Biomedical subjects

C Cadarso

Publications and source records attributed to C Cadarso.

5 recordsLinked to original sources

PubMed1999

Fenofibrate decreases plasma fibrinogen, improves lipid profile, and reduces uricemia.

Plasma fibrinogen has been found to be a major cardiovascular disease risk factor. This 2-year trial was designed to assess the effect of fenofibrate on fibrinogen and, as secondary end points, on lipid profile and uric acid in patients with dyslipidemia. Eighty subjects (40 women and 40 men) were admitted to either a control or an active group. Sixty-seven (84%) had sole hypercholesterolemia, 13 (16%) subjects had mixed dyslipidemia. The effect attributable to fenofibrate was a decrease of 15% in fibrinogen, 26% in the ratio low-density lipoprotein cholesterol to high-density lipoprotein cholesterol (-20% low-density lipoprotein cholesterol, +10% high-density lipoprotein cholesterol), 34% in triglycerides (median), and 13% in uric acid (P < .0001 for all). Fenofibrate simultaneously affected hemostasis (by lowering fibrinogenemia) and lipid profile. Because fenofibrate has few adverse effects, it could be a fair option for patients who need polytherapy and do not tolerate resins or niacin. Its clinical efficacy should be tested in long-term studies to assess its real capacity to prevent cardiovascular events.

Aged↗

PubMed1998

Regression models: calculating the confidence interval of effects in the presence of interactions.

The main goal of regression analysis (multiple, logistic, Cox) is to assess the relationship of one or more exposure variables to a response variable, in the presence of confounding and interaction. The confidence interval for the regression coefficient of the exposure variable, obtained through the use of a computer statistical package, quantify these relationships for models without interaction. Relationships between variables that present interactions are represented by two or more terms, and the corresponding confidence intervals can be calculated 'manually' from the covariance matrix. This paper suggests an easy procedure for obtaining confidence intervals from any statistical package. This procedure is applicable for modifying variables which are continuous as well as categorical.

Adult↗

PubMed1998

[Detection of soluble interleukin-2 receptor in the serum of patients with non-Hodgkin's lymphoma].

BACKGROUND: Patients with non-Hodgkin's lymphoma (NHL) have increased serum levels of soluble interleukin-2 receptor (sCD25). In this study the authors investigate: a) the value of sCD25, compared to other serum markers, as tumor marker, and b) the relationship of the sCD25 with the response to therapy and prognosis. PATIENTS AND METHODS: Serum interleukin-2 receptor (sCD25) levels were measured at diagnosis in 63 patients with NHL (low-grade lymphoma 30 and high-grade lymphoma 33). RESULTS: High levels of sCD25 were found in these patients compared to a control group (median 1,757 U/ml vs 385 U/ml; p < 0.0001). Significant differences were also found between the high-grade group and the low-grade group, as a whole and within the same Ann Arbor stage. sCD25 showed a correlation coefficient higher than other serum parameters (albumin, LDH, beta 2-microglobulin, uric acid, C-reactive protein) with Ann Arbor stage and with the number of involved lymph nodes or extralymphatic organs. In the high-grade NHL, the median of sCD25 (3,000 U/ml) separates patients with differences in the overall survival (p = 0.0138) and in percentage of complete remisions (p = 0.0079). All the patients with sCD25 < or = 3,000 U/ml reached the remision. The association sCD25 > 3,000 U/ml and albumin < 3.5 g/dl selected to 5 out of 6 patients who failed induction chemotherapy, and only 2 out of 22 who reached the remision. CONCLUSIONS: The sCD25 is the best serum factor for estimating tumor burden in NHL. sCD25 level isolates or associated with albumin provides prognostic information.

Adolescent↗

PubMed1998

Depth perception in random dot stereograms is not affected by changes in either vergence or accommodation.

PURPOSE: To test the hypothesis that extraretinal cues related to vergence angle and lens accommodation are used to scale horizontal disparities for fixation distance. METHODS: Depth perception of random dot stereograms was studied in 10 healthy adult subjects with normal visual acuity by modifying retinal disparity, fixation distance, vergence angle, and accommodation. Statistical analysis was used to compare the data. RESULTS: Depth perception increased with fixation distance. The increment of depth perception persisted even when horizontal retinal disparity was kept constant. The magnitude of depth perception was independent of vergence angle. Depth perception did not vary with changes in accommodation. CONCLUSIONS: Extraretinal cues related to vergence angle and accommodation seem to be not necessary to scale horizontal disparities for viewing distance.

Accommodation, Ocular↗

PubMed1996

[3 year survival in patients hospitalized for acute cerebrovascular disorders].

For three years we studied the mortality and functional situation of all patients admitted in 1991 to the Neurology Service suffering from acute stroke with the exception of subarachnoid haemorrhage cases. We analyzed the cause of death whether directly related to the initial illness or not. Out of 134 patients admitted for acute stroke, 48 (41.02% of the 117 patients examined after excluding 17 whom we did not obtain complete information from) had died after three years. The main causes of death were directly related to acute stroke (37.5%) and pneumonia (37.5%). Death occurred mainly in the first month (79.16% of deaths). Predictive variables for mortality directly related to acute stroke during the first month include severe weakness, brain haemorrhage, dysphasia and earlier incidence of acute stroke. Variables related to higher mortality rate due to other causes in the first month were dysphasia, age and angina antecedents, whereas earlier incidence of acute stroke was associated with a lesser mortality rate for these causes, as distinct from acute stroke itself. Greater levels of weakness and sphincteral incontinence are the best predictive signs of dependency functional situation at the end of the first month and, along with diabetes, after one and three years.

Acute Disease↗