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Biomedical subjects

C Cano

Publications and source records attributed to C Cano.

At least 37 records · Page 2Linked to original sources
PubMed1983

Inhibition of wound healing by topical steroids.

A new animal model was used to study the effect of topical agents on wound healing. A weak- (hydrocortisone cream 1%) and medium-strength (fluocinolone acetonide ointment 0.025%) steroid and their vehicles were applied to full-thickness skin wounds placed on the backs of female Syrian hamsters. Wound healing was significantly retarded by both steroids when compared to their vehicles. Fluocinolone had a greater inhibitory effect than hydrocortisone.

Administration, Topical↗
PubMed1983

Follow-up of patients with prolactinomas after discontinuation of long-term therapy with bromocriptine.

The effects of bromocriptine discontinuation after a 2 year course of therapy on prolactin (Prl) serum levels and the radiological size of the sella turcica were investigated in 16 women with amenorrhoea-galactorrhoea due to prolactinoma. During therapy, all but 2 patients had normalized serum Prl levels, and 4 women with macroprolactinomas exhibited a reduction in the size of the tumour as documented by CT-scanning and tomography of the sellae. After bromocriptine withdrawal and follow-up during 2 additional years, Prl levels remained normal in 6 patients, 2 of them with microprolactinomas and 4 with macroprolactinoma. The remaining 10 women developed hyperprolactinaemia associated with amenorrhoea and galactorrhoea within 3 months after discontinuation of therapy. No tumour expansion was observed in any case during the 4 year observation period. In the present study bromocriptine treatment seemed to result in permanent cure in 6 out of 16 cases of prolactinomas; nevertheless it is difficult to justify an indefinite medical treatment since the natural history of prolactinoma remains unknown. We presently feel that bromocriptine is more appropriate than neurosurgical transsphenoidal exploration for the primary treatment of prolactinomas. Further investigation is needed before a more definitive conclusion regarding the management of prolactinomas can be reached.

Adult↗
PubMed1981

Nomifensine test does not differentiate hyperprolactinemia associated with and without radiologic abnormalities in the sella turcica.

A group of 17 hyperprolactinemic women was given 200 mg of nomifensine orally to evaluate its diagnostic potential to discriminate between tumors and nontumorous hyperprolactinemia. The nomifensine suppressive effect on prolactin serum levels was not significantly different between patients with or without enlargement of the sella turcica. A control group of 5 women with normal prolactin levels exhibited a nomifensine suppressive effect below 65% of the baseline prolactin level, which was significantly different from that in the hyperprolactinemic group. In conclusion it is confirmed that the nomifensine test provides no value in the early diagnosis of the prolactinoma.

Adenoma↗
PubMed1977

Spectrofluorometry of free and protein-bound plasma tryptophan.

We report a rapid, simple, and sensitive spectrofluorometric procedure for total serum or plasma tryptophan. Plasma deproteinization, tryptophan extraction, and pH optimization are all carried out with a buffered cellulose/ethanol reagent. The fluorescence is measured at an emission wavelength of 350 nm, on excitation of 290 nm. Tryptophan fluorescence relative to concentration is linear up to 50 mg/liter. The high precision, evidenced by a between-run coefficient of variation of 3.1%, negates the need for duplicate analysis of samples. Analytical recovery of tryptophan from plasma up to 50 mg/liter is 90-100%. We observed no significant difference between values for tryptophan in serum and plasma from the same individual. Assay of up to 32 samples requires 60 min. Commonly used anti-depressants have no detectable effect on tryptophan determination by this procedure.

Humans↗
PubMed1977

Removal of an endogenous antigen from an antibody to increase its effective affinity constant, as illustrated by triiodothyronine assay.

Antisera to triiodothyronine were shown to contain large quantities of the hormone, well in excess of normal circulating concentrations. Extracting the triiodothyronine from the antiserum with alkaline ethanol yielded an antibody of increased affinity. Use of this antibody in a radioimmunoassay resulted in a fourfold increase in sensitivity as compared with the unextracted material.

Antibodies↗
PubMedDate not supplied

[Unusual cause of ileal occlusion: a coconut bezoar].

A coconut phytobezoar was detected in the distal ileum of a 4-year-old boy, admitted for suspected appendicitis. While persimmon or citrus fruit ingestion has been previously reported as cause of phytobezoar intestinal occlusion, it is the first time that coconut pulp is described to cause ileal obstruction in children. No predisposing factor as previous gastric surgery or Meckel's diverticulum was present. The bezoar was successfully milked past the ileocecal valve into the right colon.

Bezoars↗