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C Carels

Publications and source records attributed to C Carels.

At least 37 records · Page 2Linked to original sources
PubMed2001

Skeletal and dento-alveolar stability after surgical-orthodontic treatment of anterior open bite: a retrospective study.

The aim of this investigation was to assess skeletal and dento-alveolar stability after surgical-orthodontic correction of skeletal anterior open bite treated by maxillary intrusion (group A) versus extrusion (group B). The cephalometric records of 49 adult anterior open bite patients (group A: n = 38, group B: n = 11), treated by the same maxillofacial surgeon, were examined at different timepoints, i.e. at the start of the orthodontic treatment (T1), before surgery (T2), immediately after surgery (T3), early post-operatively (+/- 20 weeks, T4) and one year post-operatively (T5). A bimaxillary operation was performed in 31 of the patients in group A and in six in group B. Rigid internal fixation was standard. If maxillary expansion was necessary, surgically assisted rapid palatal expansion (SRPE) was performed at least 9 months before the Le Fort I osteotomy. Forty-five patients received combined surgical and orthodontic treatment. The surgical open bite reduction (A, mean 3.9 mm; B, mean 7.7 mm) and the increase of overbite (A, mean 2.4 mm; B, mean 2.7 mm), remained stable one year post-operatively. SNA (T2-T3), showed a high tendency for relapse. The clockwise rotation of the palatal plane (1.7 degrees; T2-T3), relapsed completely within the first post-operative year. Anterior facial height reduction (A, mean -5.5 mm; B, mean -0.8 mm) occurred at the time of surgery. It can be concluded that open bite patients, treated by posterior Le Fort I impaction as well as with anterior extrusion, with or without an additional bilateral sagittal split osteotomy (BSSO), one year post-surgery, exhibit relatively good clinical dental and skeletal stability.

Adolescent↗
PubMed2001

Hypodontia and tooth formation in groups of children with cleft, siblings without cleft, and nonrelated controls.

OBJECTIVE: To compare the occurrence of hypodontia, dental age, and asymmetric dental development in children with cleft with their siblings and a nonsibling control group. SUBJECTS: The sample consisted of 54 children with cleft (aged 4.2 to 13.1 years), who had at least one sibling available for an orthopantomogram, 63 siblings without cleft (aged 4 to 14.9 years) and 250 controls without cleft (aged between 4 and 14.9 years). METHOD: Hypodontia, dental age, and asymmetric dental development were assessed on panoramic radiographs of the children with cleft, the siblings without cleft, and the control children without cleft. RESULTS: Both the cleft (p <.001) and the sibling group (p <.05) showed a significantly higher frequency of hypodontia and a significantly higher occurrence (cleft p <.01 and sibling group p <.001) of asymmetric dental development, compared with the control group. Only a small, but insignificant, delay in dental development could be found in the cleft and the sibling group. CONCLUSIONS; The cleft subjects with siblings showed a significantly higher occurrence of hypodontia and asymmetric dental development than the noncleft control group. This may suggest a genetic component for the occurrence of hypodontia and asymmetric dental development.

Adolescent↗
PubMed2001

Dental age estimation in Belgian children: Demirjian's technique revisited.

AIM: The purpose of this study was to evaluate the accuracy of Demirjian's dental age estimation in children in a Belgian Caucasian population and to adapt the scoring system in case of a significant overestimation as frequently reported. We selected 2523 orthopantomograms of 1265 boys and 1258 girls, of which 2116 (1029 boys and 1087 girls) were used for estimating the dental age with the Demirjian's technique. The 407 other orthopantomograms were beyond the original age limit. A second sample of 355 orthopantomograms was used to evaluate the accuracy of the original method and the adapted method. A signed-rank test was performed to search for significant age differences between the obtained dental age and the chronological age. A weighted ANOVA was performed in order to adapt the scoring system for this Belgian population. The overestimation of the chronological age was confirmed. The adapted scoring system resulted in new age scores expressed in years and in a higher accuracy compared to the original method in Belgian Caucasians.

Adolescent↗
PubMed1999

Effect of low-dose testosterone treatment on craniofacial growth in boys with delayed puberty.

