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Biomedical subjects

C Carpentier

Publications and source records attributed to C Carpentier.

11 recordsLinked to original sources

Immunocytochemical localisation of NK3 receptors in the dorsal vagal complex of rat.

Using immunohistochemistry, we demonstrate that neurons of the rat dorsal vagal complex (DVC) express NK3 receptors. The density of NK3-immunoreactive neurons depends of the different subnuclei of the nucleus tractus solitarii. The efferent vagal neurons of the dorsal nucleus of the vagus nerve highly express NK3. No NK3-immunoreactivity has been detected in the area postrema. Ultrastructural examination shows that NK3-immunoreactivity is principally present at non synaptic membrane of somatic and dendritic profiles. Therefore, neurokinin B and/or other ligands may act through a process of volume transmission on non synaptic NK3 receptors in the DVC.

Animals

[Respiratory syncytial virus infections and apnea in low birth-weight infants].

Respiratory syncytial virus infection was observed in 20 infants of less than 6 months of age who had a low weight at birth, were premature and/or presented with intra-uterine growth retardation. Except for rhinitis, which was present in all cases, the symptoms were closely correlated to the gestational age: beyond 48 weeks they were those of a common lower respiratory tract infection, but below 48 weeks attacks of apnea predominated, associated or not with signs of bronchitis. The apnea was of central origin, although there was no meningo-encephalitis; it regressed completely and without sequelae within a few days. In spite of similarities (notably of terrain) with disorders of respiratory command regarded as predictive of the sudden infant death syndrome risk, such children must be considered definitely cured after the initial episode. Including them in a long-term monitoring programme does not seem to be justified.

Apnea

Lymphoplasmacytic myeloma: an immunological, immunohistochemical and electron microscopic study.

An unusual case of a light chain plasma cell myeloma is described. The disease was initially characterized by a diffuse lymphoplasmacytic bone marrow involvement, but subsequently developed widespread extramedullary metastases with anaplastic tumors in the skin which histologically resembled a "histiocytic lymphoma." Electron microscopic examination, in vitro protein synthesis of bone marrow lymphoidal cells, chemical and immunochemical studies of serum and urine proteins, and intracellular immunoglobulin study by the immunoperoxidase technique on the skin biopsy and postmortem tumor tissue demonstrated evidence for lambda light chain synthesis and secretion. These findings provide further support to the notion that the wide spectrum of diverse morphologic patterns seen in lymphoplasmacytic disorders originates from the same progenitor B-lymphoid cell. Distinguishing anaplastic variant of plasma cell myeloma from other undifferentiated neoplasms offers a challenge.

Bone Marrow