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Biomedical subjects

C Cernigliaro

Publications and source records attributed to C Cernigliaro.

At least 37 records · Page 2Linked to original sources
PubMed1983

[Intracoronary thrombolysis].

Intracoronary Urokinase administration was attempted in 42 patients with acute myocardial infarction. One patient died before Urokinase infusion could be started, two patients during treatment. 34 patients (83%) had total occlusion of a coronary vessel, 7 patients (17%) had a subtotal occlusion. Urokinase was administered at a rate of 10.000 IU/min in 11 consecutive patients (Group I), 6000 IU/min in 11 patients (Group II), 4000 IU/min in 11 patients (Group III), 2000 IU/min in 8 patients (Group IV). Recanalization of the occluded vessel or amelioration of the subocclusion was obtained in 36 patients (88%). 35 patients were controlled 12 days after the procedure, with coronary-angiography and left ventriculography. Patency persisted in 31 patients and successful thrombolysis was associated with significant improvement of left ventricular ejection fraction in those patients with depressed ventricular function before Urokinase treatment.

Coronary Vessels↗
PubMed1982

Intracoronary thrombolysis with urokinase in acute myocardial infarction. Effects on reperfusion and left ventricular wall motion.

Intracoronary Urokinase administration was attempted in 20 patients (mean age 56 years) during the early phase of an acute evolving myocardial infarction. One patient died before urokinase infusion could be started. Out of the remaining nineteen patients, eighteen had total occlusion of a coronary vessel; one patient, in cardiogenic shock, failed to show occluding thrombi of the vessel related to the ECG site of infarction, and died during the procedure. Urokinase was administered at a rate of 4000 IU/min in 7 consecutive patients (Group I), 6000 IU/min in 5 patients (Group II), and 10000 IU/min in 6 patients (Group III). Recanalization of the occluded vessel was obtained in 16 patients (88%). The reperfusion time was 52 +/- 33 min. No significant variation in reperfusion time was noted in the three groups of patients treated. The time elapsed between the onset of symptoms and the successful recanalization was in our patients 4.3 +/- 1.8 hours. Ventricular arrhythmias, which required treatment, appeared after reperfusion in five patients. No serious hemorrhagic complications were noted. In fourteen patients ventriculography was performed before and immediately after thrombolysis: 15 patients had the study repeated 12 days after the procedure. Patency persisted in 13 patients and successful thrombolysis was associated with significant improvement in left ventricular ejection fraction and segmental wall motion. Our data demonstrate that different doses of Urokinase can be safely and successfully used to produce intracoronary thrombolysis in the majority of patients with acute myocardial infarction.

Adult↗
PubMed1976

[Correlations between plasmatic concentrations and antiarrhythmic effect of bunaphtine (author's transl)].

Antiarrhythmic effect of Bunaphtine (1.5 mg/kg) (e.v. in 2 min) was studied in 35 patients with ectopic rhythms, both ventricular and supraventricular. Arrhythmia was checked by continuous electrocardiographic recording. Bunaphtinemia was determined by spectrophotometric method. Plasma concentration levels proved that Bunaphtine is cleared from the blood in two different stages: T1/2alpha = 0.5 min and T1/2beta = 84.7 min. Antiarrhythmic effect was observed in connection with the fast distribution phase and it was even more evident when plasma concentration fluctuated around 3-4 mg/l. Extrasystoles increased when Bunaphtine levels diminished. The minimum effective level showed fairly good individual differences. In three cases with congestive heart failure, hepatic and renal insufficiency the increase or the appearance of ventricular extrasystole was related to high Bunaphtinemia levels. Risk of toxicity seems to be related to the dose and the administration methods. Cardiac decompensation or hepatic and renal insufficiency determine more elevated and protracted Bunaphtinemia levels.

Adolescent↗
PubMed1976

[Blood bunaphthine during dynamic physical exercise and anti-arrhythmic action].

The course of bunaphtinemia during submaximal exercise was studied. To 5 patients showing the appearance or the increase of extrasystole, both ventricular and supraventricular, during ergometric test on the bicycle ergometer, bunaphtine was administered by the following method: a first dose of 0.5 mg/kg was injected endovenously in 2 minutes followed by a constant endovenous infusion at the speed of 2.5 mg/min, throughout the exercise. Doses were calculated referring to a pharmacocynetic pattern with two compartments and supposing an apparent distribution volume of 3 l/k. Resulting bunaphtinemia curves showed a steady state and were completely above the minimum effective standard throughout the test. In all patients the drug prevented ventricular arrhythmias and compared to the standard reduced the supraventricular arrhythmias by 80%.

Aged↗
PubMed1976

Influence of "Polarizing" infusions on anthiarrhythmic effects of beta-blockers.

The antiarrhythmic effect of practolol (0.30 mg/kg) was studied in 25 patients pretreated with infusion of glucose-insulin (GI) solution. GI solution showed an antiarrhythmic effect either after or before the beta-blocker with pH in normal range or compensated metabolic acidosis. GI infusion produced a metabolic acidosis and an arrhythmogenic effect in some cases. Practolol had no antiarrhythmic effect in patients with VPB and GI infusion raised metabolic acidosis.

Acidosis↗
PubMed1975

The effect of physical training on the sympathoadrenal response to exercise.

The urinary excretion of catecholamines was measured in six healthy male volunteers at rest and during a fixed amount of work before and after physical training. It was found that, although training resulted in a significantly lower heart rate during exercise, the output of catecholamines was unaltered, indicating that the total activation of the sympathoadrenal system by exercise was similar before and after training. A similar heart rate study before and after training was also made during beta-adrenergic receptor blockade. Under these conditions the heart rate during exercise was not significantly changed by training. It is suggested that physical training reduces the sensitivity of the beta-receptors of the heart.

Adult↗