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Biomedical subjects

C Cattaneo

Publications and source records attributed to C Cattaneo.

At least 55 records · Page 3Linked to original sources
PubMed1983

Synthesis and pregnancy terminating activity of 2-arylimidazo [2,1-a]isoquinolines and isoindoles.

A series of 2-arylimidazo[2,1-a]isoquinolines (1-21), some 5,6-dihydro derivatives (22-28) and 2-phenyl-5H-imidazol[2,1]isoindole (29) were synthesized and tested for the pregnancy terminating activity in hamsters and rats. An efficient preparation of 2-arylimidazo[2,1-a]isoquinolines was devised. The isoquinolines having a 4-chlorophenyl (8), 4-bromophenyl (9), or a biphenylyl group (12) in the 2-position were the most potent compounds after subcutaneous administration. Compound 12 also showed good oral activity. The data obtained with the title compounds are compared with those of the corresponding triazolo [5,1-1]isoquinolines and isoindoles. The structure-activity relationships are discussed.

Abortifacient Agents↗
PubMed1980

Pregnancy terminating activity of a new non-hormonal anti-fertility agent, 2-(3-ethoxy-phenyl)-5,6-dihydro-s-triazole [5,1-a] isoquinoline (DL 204-IT) in the rat and the hamster. Studies on the factors affecting its activity.

The biological and the pharmacokinetic profiles of 2-(3-ethoxy-phenyl)-5,6-dihydro-s-triazole [5,1-a]isoquinoline (DL 204-IT) were explored in rats and hamsters at different stages of gestation (1st--11th day) after single and multiple (5 days) doses given in different vehicles (oily and aqueous) and by different routes of administration (s.c., i.m., i.v.). The effectiveness of the compound was demonstrated to be dependent on time of gestation, dose and vehicle. DL 204-IT did not show any pre-implantation activity. The optimal time for treatment was found to be immediately after the implantation of blastocysts. Time-course studies demonstrated that the anti-fertility action is slow and progressive with subsequent degeneration and reabsorption (rats and hamsters), or expulsion (only hamsters) of conceptuses. The biological and pharmacokinetic data show that with prolonged presence of the compound at the site of action (the utero-placental complex) lower doses are far more active in interrupting embryonal development than are much higher ones for shorter time periods.

Abortifacient Agents↗