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Biomedical subjects

C Cardon

Publications and source records attributed to C Cardon.

13 recordsLinked to original sources
PubMed2001

Management of pseudoaneurysm of the ascending aorta performed under circulatory arrest by port-access.

Pseudoaneurysms of the ascending aorta following previous thoracic surgery pose a difficult surgical management problem. In this report, we present a case of a patient with aortic insufficiency and a pseudoaneurysm of the ascending aorta at the site of a previous anastomosis. The particularity of this case is in the atypical use of Port-Access technology (Heartport, Redwood City, CA) to overcome surgical concerns [1].

Aged↗
PubMed2001

[Effect of aortic valve replacent for aortic stenosis on cervical arterial blood flow].

Aortic stenosis is known to modify initial upstroke time (IUT) of velocity in peripheral arteries and carotid velocities. The authors conducted a prospective study in 30 patients scheduled for aortic valve replacement for aortic stenosis. The goal was to establish postoperative correction of carotid flow disorders. In the preoperative period, a positive correlation (p < 0.01) was observed between IUT and mean pressure gradient, and a negative correlation (p < 0.02) between IUT and aortic valve area. Post-operatively, the authors observed a large decrease (p < 0.0001) of IUT, and higher (p < 0.05) systolic peaks of velocity (PSV) in all studied arteries. In this article, the authors confirmed the few previous studies which described preoperative velocity modifications in aortic stenosis population, but they also described for the first time their postoperative correction. Therefore, identifying these patterns of peripheral circulatory alterations is important and underestimation of carotid stenosis, currently estimated preoperatively, must be avoided.

Adult↗
PubMed2000

Bilateral carotid dissection and factor V mutation: a second case.

A young woman 38 years of age underwent Doppler ultrasonography following the spontaneous appearance of cervical pain causing loss of sleep. The examination revealed bilateral dissection of the internal carotid arteries, confirmed by supraaortic arteriography. Two successive CT scans showed no cerebral lesions. A thrombosis of the great saphenous vein was recorded as the only vascular event in her medical history. Thrombophilia was assessed following discovery of the dissection, and upon examination a heterozygotic mutation of Factor V Leiden was revealed. This observation is the second case of carotid dissection occurring in a subject presenting a factor V mutation. At the present time, however, there are no results to justify the assumption of a direct link between these two pathologies.

Adult↗
PubMed1999

Endoscopic coronary artery bypass grafting with the aid of robotic assisted instruments.

OBJECTIVE: The development of endoscopic coronary artery bypass grafting has been limited because of poor visualization and increased technical difficulties in carrying out operations through ports. We investigated whether the use of robotic assisted instruments could minimize these difficulties. METHODS: After a period of technical development and training on cadavers (n = 8) with the Intuitive Surgical system (Intuitive Surgical, Inc, Mountain View, Calif), the first clinical application in coronary artery surgery was performed in 4 male patients (mean age 59 +/- 6 years) with the indication of grafting the left internal thoracic artery to the left anterior descending coronary artery. Robotic assisted 3-dimensional endoscopes and instruments were introduced into the left side of the chest through 3 intercostal ports. The Heartport system (Heartport, Inc, Redwood City, Calif) was used for arresting the heart during the anastomosis. RESULTS: In 2 patients, the harvesting of the left internal thoracic artery was completed endoscopically with robotic assisted instruments and the anastomosis to the left anterior descending artery was performed through a minithoracotomy with conventional instruments. In 2 other patients, the entire operation was completed endoscopically with robotic assisted instruments. Early postoperative coronary angiography demonstrated the patency of the grafts in all cases. At 6-month follow-up, all patients were free of symptoms. CONCLUSIONS: Robotic assisted instruments make endoscopic coronary bypass possible and open a new era in minimally invasive surgery.

Anastomosis, Surgical↗
PubMed1998

[Computer assisted open heart surgery. First case operated on with success].

The recent development of less invasive intracardiac surgery using small incisions and videoscopic techniques allowed an evaluation of the advantages and limitations of this new approach. Among the limitations was the increased difficulty of the surgical technique when using long instruments through small incisions and ports. We investigated whether computer assisted surgical instruments might bring a solution to this problem. Among the existing systems, we selected the Intuitive System because of two original features. It provides a stable, magnified, three dimensional view of the operating field at a console where the surgeon is seated to operate, and it uses computer assisted instruments having the same dexterity and range of motion as the hand. After 10 months of active work to adapt this system to intracardiac surgery, the first open heart operation using computer assisted instruments was carried out on a 52-year-old woman presenting an aneurysm and a large defect of the atrial septum. The patient was extubated 8 h after the operation, returned to her room 16 h later and was discharged from the hospital 8 d post-operatively with normal heart function and no residual shunt. This preliminary experience showed that computer assisted cardiac surgery is feasible and may open new and promising directions in open heart surgery.

