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Biomedical subjects

C C Tijssen

Publications and source records attributed to C C Tijssen.

At least 73 records · Page 4Linked to original sources
PubMed1991

Prognostic significance of conjugate eye deviation in stroke patients.

We prospectively studied the prognostic significance of conjugate eye deviation in 80 patients with acute stroke and compared the 3-month mortality and disability of these patients to those of the Tilburg epidemiological study of stroke. Mortality of patients with conjugate eye deviation was higher (41%) than for the general stroke population (34%), but this difference was not statistically significant (p less than 0.179). Looking at mortality and disability together, we found the outcome of patients with conjugate eye deviation to be significantly worse (p less than 0.001). Deviation of the eyes occurred more frequently to the right (65%) than to the left (35%). In the patient group with eye deviation to the left, mortality was significantly higher (64%, p less than 0.001) than in the group with eye deviation to the right (25%); only two patients of the former group (n = 28) could return home. Compared to the Tilburg epidemiological study of stroke, the group with eye deviation to the left did significantly worse, both for mortality alone (p less than 0.001) and for mortality and disability together (p less than 0.001). The group with eye deviation to the right did significantly worse only for mortality and disability together (p less than 0.01). Our results indicate that conjugate eye deviation is a prognostic factor for poor short-term mortality and disability in stroke patients, especially when the eyes are deviated to the left.

Cerebral Hemorrhage↗
PubMed1991

Conjugate eye deviation: side, site, and size of the hemispheric lesion.

Conjugate eye deviation (CED) is a well-known sign that occurs rather frequently in stroke patients. To study the lateralizing and localizing value of this sign, we investigated prospectively 78 consecutive patients presenting with CED due to a hemispheric lesion. CED occurred more frequently after right-sided hemispheral damage (64%). The lesions in the right hemisphere were located predominantly in the subcortical (fronto-) parietal region and the internal capsule; the lesions in the left hemisphere were larger, covering the entire fronto-temporo-parietal area. In the majority of patients there was no direct involvement of the frontal eye fields on either side. The results indicate that a lesion at different sites within the circuit between the inferior parietal lobule and frontal eye fields, and their projections to the superior colliculus or paramedian pontine reticular formation, can be responsible for CED. The right-left asymmetry is probably related to cerebral asymmetry for directed spatial attention.

Adult↗
PubMed1989

[Glossopharyngeal nerve neuralgia: not just a sore throat].

In this article we describe six cases of glossopharyngeal neuralgia. The characteristic attacks of lancinating pain in throat, ear and tongue can be accompanied by symptoms such as coughing, hoarseness, stridor and fainting. These symptoms can also occur without the pain, which may lead to frequent misdiagnosis and unnecessary investigations. The drugs of choice are carbamazepine, phenytoin and lithium. Persisting symptoms may require an operation.

Adult↗
PubMed1989

Spinal epidural hematoma due to a vertebro-epidural hemangioma.

We present a patient with a spinal epidural hematoma (SEH), caused by a vertebro-epidural hemangioma (VEH). A VEH has been rarely reported as a cause for a SEH and it was remarkable that the VEH was located several vertebrae above the actual hematoma. This emphasises the need for extensive spinal angiography at different levels. The VEH was treated successfully with embolization.

Adolescent↗
PubMed1989

Intracranial cavernous angiomas: diagnosis and therapy.

The authors reviewed the case histories of 10 patients with intracranial cavernous angiomas treated from 1985 till 1987. Two patients are described in detail and are illustrated by CT scan, MRI scan and angiography. The diagnostic and therapeutic problems of intracranial cavernous angiomas are discussed.

Adult↗
PubMed1988

Ataxia telangiectasia in a brother and sister at older age.

In general ataxia telangiectasia is a disease of childhood leading to severe ataxia in the first decade and death in adolescence. We present a brother and a sister with the characteristic features of ataxia telangiectasia at the age of 43 and 44. They are still in reasonable good health, despite their relative old age. This unusual manifestation of ataxia telangiectasia will be discussed with emphasis on clinical and genetic aspects.

Adult↗
PubMed1987

Octavus nerve neurovascular compression syndrome.

The octavus nerve neurovascular compression syndrome is a neuropathy of the 8th cranial nerve caused by vascular compression. The clinical, neurophysiological and therapeutic aspects of this syndrome will be discussed on the basis of 10 patients.

Adult↗
PubMed1987

Neuromuscular investigations in retinitis pigmentosa.

Five patients with primary pigmentary dystrophy of the retina (retinitis pigmentosa) were tested on the integrity of their neuromuscular system. Clinical, electrophysiological and biochemical abnormalities were not found. A skeletal muscular biopsy was performed and histochemical, electron-microscopical and biochemical investigations were carried out. Only aspecific or minimal abnormalities were found. The mitochondrial functioning was especially explored and was found intact. Skeletal muscle examination is of no use in the study of retinitis pigmentosa.

Collagen↗
PubMed1986

Anterior ischemic optic neuropathy: sense and nonsense in diagnosis and treatment.

In 15 consecutive patients with AION the cause was found to be giant-cell arteritis in 3 cases and was thought to be local arteriosclerosis of the posterior ciliary arteries in 12 cases, in spite of rheumatic factors which were found initially. In 87% of cases symptoms or factors indicating generalised arteriosclerosis were found. In one case before the AION cilioretinal emboli had been found. It is reported that the second eye is affected after a varying interval of time in +/- 50% of cases. In our material the arteriosclerotic form of AION occurred bilaterally in +/- 40% of cases with an interval varying from a few days to 5 years. The average interval for this form of AION is 3 years. Cerebral angiography was of no help in tracing the cause of the AION. A fluorescein angiogram is often made too late to show the characteristic circulatory disturbance in the peripapillary choroid and is usually not necessary. Therapy should be started immediately, with large doses of corticosteroids in all cases of AION, until biopsy of the temporal artery proves negative or the ESR is practically normal. Hypertension and diabetes should be treated adequately as protection for the other eye in the arteriosclerotic form of AION. In addition long-term anticoagulant therapy should be considered: a prospective study into this aspect has been started.

Aged↗
PubMed1986

Locked-in syndrome associated with ocular bobbing.

Locked-in syndrome together with an ocular bobbing phenomenon was observed in a 41-year-old man, an association which has not been reported earlier. Computerized tomography demonstrated an infarction of the medio-ventral portion of the pons. The patient survived and is still alive ten months after the onset of the disease with severe neurological deficit.

Adult↗