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Biomedical subjects

C Chaimoff

Publications and source records attributed to C Chaimoff.

At least 37 records · Page 2Linked to original sources
PubMed1988

Amputation neuroma after cholecystectomy. A cause of intermittent obstructive jaundice.

A 43-year-old woman developed recurrent attacks of intermittent obstructive jaundice 5 years after cholecystectomy. After 6 years of recurrent attacks, an obstructive lesion was finally demonstrated, and was diagnosed at surgery as an amputation (traumatic) neuroma of the midcommon bile duct (CBD). Symptoms disappeared following surgical removal of the lesion. We review the clinical picture of this relatively rare problem, along with its diagnosis, pathogenesis, and treatment.

Adult↗
PubMed1988

Inflammatory pseudotumor of the liver.

Inflammatory lesions in the liver simulating tumor formation are rare. Eleven cases have so far been reported in the literature, most of them in recent years. We present an additional case of an "inflammatory pseudotumor" in a 17-year-old male. The inflammatory pseudotumor should be kept in mind in the differential diagnosis of hepatic space-occupying lesions.

Adolescent↗
PubMed1986

Budd-Chiari-like syndrome in Caroli's disease.

Caroli's disease was complicated by a Budd-Chiari-like syndrome as a result of enlarged lymph nodes that compressed the vena cava. Histologically the picture was compatible with "sinus histiocytosis with massive lymphadenopathy." We discuss the combination of these two rare disorders.

Adult↗
PubMed1986

The diagnostic significance of sulfated acid mucin content in gastric intestinal metaplasia with early gastric cancer.

Specimens of fifteen surgically resected stomachs with early gastric cancer were histologically and histochemically examined using Alcian blue-periodic acid-Schiff and high iron diamine--Alcian blue stains. Samples were taken from the tumor, from the gastric mucosa 3 cm from the edge, and from the resected margins. In all 15 stomachs colonic intestinal metaplastic changes were present in the tumor tissue, as well as in the adjacent 3 cm mucosa and in the distant resected margins. In all cases neutral mucin content was reduced, whereas acid nonsulfated mucin was increased as demonstrated by Alcian blue-periodic-acid Schiff staining. Furthermore, acid sulfated mucin was demonstrated by high iron diamine-Alcian blue staining in the superficial layer of the metaplastic mucosa adjacent to the cancerous lesion and in the tumor itself. Sparse foci were also found in the surgical margins. We suggest that the increased content of acid sulfated mucin and its distribution might serve as an early indicator of malignant potential of the metaplastic gastric mucosa.

Gastric Mucosa↗
PubMed1986

The influence of peritoneal closure on formation of intraperitoneal adhesions: an experimental study.

Adhesion formation to the peritoneal scar was investigated in 108 white Wistar rats which had undergone midline laparotomy under ether anaesthesia. In 92 rats a microtrauma was produced by rubbing the intraperitoneal organs with dry gauze. After this procedure in 46 rats the abdominal cavity was closed by suturing the peritoneum and fascia, and in another 46 rats the peritoneum was left untouched. In the remaining 16 rats a sham operation was performed. The rats were sacrificed after 7, 14, 30 and 60 days and adhesion formation to the peritoneal scar was studied microscopically and macroscopically. It was found that in rats in which the peritoneum layer was sutured a significantly higher amount of adhesion to scar developed. The results of the sham operation proved that the method of abdominal-wall closure is responsible for the adhesion formation to scar after laparotomy.

Animals↗
PubMed1986

Spontaneous rupture of the common bile duct.

Spontaneous rupture of the common bile duct in adults is very rare. The authors report only the 14th case in the Western literature. A 25-year-old woman had signs of peritonitis suggestive of a perforated appendix, but at operation the appendix appeared normal and a large amount of bile was found in the peritoneal cavity. A 2-mm tear was found on the anterior wall of the common bile duct. The patient recovered without complications after T-tube drainage and cholecystectomy. In this patient none of the factors thought to cause spontaneous rupture of the common bile duct were present, so the authors conclude that the case may be classified as idiopathic spontaneous rupture of the common bile duct.

