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Biomedical subjects

C C Tse

Publications and source records attributed to C C Tse.

At least 19 recordsLinked to original sources
PubMed1999

Anatomic pathology image capture using a consumer-type digital camera.

Low-cost, high-quality consumer-type digital cameras are now on the market. They can be used for taking photomicrographs by simply placing the camera over the eyepiece of a conventional light microscope and pressing a button. Similar techniques can be used for capturing digital images through various types of viewing instruments. The quality of the digital images obtained is surprisingly high. With this low-cost approach, the uses of digital imaging in the author's anatomic pathology department have widely expanded.

Analog-Digital Conversion↗
PubMed1996

Handling and clinical performance of a glass ionomer sealant.

PURPOSE: To compare the handling and 6-month clinical performance of an experimental resin-modified glass ionomer cement (K-512 = Fuji III LC) with that of a light-cured resin-based sealant (Delton Opaque) when used as a pit and fissure sealant in 15-27 year old subjects. MATERIALS AND METHODS: Seventeen patients with 65 cement and 55 resin-based sealants were recalled after 6 months for clinical examination and color photographs. RESULTS: Sealant retention failures requiring retreatment were 74% for the glass ionomer cement sealant and 11% for the resin-based sealant, with one instance of fissure caries being found for each material. The resin-modified glass ionomer cement sealant showed a slight darkening from its initial placement, and was also more difficult to handle than the resin-based sealant.

Adolescent↗
PubMed1993

Mallory's bodies in placental site nodule.

We report two cases of placental site nodule in which Mallory's bodies were found in the intermediate trophoblasts constituting the lesion. Mallory's bodies are known to occur in hepatocytes and pulmonary alveolar cells in a wide variety of conditions, and represent abnormal cytoplasmic aggregates of cytokeratin intermediate filaments. Their occurrence outside the liver and lung is exceptional. In the present cases, they were immunoreactive for both low- and high-molecular-weight cytokeratins. Since high-molecular-weight cytokeratin is not normally expressed in intermediate trophoblasts, the formation of Mallory's bodies appears to involve aberrant expression of cytoskeletal proteins.

Adult↗
PubMed1993

Biliary adenofibroma. A heretofore unrecognized benign biliary tumor of the liver.

Benign biliary tumors of the liver are uncommon. In this report, we describe a distinctive biliary tumor of 7-cm diameter occurring in the right lobe of the liver of a 74-year-old Chinese woman. The lesion, characterized by a complex tubulocystic nonmucin secreting biliary epithelial and an abundant fibroblastic stromal components, is distinct from other well-recognized biliary lesions. A number of unusual features are focally present, namely, intraluminal bile concretions, apocrine-like epithelial change, acute inflammation, and granuloma. The tumor shows a striking resemblance to Meyenburg's complex (MC), but the large size of the lesion and the absence of any typical MC in the background liver are exceptional for the latter. Its expansile growth, possession of mitoses, and foci of epithelial tufting and cellular atypia favor a neoplastic process. Previous reported cases of adenomatous neoplastic transformation of MC are dissimilar. We therefore conclude that this is a hitherto unrecognized biliary tumor that may be yet another neoplastic form of MC and propose the designation biliary adenofibroma. The course appears benign, but malignant epithelial transformation may supervene if the lesion is left untreated.

Adenofibroma↗
PubMed1992

Perineurioma: an uncommon soft tissue neoplasm distinct from localized hypertrophic neuropathy and neurofibroma.

Perineurial cells, which normally surround the nerve fascicles within a nerve, can be distinguished from Schwann cells by their immunoreactivity for epithelial membrane antigen (EMA) and lack of reactivity for S-100 protein. We report two cases of perineurioma, a tumor composed exclusively of perineurial cells and distinct from other nerve sheath tumors. The first case involved a deep, soft-tissue mass of the neck, and the second involved a tumor located in the infraclavicular subcutaneous tissue. Both tumors were well circumscribed. Histologically, they were hypocellular and composed of spindle cells possessing elongated nuclei and bipolar, wavy, slender, strikingly elongated cytoplasmic processes, disposed in a background of collagen in the form of short bundles and whorls. In the first case, there were frequent calcospherites and remnants of a small nerve at the periphery. The spindle cells stained for EMA but not S-100 protein, chromogranin, neuron-specific enolase or Leu-7. Ultrastructurally, they possessed long cytoplasmic processes with incomplete basal lamina and occasional pinocytotic vesicles. Axons were not identified. Review of the literature shows that genuine perineuriomas are rare, and most cases reported as such are merely examples of localized hypertrophic neuropathy, a mononeuropathy characterized by fusiform swelling of a nerve, usually in the extremities. The involved segment in localized hypertrophic neuropathy contains distended fascicles composed of whorls of perineurial cells and fibrous tissue entrapping residual axons, probably representing a hyperplastic reaction to nerve damage. The term perineurioma should be reserved for the neoplasm composed only of perineurial cells and presenting as a soft tissue tumor.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1992

Hepatic angiomyolipomas with a deceptive trabecular pattern and HMB-45 reactivity.

