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Biomedical subjects

C Cipriani

Publications and source records attributed to C Cipriani.

At least 37 records · Page 2Linked to original sources
PubMed1985

The effectiveness of glycosaminoglycans in peripheral vascular disease therapy: a clinical and experimental trial.

Thirty patients suffering from peripheral vascular disease (stage-II according to Fontaine) were included in a double-blind study aimed at assessing the efficacy of a high-dose glycosaminoglycan (GAG) (Sulodexide) both in terms of laboratory parameters, such as lipid metabolism and blood coagulation components, and instrumental procedures (strain-gauge plethysmography). Compared with the fifteen control patients (treated with placebo), the fifteen patients treated with Sulodexide showed a significant decrease in blood triglycerides and fibrinogen as well as a significantly increased HDL-cholesterol, and positive instrumental changes: at the end of treatment Peak and Rest Flow values--and consequently also Winsor's index--were significantly increased only in patients treated with Sulodexide.

Aged↗
PubMed1982

Flushing in rosacea: a possible mechanism.

Flushing in rosacea has been investigated by means of (a) pharmacological inhibition of some possible chemical mediators and (b) titration of bradykinin as a possible effector directly in the blood. Clonidine-inhibited flushing was seen in all patients (mean 45%), other drugs had poorer results. Bradykinin increased in all patients at the climax of flushing (mean 60%). These findings support the hypothesis that epinephrine promotes a bradykinin release responsible for vasodilation.

Adult↗
PubMed1979

Uptake of 67Ga-6-mercaptopurines in Morris hepatoma-3924 A.

67Ga-chloro-6-mercaptopurine and 67Ga-citrato-6-mercaptopurine complexes have been prepared and their distribution in Morris-hepatoma-3924 A-bearing rats studied. The tumour affinity of the gallium-67 compounds varies in the order: 67Ga-chloro-6-mercaptopurine greater than 67Ga-citrato-6-mercaptopurine greater than 67Ga-citrate greater than 67Ga-chloride.

Animals↗
PubMed1979

Soluble and insoluble collagen and elastin in the rat hair cycle.

Soluble and insoluble collagen and elastin were chemically evaluated in the dorsal skin of rats during the third hair cycle. Both fractions of collagen remain unchanged during anagen, while they increase considerably in the first days of telogen to drop afterwards. Elastin content gradually increases throughout anagen and falls in telogen. The authors suggest that the increasing amounts of collagen in the first part of telogen may be responsbile for the progressive block in the downwards movements of previously growing follicles into the dermis. Elastin data could be the result of a mechanical readjustment of skin to the expansion provoked by growing follicles.

Animals↗
PubMed1976

Metabolism of testosterone 4-14C in skin of castrated rats.

Testosterone metabolism was studied in the skin and preputial glands of normal and prepuberally castrated male rats during the 2nd hair cycle. In catagen-telogen the 17-beta-OHSDH of dorsal skin was higher in castrated than in control animals; 5-alpha-reductase instead, remained unchanged through out the hair cycle. Also in the preputial glands of castrated rats 17-beta-OHSDH was higher than in normal rats. So was 5-alpha-reductase. A possible direct control of a substrate, like Testosterone, and/or of a hypophyseal tropin, like prolactin, on enzymes that direct the metabolism of steroids in target tissues is conceivable.

3-Oxo-5-alpha-Steroid 4-Dehydrogenase↗
PubMed1976

Adenyl-cyclase activity in rat-hair-cycle.

In the skin of rat, during telogen phase, a high adenyl-cyclase activity coincides with maximal catecholamines content, minimal histamine level and blocking of mitoses in epithelial cells. These events suggest that in telogen the control of mitotic activity in rat hair follicles may operate through a block of G1 cells as already suggested for epidermal cells.

Adenylyl Cyclases↗