Biomedical subjects
Publications and source records attributed to C Caratero.
The ultrastructure of the Artemia cyst and larval organism was investigated. The morphology of the blastomere and of the cell organelles was described. Investigations showed the presence of two mitochondria populations: one located in the cytoplasm, the other one embedded inside the yolk platelets. Relations between yolk and mitochondria are more obvious when considering the first steps of embryonic development.
Effects of U.V. irradiation, 3,600 erg/mm2, administrated at a low dose rate, over 75 mn at the very beginning of the cell cycle, were investigated in Tetrahymena pyriformis. Irradiation results in mitotic activity changes, followed either by cell death or cell survival with subsequent normal division activity. Nucleolar fusion, possible intracytoplasmic extrusion of nucleolar aggregates and particular pictures of nucleologenesis are described. Simultaneous cytoplasmic lesions can contribute to the delayed death of Tetrahymena after U.V. irradiation.
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The control of chronic pain through transplantation of chromaffin cells has been reported over the past few years. Analgesic effects are principally due to the production of opioid peptides and catecholamines by chromaffin cells. Clinical trials have been reported with allografts consisting of whole-tissue fragments implanted into the subarachnoid space of the lumbar spinal cord (14,19,36). In the present study, allogeneic grafts were successfully used to control chronic pain in two patients over a period of 1 yr based on patient reported pain scores, morphine intake, and CSF levels of Met-enkephalin. Macroscopic examination at autopsy located the transplanted tissue fragments in the form of multilobulated nodules at the level of the spinal axis and cauda equina. Immunocytochemical microscopy showed neuroendocrine cells are positive for chromagranin A (CGA), and enzymes tyrosine hydroxylase (TH) and dopamine-beta-hydroxylase (DbetaH). The results suggest that there is a relationship between analgesic effect, Met-enkephalin levels in CSF, and the presence of chromaffin cells surviving in spinal subarachnoid space.