Biomedical subjects

C Cinos

Publications and source records attributed to C Cinos.

3 recordsLinked to original sources

PubMed2002

[Prostatic brachytherapy indications and technique].

Prostate cancer is an important health problem, mainly in elderly men. It is the second cause of death among men in USA ant the third at the "Registro del Cáncer de Tarragona", behind both the lung and colorectal cancer. About the 58% of the newly diagnosed cancers are localized, therefore, they have to be treated with curative intention. Radical prostatectomy is considered the gold standard treatment for organ confined prostate cancer in our country. On basis to the experience of American groups and the improvement of both, image techniques and dosimetric calculation, brachytherapy has been brought in as a new option in the treatment of localized prostate cancer. We started our program of brachytherapy for prostate cancer on May 2000. We have performed 51 procedures by now. Our protocol and the technique to perform a prostatic brachytherapy are described following.

Brachytherapy↗

PubMed1995

Cell death induced by gamma irradiation of developing skeletal muscle.

Newborn Sprague-Dawley rats were exposed to a single dose of 2 Gy gamma rays and killed from 6 h to 5 d later. Increased numbers of dying cells, characterised by their extreme chromatin condensation and often nuclear fragmentation were seen in skeletal muscle 6 h after irradiation. Dying cells decreased to nearly normal values 48 h later. In situ labelling of nuclear DNA fragmentation identified individual cells bearing fragmented DNA. The effects of gamma rays were suppressed following cycloheximide i.p. at a dose of 1 microgram/g body weight given at the time of irradiation. Taken together, the present morphological and pharmacological results suggest that gamma ray induced cell death in skeletal muscle is apoptotic, and that the process is associated with protein synthesis. Finally, proliferating cell nuclear antigen-immunoreactive cells, which were abundant in control rats, decreased in number 48 h after irradiation. However, a marked increase significantly above normal age values was observed at the 5th day, thus suggesting that regeneration occurs following irradiation-induced cell death in developing muscle.

Animals↗

PubMed1991

Total perturbation correction factor for PTW and NACP plane parallel chambers in electron beams.

The international protocols of electron dosimetry published by the Nordic Association of Clinical Physics and the Sociedad Española de Física Médica recommend the use of a total perturbation correction factor pu, pp which is constant for all plane parallel chambers. In this work we have compared the dose measured with the PTW-Markus and NACP plane parallel chambers in respect to a cylindrical one. The obtained results indicate that for the ionization chamber NACP the value of pu, pp = 1.000 +/- 0.005 is adequate while for the ionization chamber PTW the observed difference is explained by considering an individual total perturbation correction factor variable with the mean energy at depth z, Ez, as the fluence perturbation correction factor pf is usually given for cylindrical chambers.

Humans↗