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Biomedical subjects

C C Ward

Publications and source records attributed to C C Ward.

5 recordsLinked to original sources
PubMed1985

Focus of epithelial dysplasia arising in hereditary gingival fibromatosis.

The gingiva of a 32-year-old black male was biopsied for evidence of vasculitis, but instead an area of epithelial dysplasia was found. Further investigation revealed that the patient and several members of his family had hereditary gingival fibromatosis. Treatment included four quadrants of gingivectomy plus inverse bevel incisions for trimming those areas which were too thick for simple gingivectomy. Histopathologic examination of the excised tissues supported the diagnosis of gingival fibromatosis, but no other areas of epithelial dysplasia were seen. To our knowledge, this is the only reported instance of a premalignancy or malignancy arising in gingival fibromatosis, and thus there is no reason to regard the gingival disorder as predisposing to carcinoma. However, the pedigree reported here supports a previous suggestion that hereditary gingival fibromatosis is not as rare among blacks as the literature has indicated.

Adult↗
PubMed1984

Deoxyribonucleic acid output in the sputum from cystic fibrosis patients.

The deoxyribonucleic acid (DNA) content of sputum from cystic fibrosis patients was examined to establish if it was likely to be a useful indicator of worsening clinical condition. The assay was reproducible (coefficient of variation 4.2%) and added DNA could be demonstrated. Added antibiotics did not influence the result. The daily DNA content in the sputum showed similar variations to the weight, but the DNA output (content X weight/24 h) was perhaps a more sensitive indicator of clinical status. There was a weak, negative correlation between DNA output and peak expiratory flow rate.

Cystic Fibrosis↗
PubMed1978

Biodynamic finite element models used in brain injury research.

Three-dimensional finite models for the monkey, baboon, and human brains have been developed and are described. Isoparametric brick elements and membrane elements represent the soft tissue and partitioning internal folds of dura, respectively. By specifying the finite element mesh on the skull inner surface, the irregular shape of the brain is generated. Each model is subjected to the same skull acceleration to investigate response relationships between species. Important dynamic response differences are revealed by comparing the computed intracranial pressures. Experimentally derived head injury data are correlated with model dynamic responses. Using the baboon and monkey models, brain injury tests are simulated and model response measures are compared to produced injury. Using the human model, computed stresses are compared to intracranial pressures measured in cadaver impact tests.

Animals↗