Cardiac Surgical Procedures↗
PubMed1998

[Treatment of false aneurysm of the ascending aorta under circulatory arrest and the Port-access system].

Pseudo-aneurysms of the ascending aorta after thoracic surgery are rare and pose a problem of surgical strategy with respect to the approach, the myocardial protection and type of repair. The authors have solved the problem by using a new technology, the Post-Access TM system, which, by simply introducing a catheter into the femoral artery, allows endoaortic clamping, the administration of cardioplegic solution, and the drainage of the left heart chambers. The system was used with a good result for treating a pseudo-aneurysm of the proximal anastomosis of a bypass between the ascending aorta and the innominate artery, limiting the duration of circulatory arrest and reducing blood loss.

Aged↗
PubMed1996

[Pre- and intraoperative management of heparin cross hypersensitivity. Apropos of a case].

A patient with a Starr prosthetic heart valve for 13 years developed chronic idiopathic thrombocytopaenic purpura and a highly probable crossed allergy to heparin. As the valve needed to be replaced, cardiopulmonary bypass surgery was undertaken associating heparin with lioprost and Aprotinine. In this type of situation, aggregation of control platelets by the patient's plasma in the presence of unfractionated heparin and of low molecular weight heparin justifies the use of powerful antiplatelet agents such as lioprost which was associated with Aprotinine for its platelet protective effects. This original combination allowed successful cardiopulmonary bypass surgery under unfractionated heparin under excellent conditions with minimal blood loss. This case underlines the value of this approach for cardiopulmonary bypass surgery in patients with heparin-induced thrombocytopaenia.

Adult↗
PubMed1986

[Evidence of apparent vasopressin and oxytocin peptides in the brain of the leech Rhynchobdelle Theromyzon tessulatum (O.F.M.)].

Vasopressin- and oxytocin-immunoreactive cells have been demonstrated in the brain of the leech Theromyzon tessulatum. A mapping of their localization in the different compartments of the brain has been undertaken. The cells immunohistochemically identified have been compared to previously described cell types defined by classical staining methods for neurosecretory material. Preliminary results obtained with high performance liquid chromatography confirm the presence in brain homogenates of substances with chromatographic properties similar to that of vertebrate nonapeptides. The possible role of these vasopressin- and oxytocin-like substances in osmoregulation is discussed.

Animals↗
PubMed1982

[Are cephalic regeration and clitellogenesis controlled by the same neurohormone in the lumbricid, Eisenia foetida?].

The factor which inhibits cephalic regeneration has previously been partially purified. It is a peptidic substance (molecular weight approximately 2 000). On the other hand, the factor responsible for clitellum turgescence is found in the same fractions as the peptidic inhibitory factor. After preparative electrophoresis at pH 3.9, both factors coexist in fraction C, biologically active (Fig. 1 and Table I). After HPLC, fraction D inhibits the cephalic regeneration and keeps clitellar structures (Fig. 2 and Tables II and III). The clitellogenic factor is hydrolysed by proteolytic enzymes. Thus, this factor is peptidic like the cephalic regeneration inhibitor (Table IV). Fraction D is not completely purified (Fig. 3). However, it is likely that both factors are one single neurohormone comparable to neuropeptides found in vertebrates.

Animals↗
PubMed1981

[Purification of the brain hormone of Nereis diversicolor and Perinereis cultrifera (Annelida:Polichaeta) by high-pressure liquid chromatography (HPLC)].

Five thousand brains inhibiting gametogenesis in Nereis diversicolor and Perinereis cultrifera were extracted with cold methanol, giving a micromolecular fraction containing the whole of the inhibitory activity of the brains. This micromolecular fraction, fractionated (i) on Sephadex G 25 fine and (ii) on Sephadex G 25 superfine, gave an inhibitory peak (P 5) in organ culture. Fraction P 5, purified by high-pressure liquid chromatography, showed an area with the same biological inhibitory activity as the blank brains.

Animals↗