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Biomedical subjects

C Carrier

Publications and source records attributed to C Carrier.

29 records · Page 2Linked to original sources
PubMed1981

Double-blind trial of amineptine and clomipramine in the treatment of depression.

A double-blind trial was carried out in 62 depressed patients to compare the clinical efficacy and acceptability of amineptine and clomipramine. Patients were allocated at random to one or other of two treatment groups and received daily doses of amineptine ranging from 100 to 300 mg (mean 180 mg) or of clomipramine ranging from 50 to 150 mg (mean 84 mg) over a period of 6 weeks. Global assessment of response to treatment and Hamilton Rating Scale scores, assessed before and after 1,3 and 6 weeks of treatment, indicated that the two drugs appeared to be equally effective and no differences between them could be demonstrated in the analysis of the individual items or grouped items of the scale used. Measurements of ocular tone showed that there was significantly less risk of amineptine producing an increase in tone, and blood pressure and electrocardiographic investigations also underlined the greater cardiovascular tolerance of amineptine. Five (16%) of the 32 patients in the clomipramine group were withdrawn from the study because of adverse effects.

Adolescent↗
PubMed1979

[Placental chorioangioma, skin angiomas and neonatal cholestasis].

A neonate with a large chorioangioma, multiple skin angiomata and prolonged cholestasis is described. Hepatic angiomata are thought to be responsible for the cholestasis but in some reported cases the jaundice could have been due to extrahepatic biliary obstruction caused by angiomata.

Cholestasis↗
PubMed1966

[Aplasia of the umbilical artery].

A study was undertaken at St-François d'Assise Hospital, Quebec City, to determine the incidence of single umbilical artery. During a two-year period the umbilical cord was examined in 4138 consecutive deliveries. Thirty-three cases of aplasia of an umbilical artery were found, an incidence of 0.79%, which is almost identical to that reported in previous studies. Five of the 33 newborn infants with this vascular anomaly had other congenital malformations; this incidence of associated malformations is 10 times higher than that found in a control series. In studying the weight of the infants in relation to the period of gestation, it was found that many of the 33 infants with aplasia of the umbilical artery had a lower weight at birth than normal infants. The possibility that the absence of one umbilical artery might be responsible for intrauterine malnutrition is advanced by the authors.

Abnormalities, Multiple↗
PubMedDate not supplied

Quantitative analysis of T and B cell subsets in healthy and sick premature infants.

This work proposes a serial quantitative analysis of the numbers and percentages of B and T cell subsets in 104 consecutive premature infants (PI) between birth and six months of age as compared with 21 normal term infants. First, in order to ascertain the effects of perinatal distress at birth (respiratory distress, neonatal asphyxia) on certain parameters of the immune system, the PI were divided into two groups. One comprised 36 healthy preterms, the other, 68 preterms with perinatal distress. It was then shown that healthy PI differed from full-term infants by their higher absolute numbers of T cells (CD2-positive) and helper T cell subset (CD4-positive). These increases in CD2- and CD4-positive cells correlated with gestational age (GA). An increase in B lymphocytes (CD20-positive cells) was also documented but no correlation with GA could be seen. Secondly, perinatal distress was found to be concomitant with transient decrease in percentages and absolute numbers of CD2- and CD4-positive cells, particularly in PI of less than 28 weeks of gestation. The B cells (CD20- and CD21-positive cells) were not different in absolute numbers. Respiratory distress had a more discernable effect than fetal asphyxia on the immune system. Finally, no immunological parameters tested could at any time predict the occurrence of infection in PI during the first 6 months of life.

Antigens, CD↗
PubMedDate not supplied

Wheat response to differences in water and nutritional status between zeoponic and hydroponic growth systems.

Hydroponic culture has traditionally been used for controlled environment life support systems (CELSS) because the optimal environment for roots supports high growth rates. Recent developments in zeoponic substrate and microporous tube irrigation (ZPT) also offer high control of the root environment. This study compared the effect of differences in water and nutrient status of ZPT or hydroponic culture on growth and yield of wheat (Triticum aestivum L. cv. USU-Apogee). In a side-by-side test in a controlled environment, wheat was grown in ZPT and recirculating hydroponics to maturity. Water use by plants grown in both culture systems peaked at 15 to 20 L m-2 d-1 up to Day 40, after which it declined more rapidly for plants grown in ZPT culture due to earlier senescence of leaves. No consistent differences in water status were noted between plants grown in the two culture systems. Although yield was similar, harvest index was 28% lower for plants grown in ZPT than in hydroponic culture. Sterile green tillers made up 12 and 0% of the biomass of plants grown in ZPT and hydroponic culture, respectively. Differences in biomass partitioning were attributed primarily to NH4-N nutrition of plants grown in ZPT compared with NO3-N in hydroponic nutrient solution. It is probable that NH4-N-induced Ca deficiency produced excess tillering and lower harvest index for plants grown in ZPT culture. These results suggest that further refinements in zeoponic substrate would make ZPT culture a viable alternative for achieving high productivity in a CELSS.

Biomass↗