Craniofacial growth was investigated in boys treated with low-dose testosterone for delayed puberty (> 14 years old; testicular volume < 4 ml; n = 7) and compared with controls (12-14 years; n = 37). Cephalometric radiographs, statural height and pubertal stage were recorded at the start of the study and after 1 year. Craniofacial growth was assessed by nine linear measurements. At the beginning of the study, statural height, mandibular ramus length, upper anterior face height, and total cranial base length were significantly shorter in the delayed puberty boys than in the controls. After 1 year, the growth rate of the statural height, total mandibular length, ramus length, and upper and total anterior face height was significantly higher in the treated boys than in the untreated height-matched controls (n = 7). The craniofacial measurements were similar in the treated boys as compared with the controls. These results show that statural height and craniofacial dimensions are low in boys with delayed puberty. Low doses of testosterone accelerate statural and craniofacial growth, particularly in the delayed components, thus leading towards a normalization of facial dimensions.

Adolescent↗
PubMed1999

Delayed dental age in boys with constitutionally delayed puberty.

It was the purpose of this study to evaluate dental age in boys with delayed puberty and to compare them with a group of normal, healthy boys. The study group consisted of eight boys with constitutional delay of growth and puberty (CDGP), older than 14 years, and with a testis volume smaller than 4 ml. The control group comprised 38 normal, healthy boys, aged between 12.4 and 14.3 years. Dental age was assessed using the Demirjian method and, on the basis of this evaluation, a dental delay score (i.e. dental age minus chronological age) was calculated in the CDGP and the control group. It was found that Demirjian's dental age assessment is a valid method for scoring dental age in Belgian boys between 12 and 14 years of age, and that CDGP boys showed a significant delay in dental development compared with normal boys (P = 0.0085). This study revealed a significant retardation in dental maturation of boys with CDGP.

Adolescent↗
PubMed1999

[Role of inheritability of tooth form, tooth malformation and tooth position].

A common technique to divide the influence of heredity and environment on certain characteristics, or pathologies is the one that uses twins. There are more or less complex techniques to carry out twin research, from which the most simple procedure consists of determining the amount of concordance of certain characteristics in monozygotic (MZ) and dizygotic (DZ) twins. In individuals who develop from one oocyte, like MZ twins, one would expect a correlation of 1.00 (or 100% concordance) purely from their gene-relation. DZ twins are the result of separate conceptions of the same parents and they thus differ as much from each other as ordinary brothers and sisters. The most recently developed twin-methodologies use path analysis and model fitting for the estimations of the heritabilities and environmental influences on certain characteristics. In this article it is tried to picture the genetic an environmental influence on tooth form, tooth position and occlusal characteristics with different genetic techniques. Generally it can be concluded that our genes are of utmost importance for tooth form and tooth malformations, but the environment has a much bigger impact on tooth position and occlusal parameters.

Environment↗
PubMed1998

Effect of testosterone replacement after neonatal castration on craniofacial growth in rats.

Neonatal castration precludes the pubertal increase in serum testosterone and reduces general and craniofacial growth in the male Wistar rat. This study aimed to determine whether exogenous testosterone given at an age beyond the normal pubertal peak restores general and craniofacial growth in male, neonatally castrated rats. The design was a randomized, double-controlled, cross-sectional trial. Male Wistar rats were assigned by weighted randomization to be either castrated early after birth (n = 35) or not (n = 15). On day 57, a 1.5-cm Silastic tube with testosterone was implanted in 18 of the castrated rats. On day 70 and day 110, body length, weight, and craniofacial growth were measured together with the weight of the prostate, and blood samples taken. The exogenous testosterone resulted in a significant increase in serum testosterone and prostate weight. All measures of general and craniofacial growth had higher mean values in the non-castrated control group than in the castrated group, while in the testosterone-implant group the mean values lay between these of the castrated animals and the non-castrated controls. Two-way ANOVA indicated a significant effect of the testosterone administration on lower-incisor growth and the size of the total skull vault.

Analysis of Variance↗
PubMed1998

Comparative effects of neonatal and prepubertal castration on craniofacial growth in rats.

The role of endogenous testosterone in the craniofacial growth of the young male rat was investigated. First, the effect of neonatal surgical castration was examined in a randomized, cross-sectional study in which male Wistar rats were allocated to be either castrated or sham-operated 4 h after birth. Then, the effect of prepubertal chemical castration was analysed in a second, randomized longitudinal study in which male Wistar rats were randomly allocated either to a control group or to two experimental groups, one injected with triptorelin at day 25 and the other injected on day 25 and on day 45. Every tenth day between 20 and 70 days of age for the first study, and between 30 and 110 days of age for the second, body length and weight were measured, cephalometric X-rays taken, and blood samples obtained. Neonatal and prepubertal castration resulted in decreased plasma concentrations of testosterone and in delayed growth of somatic and craniofacial components. The initiation, duration and magnitude of the effect was dependent on individual bones (cranial base, skull roof) and on the lower incisor, and related to the testosterone concentrations. These results suggest that testosterone effects participate in the process of normal craniofacial growth, particularly during puberty.

