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Biomedical subjects

C Burillon

Publications and source records attributed to C Burillon.

At least 19 recordsLinked to original sources
PubMed2006

[Perforating ocular injuries in children: a retrospective study of 57 cases].

PURPOSE: The purpose of this study was to investigate the current causes and outcomes of open eye injuries in children. PATIENTS AND METHODS: We reviewed the hospital records of 57 patients under 14 years of age who were treated for open globe injuries at Edouard Herriot Hospital, Lyon, France, between January 1999 and December 2003. RESULTS: This review includes 57 patients: 41 males and 16 females. The mean age at admission was 6.8 +/- 3.5 years. The injury involved the right eye in 27 cases and the left eye in 30 cases. Sharp or pointed objects accounted for the majority of injuries. The most common location for a perforating ocular injury to occur was at home. Wounds involved the cornea in 41 cases. There was iris hernia in 21 cases, hyphema in 15 cases, vitreous prolapse in 14 cases, lens damage in 12 cases, and shallow anterior chamber in 11 cases. The most frequent complication was traumatic cataract. Secondary lens removal was performed in 15 cases. Visual acuity was 0.5 or better in 27 of the 57 eyes, with a mean follow-up period of 12 months. CONCLUSIONS: Perforating ocular injuries are a frequent cause of unilateral visual loss. The highest proportion of injuries occurred at home and sharp objects were the most frequent causative agents. More adequate adult supervision and educational measures are necessary in order to reduce the prevalence of these accidents.

Adolescent↗
PubMed2006

[Bacterial adhesion to intraocular lenses and endophthalmitis prevention: review of the literature].

Bacterial adhesion to intraocular lenses (IOLs) during their implantation is a major etiological factor of postoperative endophthalmitis. Polypropylene was the first biomaterial that allowed this relation of cause and effect between bacterial adhesion and endophthalmitis to be proven. Adhesion to IOLs has been investigated in several in vitro studies, with contradictory results reported, due to variations in experimental conditions: the incubation times and the methods all varied. Adhesion is affected by the type of IOL, the bacterial strains, and the surrounding medium. Since this medium is very difficult to model because of its complexity, in vivo studies seemed essential. We have recently determined in vivo progression in the amount of adhering Staphylococcus epidermidis to five types of IOLs. There have been few epidemiological studies published to determine the relationship between endophthalmitis and the IOL type. However, the perfect biomaterial that could prevent postoperative endophthalmitis does not yet exist. Globally, hydrophilic materials and hydrophobic acrylic seem to be less sticky than silicone or PMMA, but this remains to be proven clinically.

Bacterial Adhesion↗
PubMed2005

Coats' disease and bilateral cataract in a child with Turner syndrome: a case report.

PURPOSE: To report the first case in which Coats' disease was observed with infantile cataract in a girl with Turner syndrome (TS). MATERIALS AND METHODS: We examined a 4-year-old female infant with TS who was referred with a diagnosis of leukocoria in the left eye. RESULTS AND DISCUSSION: Examination under anaesthesia revealed a bilateral punctate cataract and left eye fundus showed vascular retinal abnormalities typical of Coats' disease. Cryotherapy was performed on the telangiectatic vessels and the child was followed up for a period of 12 months. Despite cryotherapy resulting in regression of the peripheral exudates, an exudative maculopathy persisted with poor visual outcome. We suggest that Coats' disease should be considered as a rare ocular manifestation in TS.

Cataract↗
PubMed2005

[Conjunctival tumors in children. A histopathologic study of 42 cases].

PURPOSE: The aim of this study was to describe the clinicopathological characteristics of 42 conjunctival tumors surgically removed in children. PATIENTS AND METHODS: Records of all conjunctival tumors surgically removed in children during the 11-year period 1990-2001 were collected from the records of the Department of Ophthalmology, Edouard Herriot Hospital, Lyon. In all cases, the tumor was resected with no additional treatment. Sections of all cases were reviewed by the same pathologist. RESULTS: A total of 42 cases (40 patients) were included in the study. The mean age of the subjects at the time of surgical excision was 10 years, with a range of 1-17 years; 45% were male. The most frequent indication for tumor removal was suspected growth. The clinical diagnosis was accurate in 91% of cases. The tumor was localized at the limbus in 57% of cases. Most tumors were pigmented nevi, accounting for 83% of the lesions. The histopathological diagnoses in decreasing order of frequency were: nevi (35), angioma (2), dermolipoma (2), dermoid (1), papilloma (1), and squamous cell carcinoma (1). In one case, the histological study revealed squamous cell carcinoma in a child suffering from xeroderma pigmentosum. CONCLUSIONS: This retrospective study suggests that malignancy of pigmented conjunctival lesions is extremely rare in children. Although squamous cell carcinoma is rare in children, surgical excision and histological study are necessary when a conjunctival lesion is associated with xeroderma pigmentosum or immunodeficiency.

