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Biomedical subjects

C Burtin

Publications and source records attributed to C Burtin.

At least 55 records · Page 3Linked to original sources
PubMed1981

In vitro influence of theophylline on anti-IgE-induced release from leucocytes and whole blood in asthmatic children.

Two groups of asthmatic children were found with regard to the influence of theophylline on the anti-IgE-induced histamine release from whole blood. In th first group (21 children), histamine release was obtained both from whole blood and washed leucocytes and was inhibited by 10(-4) M theophylline. In the second group (5 children), histamine release required the presence of plasma and was not inhibited by 10(-4) M theophylline. Theophylline treatment was efficacious only in children of the first group.

Adolescent↗
PubMed1981

The influence of intraperitoneal injections of histamine on tumour growth in fibrosarcoma-bearing mice.

Twenty C57BL/6 male and 20 C3H female mice carrying a methyl cholanthrene-induced fibrosarcoma received, daily, intraperitoneal injections of histamine dihydrochloride (1.8 mg or 6 mg histamine base/mouse). In all histamine-treated C57BL/6 mice, tumour growth was significantly slower than in control mice until day 18. Thereafter, the tumour growth rate of treated compared to control mice was accelerated. In 10 out of 20 C3H mice, tumour growth was significantly slower until day 25; in histamine responsive C3H mice, histological studies showed numerous and large loci of acute haemorrhagic necrosis in the tumours.

Animals↗
PubMed1981

Increased tissue histamine in tumour-bearing mice and rats.

Tissue histamine levels were studied in C3H and C57BL/6 mice bearing a methylcholanthrene-induced fibrosarcoma, in Wag rats bearing an aflatoxin B1-induced hepatoma, and in Commentry rats bearing a grafted hepatoma. Histamine levels were significantly higher (1.5 to 3 fold) in the tumour-bearing animals for ventral and dorsal skin, skeletal muscle and stomach fundus. Total histamine content was increased in the spleen. In C3H mice with McC3-1 fibrosarcoma, the excision of the tumour or its partial regression by intratumoral injections of corynebacterium parvum induced a reversion to normal values. The tumour thus appears responsible for the increased histamine levels in tissues distant from the tumour.

Animals↗
PubMed1980

Influence of histamine or dimaprit on histamine release induced by anti-ige from human whole blood.

In human subjects histamine release from whole blood by anti-IgE and studied under several concentrations of histamine and dimaprit. The results obtained in our experiments led us to question the autoregulatory feed-back mechanism postulated by BOURNE et al. [1]. Apparently this mechanism does not apply for all patients particularly at doses which resemble physiological concentrations of histamine.

Antibodies↗
PubMed1980

Histamine levels in mouse tissues of different strains: influence of sex.

The sex related difference in histamine levels of various mouse tissues was investigated in several mouse strains. In all of them the histamine levels were higher in female animals than in males. Thus experiments on histamine in mice must be carried out in animals matched for sex and strain.

Animals↗
PubMed1980

Histamine levels in mouse tissues: influence of castration.

The influence of castration on histamine levels in mouse tissues was investigated in Swiss mice. Only in female mice castration led to a significant decrease in the histamine content of dorsal and ventral skin, skeletal muscle and kidney. This effect was found 2 weeks after castration. A long-term study is being presently undertaken.

Animals↗
PubMed1976

Detection of homocytotropic human antibodies by passive sensitization "in vitro" of monkey lung tissue. II. Technique. Results on 295 patients (215 with possible drug allergy).

Anti-drug serum human IgE can be detected by passive sensitization "in vitro" of monkey lung tissue. This technique gives reproducible results which are not quantitative. It is sensible; there are no false positive results and the number of false negative results has been strongly decreased. This technique is really an anaphylaxis and IgE only are detected. The results concern the study of 215 patients which possible drug allergy. The most frequent drugs come from groups of penicillins, sulfonamides, salicylates and malonylurea derivates. In 54% of cases, anti-drug IgE have been detected.

Animals↗
PubMed1976

Lymphocyte transformation, leucocyte migration, specific IgE, IgG and IgM before, during, and after penicillin treatment without adverse reaction. A follow-up study.

This in vitro follow-up study of the penicillin-induced immune response by a well-tolerated regimen was conducted with an association of four tests: lymphocyte transformation test; leucocyte migration test; passive anaphylaxis on monkey lung tissue; and passive hemagglutination. It showed (1) that previously sensitized subjects (including IgE) tolerated the treatment by pencillin. (2) That the treatment induced either a transient positive conversion of previously negative tests or a negative conversion of previously positive tests. These in vitro findings are in accordance with previously established concepts based upon cutaneous tests and must be taken into consideration when interpretating in vitro diagnosis of penicillin allergy.

Adolescent↗