We report two cases of giant hepatic angiomyolipoma with a prominent component of epithelioid smooth muscle cells exhibiting a distinctive trabecular arrangement. These cells possessed peripherally vacuolated and centrally condensed hyaline cytoplasm. The nuclei were eccentrically placed in the cytoplasm. Immunohistochemically, they expressed HMB-45 intensely in the central condensed cytoplasm and actin in a perimembranous fashion. Staining for desmin, myoglobin and vimentin was negative. HMB-45 may prove to be a sensitive marker for angiomyolipoma with epithelioid cells. Hepatocellular carcinoma and other hepatic tumours with polygonal clear cells can be readily distinguished by these means.

Adult↗
PubMed1992

Liver changes in reactive haemophagocytic syndrome.

Hepatomegaly and deranged liver functions are common findings in reactive haemophagocytic syndrome (RHS). We report the findings of 12 fatal cases of RHS in which histological materials of the liver are available for study. The underlying diseases of these patients included lymphoma/leukaemia (6 cases), disseminated undifferentiated carcinoma of the ovary (1 case), disseminated nasopharyngeal carcinoma complicated by tuberculosis (1 case), adenovirus pneumonia (1 case), pneumococcal pneumonia (1 case), typhoid fever (1 case), and possible drug intoxication (1 case). Ten patients had involvement of the liver by the underlying disease process which contributed to the marked hepatic derangement. Non-specific reactive hepatitis, sinusoidal dilatation and steatosis resulting from systemic or local effects of the associated diseases and the haemophagocytosis also added to the high incidence of liver abnormalities. A diffuse Kupffer cell hyperplasia with haemophagocytosis is characteristic of the syndrome, as all the cases showed increased numbers of bland-looking histiocytes within the hepatic sinusoids and haemophagocytosis which was moderate to marked in 8 cases and mild in 4. Thus the finding of Kupffer cell hyperplasia with prominent haemophagocytosis in liver biopsy is indicative of an element of RHS and warrants clinical monitoring. Differential diagnoses of haemophagocytosis in liver are also discussed.

Adolescent↗
PubMed1992

Solitary necrotic nodule of the liver: parasitic origin?

AIMS: To report further cases of solitary necrotic nodule of the liver and to study its nature. METHODS: Seven nodules were retrieved from 4000 necropsy and surgical liver specimens coming to light over the past five years. All of them satisfied the diagnostic criteria of solitary necrotic nodule: a solid lesion with a central necrotic core and a hyalinised fibrotic capsule containing elastic fibres. Their clinicopathological features were reviewed. RESULTS: The nodules were incidental findings at surgery or necropsy in four men and three women whose ages ranged from 48 to 79 years (mean 63.7 years). Four were found in the right lobe and three in the left. Six were subcapsular and only one deep in the parenchyma, with sizes ranging from 0.3-2.5 cm. Each of them was solitary, well demarcated, and round to oval with a firm, whitish rim and a core of yellowish white cheese-like to solid material. In addition to the basic architecture, there were a number of common and undescribed histological features: presence of varying numbers of small mural vessels with intimal fibrosis and obliteration, presence of cholesterol clefts and foamy cells among necrotic material, and sparsity of inflammatory cells. In the two cases where ghosts of degenerated cells and partially preserved liver reticulin pattern were noted, worms were identified, one being Clonorchis sinensis. CONCLUSIONS: The entity is believed to be a "burnt-out phase" of a variety of benign lesions. Parasitic infestation is another possible cause, and presence of ghosts of degenerate cells, partially preserved liver reticulin pattern, cholesterol clefts and foamy cells among necrotic material are auxiliary features pointing to such an aetiology. The variation in morphological fine details reflects both the lesion's diverse pathogenesis and the fact that it can be of varying duration.

Aged↗
PubMed1992

Myxoid change in malignant lymphoma. Pathogenetic considerations.

