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Biomedical subjects

C Chaimoff

Publications and source records attributed to C Chaimoff.

At least 91 records · Page 5Linked to original sources
PubMed1978

The effect of pH on platelet and coagulation factor activities.

After observing that lavage of the stomach with alkaline solutions has a beneficial effect on the control of gastric hemorrhage, we examined the platelet and coagulation factor activities under conditions of lower and elevated pH. The results showed that change of the pH from acidosis to 7.0 and even to slight alkalosis induces platelet aggregation, platelet calcium and serotonin release, as well as platelet factor II availability. The prothrombin and partial thromboplastin times approached normal levels, whereas the fibrinogen level did not change significantly. The results obtained may serve as an explanation for the control of the intragastric bleeding in patients treated by maintenance of their gastric pH at 7.0.

Blood Coagulation Factors↗
PubMed1978

Serum immunoglobulin changes after accidental splenectomy in adults.

Serum immunoglobulin levels were examined in a group of twelve healthy adults who underwent accidental splenectomy. Depressed mean IgM levels and elevated mean IgA levels were found in these patients as compared with the control group consisting of forty-five healthy, untraumatized volunteers. Immunoglobulin changes may have some relevance for the increased tendency to severe infections which has been noted after splenectomy.

Adolescent↗
PubMed1975

Gamma-glutamyl transpeptidase as an aid in the diagnosis of liver metastases.

Serum gamma-glutamyl transpeptidase (GGTP) activity was examined in 79 patients. Of these, 49 had diverse malignant tumors, some of which had metastasized to the liver, and 18 had benign diseases of the liver, gallbladder and bile ducts. Enzyme activity increased significantly in all but two patients in whom liver metastases were found. All but one of the patients with malignant tumors, but without liver metastases, showed normal GGTP activity. GGTP activity was elevated in all cases of jaundice. In the absence of jaundice, elevated GGTP activity is suggestive of the presence of liver metastases.

Adult↗