Adolescent↗
PubMed2005

[Opacification of a hydrophilic acrylic intraocular lens].

PURPOSE: To report pathological and histochemical analysis of an explanted opacified hydrophilic acrylic intraocular lens. PATIENTS: and method: A hydrophilic acrylic intraocular lens--Orion IFP3D6--was explanted 2 years after routine phacoemulsification because of its opacification associated with significant visual impairment (20/40). The intraocular lens was examined by gross and light microscopy. Full-thickness cut sections of the lens were stained with 1% alizarin red (a special stain for calcium). RESULTS: Microscopic analyses revealed the presence of granules of various sizes distributed in a line parallel to the anterior and posterior curvatures of the lens. The granules stained positively for alizarin red. CONCLUSION: Such opacification has been described with the SC60B-OUV, MDR Inc., which is also a one-piece foldable-design intraocular lens (28% hydrophilic material). The opacification of the intraocular lens occurred over various periods after surgery. Forty percent of these lenses have been explanted. Microscopic and histochemical evaluation of these intraocular lenses revealed the same type of granulation deposits within the lenses. The origin and mechanism of the opacification are still not fully understood.

Female↗
PubMed2005

[Staphylococcus epidermidis biofilms on intraocular lens surface: review of the literature].

Bacterial adhesion to intraocular lenses (IOLs) takes place during their implantation. This is a prominent etiological factor of postoperative endophthalmitis. Following adhesion, secretion of an extracellular matrix (called slime for Staphylococcus epidermidis) and formation of multiple layers of microcolonies lead to the colonization of the biomaterial surface. Scanning electron microscopy photographs illustrate the different steps of biofilm formation. The different adhesins expressed by S. epidermidis involved in the adhesion process are described. The biofilm is not only an adhesive medium; it also affects virulence. Last, notions on biofilm physiology are discussed in an attempt to explain the dynamic equilibrium of this system. In 2004, the perfect biomaterial able to prevent postoperative endophthalmitis does not yet exist. Moreover, there is no effective tool, at the present time, to fight against mature biofilms. Therefore, preventing biofilm formation remains capital, which requires perfect knowledge of all stages of formation and the factors involved.

Bacterial Adhesion↗
PubMed2005

[Prospective study of contrast sensitivity and visual effects after LASIK].

PURPOSE: To evaluate changes in visual effects (contrast sensitivity, halos, and glare) following laser in situ keratomilleusis (LASIK). PATIENTS AND METHODS: In this prospective study, 72 eyes had LASIK to correct myopia. Contrast sensitivity was tested preoperatively, as well as 6 and 12 months postoperatively. The spatial frequencies tested were 3, 6, 12, and 18 cycles per degree (c/d). There were two groups: group 1 for myopia between -6 D (n=30) and -7.5 D and group 2 for myopia between -7.5 D and -10 D (n=25). There were 17 cases with loss of sight. For each visit, pupil diameter, halos, and glare were measured. RESULTS: Contrast sensitivity was better in group 1 than in group 2 (p<0.05) (for spatial frequencies of 3, 12, 18, c/d). In group 1, contrast sensitivity decreased 6 months postoperatively for all spatial frequencies (p<0.05); 12 months after surgery the changes were not significant. In group 2, changes were not significant. For halos and glare, pre- and postoperative percentages were not different. There was no correlation with pupil diameter. CONCLUSIONS: After LASIK to correct myopia, there may be a persistent decrease in contrast sensitivity. Changes are only significant at 6 months postoperatively. Patients should be informed preoperatively of this possible decrease in functional vision.

Adult↗
PubMed2005

[Endophthalmitis: pathogenesis and antibiotic prophylaxis].

