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Biomedical subjects

C C Carson

Publications and source records attributed to C C Carson.

At least 127 records · Page 7Linked to original sources

Penile prosthesis in Peyronie's disease.

Many patients with Peyronie's disease suffer severe penile curvature, impotence, and respond poorly to conservative management. Sixteen patients with intractable Peyronie's disease had surgical incision of Peyronie's plaque and insertion of semi-rigid or inflatable penile implants. Patients had satisfactory results with elimination of curvature and resumption of coitus. Surgical procedures are indicated for impotent patients with Peyronie's disease who are unresponsive to conservative treatment.

Adult↗

Bacterial prostatitis caused by Staphylococcus saprophyticus.

Staphylococcus saprophyticus has been shown to be an important uropathogen in urinary tract infections in young women. Thirty-five isolates from 27 patients with staphylococci in the prostatic fluid of men with bacterial prostatitis were evaluated for the presence of S. saprophyticus. Three patients (11 per cent) with this organism were identified by novobiocin resistance (disk diffusion test), absence of hemolysis, and coagulase. These patients tended to be younger, more symptomatic, and more responsive to appropriate antibiotic therapy than those with staphylococcus epidermidis. S. saprophyticus appears to be an important pathogen in prostatic infections.

Adult↗

Seminal vesiculography: limited value in vesiculitis.

Seminal vesiculograms were performed on 44 men being evaluated for chronic perineal pain consistent with seminal vesiculitis. The vesiculograms were performed prior to antibiotic instillation into the vas deferens. Vesiculograms were abnormal in 32 of the 44 patients (73%). The most common abnormality was the presence of multiple small diverticula producing a feathery appearance of the vas deferens (64%), a finding present in only 19 per cent of patients being evaluated for infertility and 20 per cent of normal patients. Asymmetry and incomplete filling of the seminal vesicles were less common abnormalities. Seventeen of these patients had seminal vesiculectomies for persistent or recurrent pain, and 15 have been followed long enough to assess the results. The histologic examination of the excised seminal vesicles was abnormal in only 3 patients (20%), despite radiographic abnormalities in 10 (67%) and improvement after surgery in 12 (80%). Seminal vesiculography may be useful to exclude anatomic abnormalities prior to instillation, but does not appear sufficiently specific to warrant use as the primary diagnostic examination for patients suspected of having seminal vesiculitis.

Adult↗

The role of seminal vesiculography in the evaluation of male infertility.

Although most cases of male infertility are the result of primary testicular abnormalities (either maturation arrest, decreased spermatogenesis, or germinal hypoplasia), obstruction of the genital tract is a well recognized and potentially correctable cause of infertility. Seminal vesiculography is an excellent method of evaluating the male genital tract not only for obstruction but also for other structural lesions that may cause infertility. In 27 patients undergoing vesiculography as part of an evaluation of infertility, obstruction was found in 25%. Three patients (11%) were found to have nonobstructing structural lesions as a possible cause of infertility. Patients with obstructive lesions were found to have significantly lower semen volumes than those with patent outflow tracts. The continued role of seminal vesiculography in the evaluation of male infertility is discussed.

Adult↗

Long-term results with the Kaufman prosthesis.

Patients with incontinence after prostatectomy were examined for long-term results following implantation of a Kaufman prosthesis. These appears to be a dichotomy between patients who underwent implantations of the device after radical procedures versus those who had been operated upon for benign disease. Patients undergoing implantation of the prosthesis after an operation for malignant disease experienced a higher rate of complications and a lower over-all continence rate. Also, patients who underwent implantation of the Kaufman prosthesis in conjunction with the Small-Carrion prosthesis showed a 100 per cent failure rate. It appears from the data that the Kaufman prosthesis is not the long sought panacea.

Humans↗

Observations on lower urinary tract calculi in children.

Lower urinary tract calculi are rare in American children. In 20 years 26 children with bladder or urethral stones have been treated. Boys outnumbered girls by 3 to 1. All patients had urinary tract infection. Most patients harbored phosphatic calculi and had urinary tract anomalies or neurogenic dysfunction. Calculi were managed surgically in 25 children. Only 2 children suffered from recurrent vesical calculi.

Child↗

Renal growth in small kidneys after ureteroneocystostomy.

Postoperative renal growth was determined in 22 patients with unilateral atrophic kidney and vesicoureteral reflux. Atrophic kidney growth was compared to the contralateral kidney and growth tables. Significant growth of the atrophic kidney was observed in 68 per cent of the patients after reimplantation. Ureteroneocystostomy enhances growth in atrophic kidneys and is important in salvaging renal function.

