerted manner with the obliteration of nearly all individual gene-specific characteristics. As a consequence, the candidate for the full-length mutant Tcr gene product is distinguished by only a single, highly conservative, amino acid change. The data are consistent with the hypothesis that the effector of mutant Tcr activity is a second, alternatively spliced product that is expressed in a haploid- and allele-specific manner.

Alleles↗
PubMed1978

Radiotherapy of mycosis fungoides: twenty years of experience with teleroentgen and low-voltage X-ray therapy.

Of 98 patients with mycosis fungoides, 55 have been treated with teleroentgen therapy and 43 with low voltage radiation at a shorter distance. Teleroentgen therapy is indicated in the stage of generalized eczematous lesions or superficial infiltration. According to the Hamburg method, a dose of 300 R was delivered to eight fields at a target distance of 120 cm. After a series of one to three treatments, 300 R, administered at three-week intervals, all lesions usually cleared. Small patches and deeply infiltrated lesions and tumors were treated with the same doses and intervals of low voltage X rays, the half-value depth corresponding to the depth of infiltration. After five years, 54% of all patients were still alive and after 10 years, 29% were still living.

Adult↗
PubMed1978

Season of birth among the sibs of schizophrenics.

The season of birth distribution of 1,039 sibs of Canadian schizophrenic patients was compared with that of births in the Canadian general population over the same time period. The excess of winter births observed among the schizophrenics was not found among their sibs.

Canada↗
PubMed1977

Survival of nieces and nephews of schizophrenic patients.

Evidence was found against the hypothesis that heterozygous carriers of a schizophrenic gene have a reproductive advantage through enhanced fertility. In consequence an investigation was made of the possibility that an advantage is gained through diminished early mortality among the off-spring of carriers. The results were equivocal. While an observed deficit of infant deaths was attributable to under-reporting, the possibility of a true advantage could not be ruled out, because of the statistical unreliability of the findings in a sample of the size available. A plea is made for a collaborative effort to settle the issue.

Adolescent↗
PubMed1977

Users and non-users of doctors--implications for self-care.

Sixty patients who visited their general practitioner were matched with 60 patients registered with the same doctor, who were of the same sex and in the same ten-year age group, and who had not visited the doctor for at least one year, but had recently experienced symptoms similar to those presented by the attending patients.Comparison of the 60 pairs revealed the following differences, all substantial although not all statistically significant. The patients who visited the doctor perceived themselves as less healthy, fewer had attempted self-treatment, more reported serious personal problems, and fewer reported obstacles to visiting the doctor.Differences between the pairs were negligible for total number of current ailments, effectiveness of self-treatment, if used, optimism about the healing powers of doctors, and fear of troubling their doctor with trivia.

Attitude to Health↗
PubMed1975

Popper's philosophy for epidemiologists.

This paper discusses the application of Popper's philosophy to epidemiological research, examining in particular the problems of replication without risk of refutation, of mistaking statistical sophistication for deductive inference, and of dealing with causality at a general level. An example is given of a Popperian approach to the test of a causal hypothesis concerning cancer of the cervix.

Adolescent↗
PubMed1975

A controlled prospective study of the effect of endurance training on the recurrence rate of myocardial infarction. A description of the experimental design.

A multicenter prospective study has been designed to determine whether participation in an exercise program which produces a significant training effect will affect the recurrence rate in men who have survived an initial myocardial infarction. The control group consists of subjects who participate in a program involving low intensity activities designed to avoid a significant training effect. The subjects will be followed for a period of 4 years and a reduction of 50 per cent in the risk of recurrence will be considered clinically significant. The criteria for entry, the method of allocation, the structure of the exercise program and method of assessing cardiorespiratory fitness are described.

Angina Pectoris↗
PubMed1975

Fertility of the sibs of schizophrenic patients.

This investigation has provided evidence against the hypothesis that heterozygous carriers of schizophrenic gene have a reproductive advantage through enhanced fertility. An advantage arising from lower mortality between birth and the end of the reproductive period was not investigated, but should be examined before we search for other explanations of the apparently stable polymorphism of schizophrenia.

Age Factors↗