Aging↗
PubMed1998

A genetic study of anteroposterior and vertical facial proportions using model-fitting.

Genetic model-fitting was used to determine the heritability of anteroposterior and vertical facial proportions in twins. Lateral headplates of 33 monozygotic and 46 dizygotic twins, none of whom had undergone orthodontic treatment, were used. Five proportions, based on four vertical and five horizontal measurements, were assessed: lower facial height, anterior- to posterior-facial height, total facial height to face depth, sella-A-point to sella-B-point, and sella-upper incisal edge to sella-lower incisal edge. Reproducibility was high for all variables. Model-fitting indicated that all the facial proportions were controlled by additive genes and the specific environment. The genetic component was 71% for upper-to lower-facial height, 66% for anterior- to posterior-facial height, 62% for total facial height, and 66% for sella-A-point to sella-B-point and sella-upper incisal edge to sella-lower incisal edge.

Adolescent↗
PubMed1998

Short stature of prenatal origin: craniofacial growth and dental maturation.

Recently, children born small for gestational age (SGA) with a catch-up growth failure, have been selected for high dose growth hormone (GH) treatment. In order to gain greater insight concerning dentofacial growth and maturation of these patients, and to evaluate the possible effects of high does GH administration on facial structures, craniofacial growth and dental maturation were evaluated in short SGA persons. Seventy-seven cephalograms and orthopantomograms were available from 48 subjects, aged between 2 and 32 years. Craniofacial growth was assessed by calculating age- and gender-specific standard deviation scores (SDS) for eight linear and five angular measurements. Tooth formation was evaluated by means of a dental delay score (i.e. dental age minus chronological age). The SDS for craniofacial growth measurements for the lateral aspect showed a short anterior cranial base (-1.8 SDS), a small retropositioned mandible (< or = -1.7 SDS) and a small maxilla (-1.5 SDS); a high mandibular plane angle (+1.9 SDS) and a wide cranial base angle (+1 SDS). These findings result in a small retrognathic face with a relatively increased lower anterior face height (+1.7 SDS). In contrast to skeletal maturation, dental age was not delayed. The general growth retardation is, apparently, reflected to a differential extent within the craniofacial complex, while dental maturation appears to be a distinct process tightly linked to chronological age, and independent of general growth and bone age.

Adolescent↗
PubMed1998

Craniofacial growth and dental maturation in short children born small for gestational age: effect of growth hormone treatment. Own observations and review of the literature.

Short children born small for gestational age (SGA) may be candidates for treatment with growth hormone (GH). We examined craniofacial growth and dental maturation in a cohort of short SGA children. The general growth failure of these children is reflected to a differential extent within the craniofacial complex. As a group, these children have a small retrognathic face with a relatively increased lower anterior face height; in contrast to skeletal maturation, dental age is not delayed. GH treatment in short prepubertal SGA children leads to craniofacial catch-up growth, which is particularly pronounced in regions where interstitial cartilage is involved, the result being that the facial profile becomes less convex; dental maturation does not appear to be influenced by GH treatment. In conclusion, in short SGA children, GH treatment does not only result in an increase of body stature but also in a trend towards normalization of craniofacial growth and this without notable advancement of dental maturation.

Cephalometry↗
PubMed1997

Pain and other cardinal TMJ dysfunction symptoms: a longitudinal survey of Japanese female adolescents.

Longitudinal data were obtained for 4 years from 361 Japanese high school girls between the ages of 12 and 16. The data were analysed for the occurrence of pain and its associations with the occurrence of other cardinal TMJ dysfunction symptoms and occlusal states. It was determined that even if pain or noise or jaw-deviation symptoms appeared, those symptoms did not necessarily last thereafter. The symptoms were not persistent but rather appeared and disappeared repetitively. Those who exhibited noise during at least one of the surveys of the 4-year survey period showed a significantly higher prevalence of pain than those who did not exhibit noise at all (P < 0.05). Those who exhibited noise by the age of 13 showed a significantly higher prevalence of pain than those who exhibited noise after age 14 (P < 0.1). The temporal occurrence of pain depended upon the appearance of noise and the age at which noise first appeared. On the other hand, the occurrence of pain symptoms was not necessarily related to specific types of malocclusions, which suggests the significance of multifactorial contributions in understanding the aetiology of pain rather than the occlusal factor.

Adolescent↗
PubMed1997

Cephalometric evaluation of dento-skeletal changes during treatment with the Bionator type 1.