Postoperative endophthalmitis is still one of the most fearsome complications of cataract surgery. The present review's aims are to study the etiology and pathogenesis of endophthalmitis and the criteria for antibiotic prophylaxis. Endophthalmitis prevalence is 0.07%-0.32% in cataract surgery. The clinical presentation needs to be perfectly known, even if none of the signs is pathognomonic. Bacteria predominantly cultured in postoperative endophthalmitis are gram-positive, especially Staphylococcus epidermidis. Most of the bacteria come from the patient. Bacterial adhesion to intraocular lenses (IOLs) takes place during their implantation, a prominent etiological factor. Polypropylene was the first biomaterial that proved this relation of cause and effect between bacterial adhesion and endophthalmitis. The benefit of antibiotic prophylaxis during cataract surgery has yet not been proven, since the low prevalence of endophthalmitis makes controlled studies with a large cohort difficult. The criteria and the four possible administration approaches (topical, subconjunctival, irrigation liquid, systemic) are analyzed.

Anti-Bacterial Agents↗
PubMed2005

[Keratoglobus: review of the literature].

Keratoglobus is a rare bilateral condition characterized by a globular protrusion of the cornea. The cornea remains transparent and shows a generalized thinning, most pronounced in the periphery. Most often keratoglobus is a congenital disease, but it may be secondarily acquired. This corneal pathology causes severe visual impairment: it induces extreme myopia, irregular astigmatism, and corneal scarring due to previous hydrops. Spectacle corrections are utilized as long as they provide adequate visual function. Surgery is performed when visual needs are no longer satisfied. However, surgical management of this disease is difficult because of the extreme thinness of the entire cornea. Penetrating keratoplasty is one of the first surgical approaches to have been tested, but it has been partly renounced in favor of more complex procedures. Optimal surgical treatment for keratoglobus remains unknown because of the scarcity of reported surgical results.

Humans↗
PubMed2004

[Retinopathy of prematurity. Results of fundus examination performed in 94 preterm infants].

PURPOSE: The purpose of this study was to evaluate the incidence and severity of retinopathy of prematurity (ROP) in infants of birth weight less than 1.500 g and/or under 32 weeks'gestation. METHODS: Ninety-four preterm infants were examined following the Royal College of Ophthalmologists guidelines and retinopathy was graded using the International Classification of ROP. Screening limits were 1 500 g birth weight or 32 weeks'gestational age. Fundus examinations for ROP were performed at 5 weeks'chronological age from birth. Pupil dilation was obtained with instillation of 1% tropicamide three times at 15-minute intervals. RESULTS: The 94 infants examined for ROP had a median gestational age of 292.3 weeks and a median birth weight of 1 110340 g. ROP was diagnosed in 21 of 94 subjects (22.3%) by fundus examination. ROP stage 3 developed in one preterm infant, ROP stage 2 developed in five preterm infants, and ROP stage 1 developed in 15 preterm infants. No premature babies developed stage 4 or stage 5 ROP. The disease regressed spontaneously in all cases and none of the infants required cryo/laser therapy. In the most premature infants, 23-26 weeks'gestation, 57% developed ROP and one developed severe ROP (stage 3). No disease more posterior to peripheral zone 2 was observed. The incidence of ROP was higher in infants exposed to greater than 21% oxygen (24.2%) than in infants who did not receive oxygen (17.8%). Oxygen, blood transfusion, and cardiopathy appear to be associated with an increased incidence of retinopathy of prematurity. CONCLUSIONS: ROP continues to be a common problem associated with prematurity in France. This study found a similar incidence of prethreshold ROP when compared to recent studies. The data showed that blood transfusion and cardiopathy may play a role in the development of ROP in premature infants.

France↗
PubMed2004

[Buphthalmia secondary to congenital pigmented epithelial iris cyst].

We report the case of a 2-day-old child with buphthalmia caused by a congenital pigmented epithelial iris cyst. The use of ultrasound biomicroscopy (UBM) and high-resolution echography (20MHz) specified the diagnosis before general anesthesia for complete examination and treatment. Surgery can control intraocular pressure and the opening of the visual axis; there is, however, relative amblyopia. This case confirms the advantage of UBM in examining tumors of the anterior segment. The early diagnosis, facilitated by use of the UBM, provided quick and well-adapted treatment.

Cysts↗
PubMed2004

[Femtosecond laser: a micromachining system for corneal surgery].

