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Biomedical subjects

C Cantrell

Publications and source records attributed to C Cantrell.

17 recordsLinked to original sources
PubMed1998

Imaging of placental vasculature using three-dimensional ultrasound and color power Doppler: a preliminary study.

OBJECTIVE: To assess placental vasculature using color power Doppler and three-dimensional ultrasound techniques. DESIGN: A prospective study was performed in patients to correlate visualization of placental vessels in vivo with known anatomy. SUBJECTS: Fourteen normal patients and one patient with intrauterine growth restriction were recruited to the study. METHODS: Vessels were assessed with regard to, first, the number of vessels seen within the placenta, second, the branching pattern of the vessels within the placenta, third, the number of vessels seen along the surface of the placenta, and, last, the number of vessels seen in the maternal circulation. RESULTS: Our results show that the placental vessels seen with this technique correlate well with known anatomy. A progressive increase in the number of intraplacental vessels and the number of vascular branches observed was seen with increasing gestational age. Volume data review using three orthogonal planar images had two distinct advantages. First, they could be obtained from orientations not possible using two-dimensional ultrasound alone, and, second, they could be viewed in conjunction with volume-rendered images to allow for referencing and identification of specific vessels. Volume-rendered images were valuable in allowing the observer to acquire an improved overall understanding of placental anatomy. They also assisted the observer in following the continuity of vessels as they wrapped around and twisted through three-dimensional space. Stereo viewing was helpful in distinguishing overlapping vessels. CONCLUSIONS: Our study showed that sonographic volume imaging combined with color power Doppler imaging methods allowed for individual vessels in the placenta to be identified, both in the fetal and maternal circulations.

Arteries↗
PubMed1991

Experimental borderline lepromatous leprosy with intraneural erythema nodosum leprosum in a mangabey monkey (Cercocebus atys).

A sooty mangabey monkey (Cercocebus atys) was inoculated with Mycobacterium leprae and developed borderline lepromatous leprosy and intraneural erythema nodosum leprosum. Previously studied mangabeys have developed only disseminated lepromatous leprosy without reactions. This case broadens the spectrum of leprosy seen in experimentally inoculated animals and further characterizes the nonhuman primate model of leprosy.

Animals↗
PubMed1987

Effect of 9-(1,3-dihydroxy-2-propoxymethyl)guanine and recombinant human beta interferon alone and in combination on simian varicella virus infection in monkeys.

Treatment of viral infections with combinations of antiviral agents may permit administration of reduced doses of either or both drugs. Lowered doses may reduce associated toxicity. Intravenous administration of substantial doses of either human recombinant beta interferon (rHuIFN-beta) or 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG) prevents development of simian varicella virus infection in African green monkeys. Daily doses of 2 X 10(6) U of rHuIFN-beta/kg inhibited clinical disease in monkeys inoculated with simian varicella virus, and doses of DHPG between 20 and 60 mg/kg per day were necessary for similar antiviral effects. Intravenous administration of combinations of rHuIFN-beta and DHPG permitted an approximately 100-fold reduction in the effective dose of rHuIFN-beta and a 10-fold reduction in the effective dose of DHPG. Analysis of data relating to viremia by using the method of the median-effect principle showed the combination of rHuIFN-beta and DHPG was strongly synergistic in treatment of this infection.

Acyclovir↗
PubMed1987

Haematology of Mystromys albicaudatus.

Haemograms were determined for 90 Mystromys, 3-24 months of age, to establish normal values and to evaluate the influence of age and gender. Males over 6 months of age had higher red blood cell counts, packed cell volumes and haemoglobin levels than females of the same age. The haemograms of females 3-5 months old resembled those of males. Age and gender did not cause detectable differences in leucocyte numbers in animals over 6 months old.

Animals↗
PubMed1987

Craniosynostosis in two African green monkeys.

Multiple craniosynostoses were found in two infant African green monkeys. The bones of the calvariums were overlapped and fused at all the cranial sutures with resulting pressure necrosis of the cerebral cortices. The cause of the craniosynostoses is unknown, but the two infants were born within 15 days of each other and had the same father, suggesting either exposure to a teratogen or a genetic etiology. The overlapping of the cranial bones is unlike craniosynostosis in humans.

