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Biomedical subjects

C C Singe

Publications and source records attributed to C C Singe.

10 recordsLinked to original sources
PubMed1993

Azathioprine combined with prednisolone or monotherapy with prednisolone in active Crohn's disease.

BACKGROUND: The role of azathioprine (AZA) in the treatment of active Crohn's disease (CD) is still controversial. This study examined whether AZA combined with standard prednisolone therapy improved the therapeutic outcome compared with monotherapy with prednisolone. METHODS: Forty-two patients with a Crohn's Disease Activity Index (CDAI) of > 150 were randomized into two groups. Both received 60 mg of prednisolone daily in a tapering regimen to a maintenance dose of 10 mg. In addition, group 1 received 2.5 mg AZA/kg body wt and group 2 received a placebo over the whole study period of 4 months. RESULTS: At the end of the trial, 16 of 21 patients (76%) in group 1 were in remission (CDAI < 150), compared with 8 of 21 (38%) in group 2 (P = 0.03). The CDAI in group 1 dropped from 290 +/- 97 (SD) to 72 +/- 84 and from 285 +/- 110 to 155 +/- 105 in group 2. The differences between activity indices in groups 1 and 2 became statistically significant after 8 weeks. The average prednisolone dose per day was 20.9 mg in group 1 and 26.7 mg in group 2 (P = 0.02). No major side effects were observed in this study. CONCLUSION: The combination of prednisolone and AZA was superior to the treatment with prednisolone alone in active CD. Patients receiving AZA showed remission more frequently, more quickly, and with lower doses of prednisolone.

Adolescent↗
PubMed1990

[The early recurrence of Crohn's disease after "curative" ileocecal resection. A prospective endoscopic and histological study].

The postoperative course of 44 patients (24 women, 20 men; mean age 31.5 [18-63] years) treated by ileocaecal resection for Crohn's disease was investigated prospectively. None of the patients received any prophylactic drug treatment during the 12-month postoperative period of observation. Recurrence of Crohn's disease was endoscopically diagnosed in 21 of the 44 patients during the 12-month period, and in 14 patients recurrence was suspected. Histological confirmation of recurrent Crohn's disease, however, was obtained unequivocally in only 11 patients, while in further 20 patients there was suspicion of recurrence. A large proportion of the recurrences was already confirmed endoscopically and histologically by the end of the third postoperative month. It is concluded that recurrences are frequent and early after a "curative" operation, raising the question of early prophylaxis with drugs.

Adolescent↗
PubMed1989

[Diversion colitis in Crohn disease. A case report and review of the literature].

A 45 year old man, suffering from Crohn's disease of the colon, and a 25 year old woman, with ileocolitis Crohn, developed a diversion colitis in the remaining distal segment of the colorectum after ileostomy. After reanastomosis, which was done 11 and 2 years later, the diversion colitis vanished spontaneously. This case report and the data in literature indicate the opinion, that reanastomosis of the distal colon should be done early after diversion, if there are no specific signs of Crohn's disease in the remaining colorectum.

Adult↗
PubMed1989

Comparison of maximal postprandial serum cholylglycine concentration with the retention of 75Se-homotaurocholic acid in ileal dysfunction.

The retention of 75Se-homotaurocholic acid (75SeHCAT) was measured in 12 healthy controls and in 21 patients with Crohn's disease and compared with the maximum postprandial rise in the serum concentration of cholylglycine (CG) in order to detect bile acid malabsorption. The retention of 75SeHCAT was lowered in all patients with inflammation or resection of the terminal ileum over a length more than 20 cm. In 64% of these patients bile acid malabsorption could also be detected by the absence of a significant rise of the postprandial CG serum level but only if the loss of the ileal function exceeded 30 cm. Although less sensitive than the 75SeHCAT retention, the CG method is simpler to apply in terms of laboratory technology and does not involve exposure to radioactivity. The CG method appears to be of use to detect bile acid malabsorption in certain cases. In the case of negatively if still bile acid malabsorption is suspected more sensitive tests such as 75SeHCAT retention should be carried out to further evaluate bile acid malabsorption.

Adolescent↗
PubMed1988

Simplified determination of intestinal protein excretion based on alpha 1-antitrypsin clearance.

Intestinal alpha 1-antitrypsin clearance in 6 healthy controls and 21 patients with Crohn's disease was measured simultaneously by two different methods. Faecal alpha 1-antitrypsin loss, determined conventionally by weight and alpha 1-antitrypsin concentration of the homogenized three day stool was compared with the faecal alpha 1-antitrypsin loss, which was calculated from weight of the three day stool sample and the mean alpha 1-antitrypsin concentration determined in three 1 g aliquots of the morning stool obtained at the three consecutive days during the collecting period. There was a significant correlation when comparing faecal alpha 1-antitrypsin loss (y = 0.96x + 10; r = 0.952) and intestinal alpha 1-antitrypsin clearance (y = 1.05x - 6.5; r = 0.974) measured by the different methods. Filling the aliquots by a standardized spoon into a vial prepared with a defined volume of solvent makes it possible to take a diluted, homogenized, and centrifuged stool sample out of the vial by the laboratory staff avoiding open faecal work up. The simplified method of measuring intestinal alpha 1-antitrypsin clearance permits to integrate the determination of enteric protein loss into routine diagnostics comparable to the faecal occult blood method.

Adolescent↗