Biomedical subjects
C C Carleton
Publications and source records attributed to C C Carleton.
Commentary on the replacement of neurons in the central nervous system.
A theory is proposed by which the replacement of neurons in the central nervous system might take place. The theory is based on our present knowledge of neuroanatomy.
Intussusception secondary to aberrant pancreas in a child.
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Subacute necrotizing encephalopathy (Leigh's disease): two unusual cases.
Two unusual cases of subacute necrotizing encephalopathy are described. In one, a marked hirsutism led to a suspicion of adrenal tumor or other endocrinopathy. In the other case, there was an agenesis of the corpus callosum, the second instance in which a malformation of the corpus callosum was associated with this condition. Electron micrographs from a case of Leigh's disease showed examples of marked axonal swelling and occasional splitting of the lamellae of the myelin sheath, probably responsible for the spongy state seen under light microscopy. That such marked changes were not seen in the "internal control" tended to exclude postmortem changes. The ultrastructure and histologic structure of striated muscle appeared normal in the one case examined.
Vascular ("arteriovenous") malformations of the choroid plexus.
Two cases of arteriovenous malformation of the choroid plexus are presented, bringing the number of such cases reported to 16. One of these was successfully removed surgically after two episodes of intraventricular hemorrhage. The other was found incidently at autopsy and had produced an asymmetric hydrocephalus. Overproduction with a more forceful propulsion of cerebrospinal fluid may be the mechanism producing this effect. These lesions should be considered in cases of unexplained intraventricular hemorrhage.