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Biomedical subjects

C Charupatana

Publications and source records attributed to C Charupatana.

11 recordsLinked to original sources
PubMed1988

Effect of praziquantel treatment on antibody levels and lymphoproliferative responses in patients with opisthorchiasis.

The purpose of this study was to explore alternative method(s) to monitor the efficacy of anthelmintic treatment of patients with opisthorchiasis. Therefore, in our initial attempt, we studied the changes in antibody levels and lymphoproliferative responses in O. viverrini infected patients before and 2 months after successful praziquantel treatment. The results showed that although a substantial reduction of the antibody levels occurred after such a treatment, it did not occur in all patients. In those showing reduction, the final level were still above 2 standard deviations of the normal mean value. The reduction was more profound for IgG antibody. With regard to the IgA antibody isotype, the reduction was not as marked. In contrast, IgE antibody levels in most patients not only failed to decline, but instead, showed a tendency to be elevated after praziquantel treatment. Unlike the antibody levels, there was no alteration in the lymphoproliferative response to PHA stimulation and therefore this parameter is not useful for our intended objective. It was suggested that studies of a more specific O. viverrini component may be more reliable than the current method of parasitological examination of eggs in the feces of suspected individuals.

Animals↗
PubMed1976

Immunoglobulins and antibody response in children with protein-calorie malnutrition.

The immunoglobulin levels (IgG, IgA, IgM, IgD, and IgE) were studied in 28 Northern Thai children with protein-calorie malnutrition (PCM). Of these 14 had marasmus, 7 had marasmus-kwashiorkor, and 7 had kwashiorkor. The immunoglobulin levels were measured on admission and serially during 12 weeks of treatment leading to recovery. All immunoglobulin fractions either equalled or exceeded levels seen in well-nourished urban and rural Thai children, with or without infection. There was no difference in levels of IgG, IgM, IgA, or IgD in children with marasmus when compared with those who had marasmus-kwashiokor or kwashiorkor. IgA levels were higher in malnourished than control children and returned to normal with treatment. Eighty percent of the children with PCM had detectable IgD levels while 64% had detectable IgE levels as compared to none in the control groups. Ten additional children admitted with PCM and 10 who had recovered from PCM were immunized with intradermal typhoid antigen. Within 8 days a significant increase in typhoid H antibody appeared in the recovered group, while the malnourished group demonstrated no significant increase in H antibody titer.

Antibodies, Bacterial↗
PubMed1970

Antibody responses in serum, secretions, and urine of man after parenteral administration of vaccines.

The nature of antibody activities associated with purified immunoglobulin fractions of serum, secretions (whole saliva, parotid secretion, and intestinal secretion), and urine of a volunteer after subcutaneous booster injections with rabies virus, poliovirus, diphtheria and tetanus toxoids, and typhoid-paratyphoid-cholera vaccines was investigated. The results showed that the pattern of antibody responses in these fluids differed from one antigen to another. Serum-antibody responses to killed-bacterial vaccine were associated mainly with the immunoglobulin M (IgM) component, slight activities were detected in the IgG, and only traces of activities, if any, were found in the IgA. These antibodies were primarily of the secretory IgA type in whole saliva and parotid secretion. Slight activities were also observed in the urinary IgG fraction. Responses to inactivated viral vaccine and toxoids were almost exclusively associated with the serum IgG component. Some antitoxic activities to diphtheria and tetanus toxins were noted in a low-molecular-weight urinary immunoglobulin component.

Journal Article↗