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C Cernescu

Publications and source records attributed to C Cernescu.

At least 91 records · Page 5Linked to original sources
PubMedDate not supplied

S.S.P.E.: some clues to pathogenesis from epidemiological data.

This study is a preliminary report of the national registry of S.S.P.E. cases started in 1987 which continue early epidemiological inquiries concerning incidence in Romania during the decade 1978-1987. The analysis pointed out the high incidence of this disease: a mean incidence rate of 6.35 cases per year per million total population in the last three years. Since 1979 there has been in Romania a sharp decline in the incidence of measles induced by the initiation of compulsory vaccination. As yet this decline is not reflected in S.S.P.E. incidence. The male/female ratio varied between 1.78-3.3 according to the year of observation. The mean age at S.S.P.E. onset increased from 6-7 years at the beginning of the interval to 9.63 years in 1987. The S.S.P.E. incidence is unevenly distributed between rural and urban area and clusters of S.S.P.E. cases were observed in certain countries. Other categories of information which may be relevant to pathogenesis are discussed: immunological history, previous hospitalization and illnesses, family history, recent health problems prior to S.S.P.E. onset, education, vacations, food habits and animal-exposure history.

Age Factors↗
PubMedDate not supplied

[Different modalities for registering AIDS cases. Their importance for the European epidemic].

The high number of AIDS cases diagnosed in different European countries imposed to reconsider the opinion that European epidemic is just reflecting the American epidemic. The whole morbidity des not point out the peculiar elements of HIV infection propagation in Europe. The exponential rise of reported case number during 1987 imposes to analyse the new epidemiological situation.

Acquired Immunodeficiency Syndrome↗
PubMedDate not supplied

Immunochemical aspects of cerebrospinal fluid immunoglobulins in patients with subacute sclerosing panencephalitis.

Unconcentrated cerebrospinal fluid (CSF) samples from 50 patients with subacute sclerosing panencephalitis (SSPE) were investigated by rocket immunoelectrophoresis (RIE) against anti-human IgG sera. Two patterns of immune precipitates were observed: precipitates with exclusively cathodal and precipitates with bipolar extension. Hemagglutination-inhibition tests against measles virus antigen were performed after absorption of the CSF samples with Protein A-containing Staphylococcus aureus and treatment with 2-mercaptoethanol. The results point to different pathological significances of the precipitation line anomalies revealed by RIE, that might be relevant for some of the patients investigated.

Adolescent↗
PubMedDate not supplied

NK-sensitivity of virus-carrier target cells.

Peripheral blood lymphocytes from selected donors have a higher natural killer (NK) activity against the cells of a human erythroblastoid line (K-562) persistently infected with measles virus or herpes simplex virus type 1 than against their uninfected counterparts. The mechanisms by which persistent infection may enhance the NK activity displayed by lymphocytes are discussed.

Cell Line↗
PubMedDate not supplied

SSPE: epidemiological and serological features in a series of cases recorded between 1975 and 1984.

A number of 632 new cases of subacute sclerosing panencephalitis (SSPE) could be detected during a 10-year survey. The continuous increase in the number of annual cases suggests a possible correlation with the changes induced in measles epidemiology by the initiation of compulsory vaccination. On the other hand, a comparison of epidemiological and serological characteristics revealed significant differences between the series of SSPE cases recorded in the period preceding and in that following measles vaccination.

Age Factors↗
PubMedDate not supplied

Stability of antimeasles vaccine under the influence of some physical and chemical factors.

A study on the stability of lyophilized and rehydrated measles vaccines under the influence of temperature and light was undertaken. After rehydration there was a considerable decrease in the potency of the vaccine, even when stored at +4 degrees C-- +8 DEGREES C and in the dark. Out of the several drugs tested, the commercially available drug AS was found to have a stabilizing effect on measles vaccine infectivity.

Freeze Drying↗
PubMedDate not supplied

Persistent measles virus infection in a calf kidney cell line. Note I. Establishment of calf kidney cell lines chronically infected with measles virus and some of their biological characteristics.

Several types of persistent measles virus infection resulting in lytic infections could be established in a calf kidney cell line, according to the passage level of the substrate and to the virus strain inoculated. Persistent measles virus infection in calf kidney cells was characterized by the limited proportion of infected cells, the large amount of infectant virus, and the alteration of morphological and growth characteristics of the cells. The mechanism of this persistent infection is discussed.

Animals↗
PubMedDate not supplied

Antimeasles vaccination by natural routes--experimental background and practical consequences.

A limited number of passages (up to 10) in human diploid cells (HDC) does not lead to changes in the phenotypic markers indicating the degree of attenuation of the vaccine strains of measles virus (Schwarz, Leningrad-16, Edmonston-Zagreb). At the same time, the increase in virus titer and the acquiring of immunogenicity when administered by nonparenteral (conjunctival, nasal) routes represent the prerequisites of a convenient form of application of the measles vaccine prepared in HDC.

Administration, Intranasal↗