Animals↗
PubMed1986

Activity of 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodouracil against simian varicella virus infections in African green monkeys.

The fluorinated pyrimidines 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodouracil (FIAU) and 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-methyluracil (FMAU) are highly effective inhibitors of herpesvirus infections in vitro and in vivo. This report is concerned with an evaluation of their activities in African green monkeys (Cercopithecus aethiops) infected with simian varicella virus, a herpesvirus closely related to human varicella-zoster virus. Oral or intravenous administration of FIAU at 50 mg/kg per day as divided doses beginning 48 h after virus inoculation prevented the development of evidences of clinical infection. Oral treatment with FIAU at 30 mg/kg per day deferred as late as 7 days after virus inoculation modified the course of the disease. When treatment was started 48 h after virus inoculation, daily doses of FIAU as small as 1 mg/kg inhibited development of infections; daily doses of 0.2 mg/kg were ineffective. At the latter dose FMAU prevented development of clinical disease, suggesting that it was more active than FIAU. No signs of FIAU toxicity were observed, with the single exception of an early but transitory elevation in aspartate aminotransferase activity in serum.

Administration, Oral↗
PubMed1984

Investigation of antiviral activity of 1-beta-D-arabinofuranosylthymine (ara-T) and 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil (BV-ara-U) in monkeys infected with simian varicella virus.

1-beta-D-Arabinofuranosylthymine (ara-T) and 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil (BV-ara-U) were shown to have antiviral activity in vitro and in vivo against simian varicella virus. Both compounds successfully prevented clinical disease caused by inoculation of African green monkeys with simian varicella virus, eliminating the development of rash and substantially suppressing viremia. Ara-T treatment was effective by either intraperitoneal or oral routes of administration and BV-ara-U was active by both oral and intramuscular routes. Ara-T, however, was associated with the appearance of marked signs of neurotoxicity. Histologic examination of brain tissue demonstrated chromatolysis and pyknosis of neurons and pyknotic nuclei in glial cells. The neurologic impairment persisted in affected monkeys. This observation of central nervous system toxicity in monkeys is in contrast to studies in mice and rats where high doses of ara-T by multiple routes of administration were nontoxic. No apparent toxicity was observed in monkeys treated with BV-ara-U.

Animals↗
PubMed1983

Causes of death of infant rhesus and squirrel monkeys.

The necropsy records of 144 infant rhesus monkeys and 38 infant squirrel monkeys that died during a 2-year period at the Delta Regional Primate Research Center were reviewed for causes of deaths and other clinically important findings. Bronchopneumonia, enteric diseases, and Streptococcus pneumoniae infections were the most frequent causes of death in infant rhesus monkeys. Trauma was the most frequent cause of death in squirrel monkeys less than 1 month old and bronchopneumonia was the most frequent cause of death in older squirrel monkey infants.

Animals↗
PubMedDate not supplied

Older adults' attitudes toward suicide: are there race and gender differences?

Suicide among older persons in the United States is a major problem that has increased dramatically during the past decade. Little is known about older nonsuicidal adults' attitudes toward suicide. The purpose of this study was to identify attitudes of older persons toward suicide and to explore the relationship of race and gender to attitudes toward suicide. The Suicide Attitude Vignette Experiences for the Elderly (SAVE-L) scale, which consists of 16 vignettes, was used to measure empathy toward suicidal people and agreement with suicidal actions as portrayed in 16 vignettes. The sample consisted of 54 low-income, inner city residents, aged 65 or older. Participants reported a moderate level of empathy with suicidal behavior (M = 2.82 on a 5-point scale) and a low level of agreement with suicidal actions (M = 1.31 on a 5-point scale). There were no differences in empathy toward suicidal people nor in agreement with suicidal people's actions based on race (African American or White) or gender; nor was there a significant interactional effect of race and gender on attitudes toward suicide.

Black or African American↗