INTRODUCTION: The authors present the diode-pumped, all-solid state, neodymium:glass femtosecond laser from the Laboratory of Ocular Biotechnology, Hotel-Dieu Hospital. MATERIALS AND METHODS: We worked with a 1,065-nm wavelength infrared laser. This laser is composed of an oscillator and amplification glass matrix mixed with neodymium. Its stretching and compression system is capable of producing pulses lasting a few hundred femtoseconds. The repetition rate is adjustable, ranging from 1 to 10 kHz, and can reach energies up to 60 microJ. The delivery system was set up on an optical table, with human corneal samples fixed to an anterior chamber system, which can be moved over the X-Y-Z axis by a computer-guided translation motor with micrometric precision. We analyzed the biological effects of laser impacts in human corneal tissue, obtained from the French Eye Bank. RESULTS: The femtosecond laser provides automated corneal cutting with a high level of precision, which can be verified on the corneal surface regularity by scanning electron microscopy analysis. Silicon samples can also be cut and can be used for calibration testing of the laser. CONCLUSION: The set-up composed of the femtosecond laser and the described delivery system enable precise corneal cutting and offer the opportunity to study its characteristics.

Calibration↗
PubMed2004

[Purtscher retinopathy in acute alcoholic pancreatitis. A case report].

Purtscher retinopathy is a retinal vasculopathy most commonly caused by head or chest trauma. The most frequent signs include white ischemic infarcts (cotton-wool spots) and retinal hemorrhages (intraretinal, preretinal, or flame). The signs of ischemic vasculopathy predominate in the interpapillomacular zone. We report a case of a 31-year-old woman with sudden bilateral loss of vision caused by Purtscher retinopathy in acute alcoholic pancreatitis.

Acute Disease↗
PubMed2004

[Other surgical therapies for cornea burns].

With limbal stem cell and amniotic membrane transplantations, penetrating keratoplasty is the most important treatment of severe corneal burns. In the acute stage, re-epithelialization failure and resultant stromal ulceration can induce corneal perforation. A lamellar or a full-thickness patch graft is indicated in order to preserve the eyeball. For small perforations, tissue adhesive can be used. In the early reparative stage, keratoplasty has its place, but corneal vascularization is a major risk factor for graft rejection. Lamellar keratoplasty is preferred because it provides tectonic support. After several graft failures, a keratoprosthesis is the last solution for these bilaterally affected patients, but evisceration cannot be always avoided.

Cornea↗
PubMed2004

Intraocular lenses, bacterial adhesion and endophthalmitis prevention: a review.

Postoperative endophthalmitis following intraocular lens (IOL) implantation is still one of the most feared complications of cataract surgery. Bacterial adhesion to IOLs during their insertion is a prominent etiological factor. Polypropylene was the first biomaterial that allowed this relation of cause and effect to be proven. Following adhesion, bacteria replicate, congregate and form multiple layers of microcolonies which actually represent the basic structural unit of the biofilm. The bacteria are embedded in a slime layer. Personal photographs illustrate the different steps of biofilm formation. This slime matrix is not only an adhesive medium; it also affects virulence. Adhesion to IOLs has been studied by several in vitro studies and discrepancies can be found between them which are due to variations of experimental conditions. The strains, the incubation times and the methods all varied. Adhesion is affected by the nature of the IOLs, the isolates and the surrounding medium. Since this medium is very difficult to model because of its complexity, in vivo studies seemed essential. We have recently determined in vivo evolution of the amount of attached bacteria to five types of IOLs. Crystalline lenses from 90 domestic pigs were removed aseptically and replaced with previously infected IOLs. There have been few epidemiological studies published to determine the relationship between endophthalmitis and the IOL type. However, the perfect biomaterial that could prevent postoperative endophthalmitis does not yet exist. Globally, hydrophilic materials and hydrophobic acrylic seem to be less sticky than silicone or PMMA, but this remains to be proven clinically.

Animals↗
PubMed2003

[The genetics of hereditary cataract].

Congenital cataracts are an important cause of visual impairment in children. Approximately one-third of congenital cataracts are hereditary. The disease, when inherited as an isolated abnormality, is phenotypically and genetically heterogeneous. Autosomal dominant forms with high penetrance appear to be the most common. To date, thirteen genes have been implicated in cataractogenesis. The identification of the genetic mutations causing congenital cataracts will provide a better understanding of cataractogenesis in childhood and provide further insights into normal lens development.

Aquaporins↗