Treatment effects of the Bionator functional appliance were studied on the pre- and post-treatment cephalograms of 49 Class II, Division 1 cases. After treatment, a significant more ventral localization of the anterior structures of the mandible was recorded in comparison with the pretreatment situation. The proclination of the maxillary incisors was reduced. No absolute inhibitory effect on maxillary growth was observed. In this study no significant differences in the measured treatment effects on cephalometric radiographs could be demonstrated in cases with a tendency to skeletal open bite from those with a tendency to skeletal deep bite according to the criteria used in this study.

Activator Appliances↗
PubMed1997

The genetic contribution to dental maturation.

It has been established in the literature that there is a major genetic impact on tooth size (Potter et al., 1976; Corruccini and Sharma, 1985; Sharma et al., 1985), tooth morphology (Kraus and Furr, 1952; Biggerstaff, 1970), and root formation (Garn et al., 1960; Green and Aszkler, 1970). None of the studies concerning root formation, however, used the more advanced method of path analysis and model fitting to estimate genetic influence. The aim of the present study was to determine the genetic and environmental influence on dental maturation. Dental age scores were determined on panoramic radiographs of 58 pairs of twins--26 monozygotic (MZ) and 32 dizygotic (DZ)--with the method of Demirjian et al. (1973). No mirror-image effect was found between the sides of the same individual or between twin members, so dental maturation seems to be symmetrical for both left and right sides of the mandible. Correlation coefficients were significantly higher in MZ than in DZ twins, which suggests a genetic influence. Model fitting showed that the variation in dental age was best explained by additive genetic influences (A-component) (43%) and by environmental factors common to both twins (C-component) (50%). The specific environment (E-component) added only 8% to the model. The importance of the common environmental factor can be explained by the fact that twins, being raised together, share the same prenatal, natal, and immediate post-natal conditions that are of importance for the formation of the teeth.

Adolescent↗
PubMed1997

Craniofacial growth in short children born small for gestational age: effect of growth hormone treatment.

The effects of growth hormone (GH) therapy in children have yet to be completely catalogued. In the present study, the effect of high-dose GH treatment on craniofacial growth was evaluated once yearly in 21 pre-pubertal, non-GH-deficient children born small for gestational age. These children were randomly allocated to be either untreated or treated with GH at a daily subcutaneous dose of 0.2 or 0.3 IU/kg for 2 yrs. The group consisted of 12 girls and 9 boys with a mean age of 5.1 yr (range, 2 to 8 yr), bone age of 3.4 yr, and height SDS of -3.6. At the start of the study, all children showed an overall delay of craniofacial growth. This cohort of short children born small for gestational age showed a small SNB angle and a large ANB angle; all other angular measurements were within normal range. GH treatment accelerated growth in several craniofacial components, especially the posterior total facial height, the cranial base length, and the overall mandibular length. The increase of the mandibular length increased the SNB angle; no other angular measurements were affected. Age at start of treatment differently influenced the increase in posterior and total cranial base length, the increase in mandibular corpus length, and the position of the mandible in relation to the cranial base. Although GH treatment for 2 yrs led to a craniofacial growth acceleration, the position of the mandible in relation to the cranial base and the craniofacial size in lateral aspect were not normalized in the majority of the GH-treated children. No signs of disproportional growth were evidenced after 2 yrs of high-dose GH treatment. In conclusion, short pre-pubertal SGA children display an overall delay of linear craniofacial growth and a retrognathic mandible. High-dose GH treatment over 2 yrs leads to craniofacial catch-up growth, which is pronounced in regions where interstitial cartilage is involved and results in a less convex face in profile.

Age Determination by Skeleton↗
PubMed1996

The incidence of oral clefts: a review.

We have reviewed epidemiological studies on the incidence of oral clefts in several regions of the world, but mainly in Europe. The incidence ranges from 1.0/1000 to 2.21/1000. The highest incidence was in Czechoslovakia (1.81/1000), followed by France (1.75/1000), Finland (1.74/1000), Denmark (1.69/1000), Belgium and the Netherlands (1.47/1000), Italy (1.33/1000), California (1.12/1000) and South America (1.0/1000). The data from Denmark and Finland appeared to be the most reliable. All studies showed a higher incidence of cleft lip and/or palate (CL(P)) compared with cleft palate (CP). There was a predominance of girls in the CP group, while the CL(P) group comprised mainly boys. The left side was affected twice as often as the right side. Black children had a lower incidence than white children. An attempt was made in several reports to clarify the cause of oral clefts, but opinions are contradictory.

Belgium↗