Adolescent↗

Evaluation of women with chronic voiding discomfort.

Many investigators have focused on the female urethral syndrome and its causes. The origin remains enigmatic, but the benign course of this condition is well established. We evaluated 105 patients with urethral syndrome and analyzed the necessity for a complex urologic workup. The lack of significant findings on these studies suggests that the cost effectiveness of radiographic and invasive studies cannot justify their continued use.

Adolescent↗

Prognosis of patients with stage D1 prostatic adenocarcinoma.

Of 44 patients with clinically localized prostatic adenocarcinoma and regional lymphatic metastases proved by staging pelvic lymphadenectomy 11 were treated by radical prostatectomy, 20 received extended field radiation and 13 were assigned to delayed hormonal therapy. The median survival for the entire group was 39.5 months. None of the 3 treatments appeared superior in prolonging survival. Furthermore, no enhancement of disease control could be demonstrated in either treatment group. Patients with prostatic adenocarcinoma and positive nodes appear to have equivalent adverse biological potential and should be candidates for treatments designed to produce systemic effect.

Adenocarcinoma↗

Rectal ejaculation and prostatic carcinoma.

A case of carcinoma of the prostate causing fistulous communication between the rectum and the prostatic ducts is presented. The patient's initial symptoms included gradual onset of inability to ejaculate and the complaint of ejaculation per rectum. Appropriate urologic studies demonstrated a fistulous connection between the area of the ejaculatory duct and the rectum. Microscopic studies of rectal discharge confirmed that semen was exiting through his rectum. All genitourinary symptoms in patients with carcinoma of the prostate warrant thorough investigation.

Adenocarcinoma↗

Radical prostatectomy after radiotherapy for prostatic cancer.

We report on 18 patients with clinical stages B and C carcinoma of the prostate who underwent radiotherapy to the prostate, followed by radical retropubic prostatectomy and pelvic lymphadenectomy. Of the 18 patients only 2 (1 with grade 1 and 1 with grade 4 disease) had no residual local cancer at operation. Surgical morbidity was minimal in the 18 patients and only 3 patients had spread of the disease after the combined treatment. Radical retropubic prostatectomy after radiation therapy appears to be safe and effective treatment.

Adenocarcinoma↗

Evaluation and treatment of the female urethral syndrome.

We reviewed 160 patients who were evaluated for the urethral syndrome. Evaluation included urinalysis, urine culture, cystoscopy and excretory urography in all cases. Minnesota Multiphasic Personality Inventory evaluation was done in 56 patients. Of these methods only the Minnesota Multiphasic Personality Inventory had significant positive findings revealing evidence for a conversion or psychophysiological etiology. Conservation treatment was equally effective as instrumentation.

Adult↗

Definitive radiation therapy for prostatic carcinoma: Mayo clinic experience.

Primary radiation therapy for clinically localized prostatic cancer is effective and safe. Of our 147 patients treated between 1964 and 1973, 144 were evaluated 5 years after the initial date of radiation therapy. At 5 years the over-all survival rate was 80 per cent and the rate of survival free of disease was 63 per cent. More than 70 per cent of the patients were free of progression 5 years after the date of the first radiation treatment. Analysis revealed a highly significant association between tumor grade and patient survival (p less than 0.001), and between tumor grade and the interval free of disease (p less than 0.002). The relationship between tumor stage and time to progression of disease also was significant (p approximately equal to 0.01) but there was no relationship between lower stage and longer survival. Of the 142 patients who completed treatment only 20 (14 per cent) had local recurrence of the prostatic cancer after radiation therapy, representing a local control rate of 86 per cent 5 years after treatment. A few of the patients underwent post-treatment prostatic biopsy after radiation therapy. If a biopsy is done for increased prostatic induration and the results are positive adjuvant treatment is recommended. In the absence of urologic symptoms of progressive induration of the prostate gland biopsy is not instrumental in predicting the course of the cancer.

Adenocarcinoma↗

Appendicovesical fistula presenting as Klebsiella urosepsis.

Appendicovesical fistula is an uncommon condition usually occurring in boys and young men and associated with chronic urinary tract infection. Diagnosis is based on cystoscopic findings that may be confirmed by a retrograde study. Treatment by appendectomy is usually successful.

Adult↗

Bilateral nephrectomy by the posterior approach.

The experience with 94 patients undergoing bilateral nephrectomy suggests that the posterior retroperitoneal approach has lower morbidity and mortality than transabdominal procedures. In addition, the lack of transgression of the peritoneal cavity facilitates the possible use of chronic peritoneal dialysis in the future management of these patients. The circumstances in which bilateral nephrectomy is indicated are reviewed.

Adolescent↗