Cholangiography↗
PubMed1985

Prostaglandin E2 and cyclic nucleotides in plasma and urine of colonic cancer patients.

Prostaglandin E2 and cyclic nucleotide levels were measured in plasma and urine of 14 patients with colonic cancer. The measurements were performed 1 day before and 8 days after the removal of the tumor by operation. There was no difference between the plasma PGE2 levels (in form of the 13, 14-dihydro-15-keto metabolite) before and after the operation, but they were significantly higher than the level of a control group. No differences before and after operation were found between plasma cyclic AMP (cAMP) levels, plasma cyclic GMP (cGMP) levels, urinary cAMP levels and urinary cGMP levels. All the cyclic nucleotide concentrations were within the normal range. No correlation could be found between the stage of the tumor spread and any of the substances analyzed. The conclusions are that plasma PGE2 and plasma and urinary cyclic nucleotides do not originate from the colonic tumor tissue, and that these substances cannot be used as tumor markers.

Adenocarcinoma↗
PubMed1985

The sandwich approach: irradiation-surgery-irradiation in rectal cancer. Four years' experience.

A sandwich technique of adjuvant radiotherapy was used to treat 47 patients with rectal cancer. Preoperatively, 3000 rads were given for 12 days; 300 rads per day for five days, with a two-day interruption and another five days of 300 rads per day, followed by surgery ten days later. On the basis of the histopathologic findings, 26 patients with Dukes' B2 and C rectal cancer were given 3000 rads postoperatively in the same manner as the preoperative irradiation, starting four weeks after surgery. Patients with Dukes' A and B tumors received no postoperative irradiation. The preoperative radiotherapy was well tolerated by all patients with only minimal side effects. During surgery there was no technical difficulty in removing the tumor en bloc and, in some cases, the macroscopic impression was that the tumor had actually disappeared. In most cases, microscopic examination revealed fibrotic tissue replacing the tumor. In some cases, no cancer tissues were observed. The postoperative course was uneventful, the average length of hospitalization being 14.5 days. We believe that this technique of adjuvant radiotherapy with a moderate dose of irradiation is a logical and well-tolerated approach in the treatment of rectal cancer, and patients who were inoperable before irradiation became resectable after it.

Adenocarcinoma↗
PubMed1985

Severe alterations of red blood cells from the vessels of colorectal tumors.

The RBCs from vessels supplying the tumors of 14 patients with colorectal carcinoma were examined with the scanning electron microscope. In all of them a great variety of alterations in the shape and the cell membrane were found. Erythrocytes from the vessels of healthy colonic tissue of the patients were found to have a normal appearance. Since fibrin thrombi were present in a few vessels of only six patients, the possibility that the alterations were due to mechanical trauma was not likely. This observation may serve as an additional explanation for the anemia observed in patients with colorectal carcinoma.

Adenocarcinoma↗
PubMed1985

Transformation of erythrocytes to spherocytes following incubation with malignant cells.

Incubation of erythrocytes from controls and patients with colorectal carcinoma with tumor cells, or their metabolites, caused transformation of the normally-shaped cells to spherocytes. It is assumed that abnormal metabolites produced by malignant cells affect the cell membrane inducing the subsequent appearance of spherocytes. The increased destruction of these cells by the reticuloendothelial system may serve as an additional factor for the explanation of anemia accompanying malignant diseases.

Colonic Neoplasms↗
PubMed1985

Hemostatic changes after saline infusion.

An in vitro trial was performed to detect a thrombotic tendency in patients receiving saline infusions before surgery. The following tests were performed: thromboelastography (TEG) with the three indices of the reaction time (r), clot formation time (k) and maximum amplitude (MA), and antithrombin III, which was investigated immunologically as well as by a functional test with a chromogenic substrate and an automated method. The use of these tests together with others for the detection of high-risk patients is suggested, since no single laboratory test was found to be sufficient for the prediction of thrombotic diseases.

Antithrombin III↗