Myxoid change is a rare phenomenon in malignant lymphoma, and its pathogenesis is not well understood. We present a case of large B-cell lymphoma of the small bowel in which myxoid change is confined to one of the regional lymph nodes involved by lymphoma. An increase of vimentin-positive mesenchymal cells in the myxoid zones compared with the nonmyxoid areas within the lymph node and a complete lack of myxoid change in the tumor occurring in other sites of this case suggest that the myxoid stroma results from some local factors (most probably tissue edema) stimulating proliferation of fibroblasts/myofibroblasts.

Aged↗
PubMed1991

Malignant lymphoma with myxoid stroma: a new pattern in need of recognition.

We report a case of malignant lymphoma in the soft tissues exhibiting prominent myxoid stromal changes and cord-like cellular arrangement, mimicking the architectural as well as cytological features of myxoid chondrosarcoma, except for the absence of tumour lobulation. The only clue to the possible lymphomatous nature of the lesion was the past history of lymphoma. Immunohistochemical studies showed that this represented a B-cell lymphoma, staining positively for leucocyte common antigen and five B-lineage markers L26, MB2, B1 (CD20), B4 (CD19) and To15 (CD22). We conclude that malignant lymphoma should not be excluded from consideration when one encounters a myxoid tumour.

Adult↗
PubMed1990

Hyalinizing trabecular adenoma-like lesion in multinodular goitre.

Hyalinizing trabecular adenoma, a recently characterized variant of thyroid adenoma, is often confused with a variety of lesions because of its unusual histological features (Carney, Ryan & Goellner 1987). We report a case of multinodular goitre in which there were several small nodules showing features of hyalinizing trabecular adenoma and peculiar nuclear rods.

Adenoma↗
PubMed1989

Microcystic meningiomas--an unusual morphological variant of meningiomas.

Nine cases of microcystic meningiomas, a distinct morphological variant of meningiomas, are reported. They are characterized by a vacuolated and myxomatous histological appearance with multiple cystic spaces lined by stellate-shaped tumour cells. Immunohistochemically, they shared a similar pattern of positive staining for epithelial membrane antigen and vimentin with other meningiomas. Their unusual histological features might lead to problems in differential diagnosis from other intracranial tumours, including schwannomas, chordomas, astrocytomas and angioblastic meningiomas.

Adolescent↗
PubMed1988

Clinical diagnosis of late temporal lobe necrosis following radiation therapy for nasopharyngeal carcinoma.

This is a preliminary report of 102 patients with clinical diagnosis of late temporal lobe necrosis after radical radiation therapy for nasopharyngeal carcinoma during 1964 to 1983. Histologic verification was available in 12 cases. All but three patients had been treated in our institute using schedules with doses larger than the conventional 200 cGy per fraction. The incidence rate was 1.03%. In our 80 patients with only one course of external irradiation, the doses to the temporal lobes ranged from 1665 to 2127 ret, or 1286 to 1778 brain tolerance unit (btu). The latent interval ranged from 9 months to 16 years. The median observation period is 33 months. The symptomatology, working diagnosis, treatment, and outcome are described. Surgery was hazardous because of the bilaterality of the involvement and exploration for mere verification of diagnosis was unjustified in typical cases. Treatment with corticosteroid achieved durable objective response in 25 (35%) of 72 patients. The importance of early detection and corticosteroid treatment is discussed.

Adult↗
PubMed1988

Mucin production in metastatic papillary carcinoma of the thyroid.

Although textbooks often state that demonstration of mucin in a metastatic carcinoma excludes the possibility of a thyroidal primary tumor, mucin recently has been reported in various types of thyroid carcinoma, particularly medullary carcinoma. The presence of mucin in papillary carcinoma has not been extensively studied, even though this tumor not uncommonly presents with lymph node metastasis. We stained 40 lymph nodes containing metastatic papillary carcinoma of the thyroid for mucin. Mucin was demonstrable by mucicarmine stain in the colloid, luminal borders, and cytoplasm in 18 (45%), 9 (22.5%), and 7 (17.5%) cases respectively; 17 cases (42.5%) were completely negative. With alcian blue staining, mucin was seen in 9 (22.5%), 9 (22.5%), and 7 (17.5%) cases; 25 cases (62.5%) were negative. Most of the cytoplasmic vacuoles were target-like, with a peripheral rim of sulfated acid mucin and a central core of neutral mucin. The psammoma bodies stained consistently with mucicarmine, alcian blue, and periodic acid-Schiff. We conclude that papillary carcinoma of the thyroid should be included in the differential diagnoses for a mucin-producing metastatic carcinoma.

Adolescent↗