PubMed Health⌕ Search

Biomedical subjects

C C Christensen

Publications and source records attributed to C C Christensen.

23 records · Page 2Linked to original sources
PubMed1983

Synergism in the transformation of hamster embryo cells treated with formaldehyde and adenovirus.

Formaldehyde is a large production volume chemical widely distributed in research laboratories, industrial workplaces, and home and personal environments. Inhalation studies with formaldehyde have documented its ability to produce squamous cell carcinomas in rats. When primary hamster embryo cells were treated by gaseous exposure to formaldehyde or by incorporation into the medium, a dose-related increase in the frequency of SA7 virus transformation was produced. The length of chemical treatment and the time interval before subsequent addition of transforming virus was critical, with two-hr treatment times as the most efficient. Treatment by gaseous exposure permitted utilization of lower treatment concentrations. Determination of formaldehyde concentrations in culture media of bioassay dishes treated by this method documented that 2.2 micrograms/ml produced significantly enhanced viral transformation. Exposure of hamster embryo cells to formaldehyde by these methods produces reproducible and quantitative genotoxic effects.

Adenoviridae↗
PubMed1983

A critical evaluation of energy expenditure estimates based on individual O2 consumption/heart rate curves and average daily heart rate.

To test the applicability of indirect estimation of daily energy expenditure from average daily heart rate (HR) and individual O2-intake/heart rate (VO2/HR) regression lines in subjects with metabolic disorders, VO2/HR regression lines were determined on 2 consecutive days in 17 subjects (five healthy, five with obesity, five with untreated thyrotoxicosis, two with anorexia nervosa). Daily energy expenditure was calculated by means of the average 24 h HR. Generally, there was a high correlation coefficient for the relationship between VO2 and HR, but the slopes and intercepts varied considerably from day to day, leading to poor agreement between duplicate estimates of energy expenditures, and not infrequently to physiologically meaningless values. Further studies, comprising determination of the VO2/HR regression lines in three different body positions on 7 different days in one experienced test subject showed great variability of the VO2/HR regression lines, both in the same position and in different positions. The applied procedure seems unsuitable for metabolic studies in individual patients who engage in ordinary daily activities with low energy expenditure.

Adolescent↗
PubMed1978

Influence of pindolol (Visken) on respiratory function in 20 asthmatic patients.

The effect of a single oral dose of pindolol on bronchi was studied in a double-blind cross-over trial in 20 adult patients, most of whom had moderate bronchial asthma. A single dose of pindolol 5 mg, sufficient to cause a significant fall in heart rate and blood pressure at rest, did not produce a significant fall in the forced expiratory volume (FEV1.0). However, two patients showed marked deterioration in lung function after pindolol. A conventional therapeutic dose of salbutamol by inhalation produced a significant increase in ventilatory function relative to placebo, but it did not outweigh the bronchial effect of pindolol.

Adolescent↗
PubMedDate not supplied

Postinflammatory elastolysis and cutis laxa: report of a case with aortitis.

A 17-month-old black female manifested an acute febrile dermatosis followed by the development of cutis laxa and aortitis. The neutrophilic, acute inflammatory nature of the disease is emphasized. Pathologically, both the skin and the aorta were affected by a lesional process that shared common morphologic attributes and resulted in extensive elastolysis. However, the disease appears to differ from other entities characterized by generalized degradation of elastic fibers.

Aortitis↗