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Biomedical subjects

C Claoué

Publications and source records attributed to C Claoué.

31 records · Page 2Linked to original sources
PubMed1988

Neural spread of herpes simplex virus to the eye of the mouse: microbiological aspects and effect on the blink reflex.

This paper reports the microbiological aspects of zosteriform spread of herpes simplex virus (HSV) to the eye in the NIH strain of inbred mouse. Microbiological data support the concept of true zosteriform spread of herpes simplex virus from the inoculation site on the snout to the trigeminal ganglion, and thence to the eye. Following zosteriform spread of HSV to the eye, there is a frequent bacterial superinfection and this is associated with a typical clinical picture. Treatment of the mice with intensive systemic and topical antibiotics is able to alter the frequency with which this type of keratitis is seen.

Animals↗
PubMed1988

Epithelial cyst in the anterior chamber after penetrating keratoplasty: a rare complication.

We report the case of a 25-year-old man who had a penetrating keratoplasty for keratoconus. A year and a half after surgery a cyst was noted in the anterior chamber, which was observed to enlarge over six months. Because of anxiety about endothelial touch, it was removed surgically. Histologically the cyst was composed of stratified, non-keratinized squamous epithelium attached to loose fibrovascular tissue including islands of melanin-containing epithelial cells. This was interpreted as an epithelial implantation cyst of the anterior chamber of corneal origin attached to iris tissue.

Adult↗
PubMed1988

Preliminary data suggest a role for bacterial superinfection of a viral keratitis after zosteriform spread of herpes simplex virus to the eye of the mouse.

After inoculation of herpes simplex virus (HSV) on the snout of the mouse, spread to the eye occurs via neural pathways. The keratitis which ensued was clinically atypical for a pure herpetic keratitis, leading to a search for other causative agents. Preliminary data suggests that bacteriological super-infection of the viral keratitis occurs frequently, producing a unique experimental model.

Animals↗
PubMed1986

Informing the hospital of patients' drug regimens.

Patients who are admitted to Southampton Eye Hospital are asked to bring a form from their general practitioner with details of all drugs that have been prescribed and to bring all their current medications. We carried out a study to find out what proportion of patients were taking medicines by prescription only and how many of these were known to the general practitioner. Less than half of the forms completed by the general practitioners were correct.

Aged↗
PubMed1986

Experimental contamination of Minims of fluorescein by Pseudomonas aeruginosa.

Contamination of fluorescein solutions by Pseudomonas aeruginosa has been a concern of ophthalmologists for many years because of the severity of pseudomonas keratitis. Attempts to prevent contamination have been directed at stringent sterility control during manufacture and the introduction of single-dose disposable containers such as Minims. Deliberate contamination of Minims fluorescein with Pseudomonas aeruginosa was attempted. Under conditions likely to be met with in clinical practice the contents remained sterile. However, under extreme conditions of immersion in pure broth culture of Pseudomonas aeruginosa contamination could be achieved. The relevance of these results to clinical practice is discussed.

Disposable Equipment↗
PubMed1986

A new look at experimental herpes simplex eye disease: preliminary results of clinical disease in the NIH mouse after zosteriform spread.

Following the discovery by Tullo et al that herpes simplex virus type 1 (HSV1) can reach the eye by zosteriform spread after inoculation into the cutaneous field of the trigeminal ganglion, this model has been adapted to the NIH strain of inbred mouse. Clinical disease in the NIH mouse after snout inoculation includes skin disease, mydriasis, iritis and keratitis.

Animals↗
PubMed1978

If I were a dean.

Explore the source record for details and available documents.

Education, Medical, Undergraduate↗
PubMedDate not supplied

Resource management of cataract patients: effect of four contemporary incisions on postoperative visits required.

PURPOSE: To assess the effect of four contemporary cataract surgery incisions on the number of postoperative visits required. SETTING: Cataract service of a large free-standing eye hospital in a capital city. METHODS: This study comprised a prospective evaluation of three incisions for phacoemulsification and a retrospective assessment of age- and sex-matched patients having conventional corneal section extracapsular cataract extraction. All patients had age-related cataract. Main outcome measures were complications, best corrected and uncorrected visual acuities 6 weeks after surgery, and number of visits before discharge. Follow-up was at least 6 months. RESULTS: Patients who had small and scleral incisions had better uncorrected visual acuities 6 weeks postoperatively because they had less astigmatism. Patients who had small and scleral incisions required significantly fewer postoperative visits before discharge. CONCLUSION: A prospective assessment of the feasibility and acceptability of reduced postoperative follow-up after phacoemulsification using a scleral tunnel is required.

Astigmatism↗
PubMedDate not supplied

Resource management of cataract patients: can visual rehabilitation be achieved in three visits?

PURPOSE: To assess the feasibility and acceptability of reduced postoperative follow-up after phacoemulsification using a scleral tunnel technique. SETTING: Cataract service of a large free-standing eye hospital in a capital city. METHODS: In this pilot study, patients with age-related cataract requiring surgery were prospectively recruited to a standardized management protocol, the three-episode model, with assessment by an independent observer. Main outcome measures were number of postoperative visits, patient satisfaction, and refractive error at 2 and 6 weeks postoperatively. RESULTS: Almost 90% of patients could be managed within this model of care. Patient satisfaction was high; no patient requested further hospital visits. Mean change in refractive error between 2 and 6 weeks was 0.34 diopters (D), with a modal value of 0 D. Patients were able to obtain spectacles 2 weeks postoperatively because little change in refraction occurs over the next month. CONCLUSION: The three-episode model for the management of patients with cataract could result in significant financial savings. Such savings could be used to treat patients with cataract who otherwise would not have treatment or would have their surgery delayed.

Episode of Care↗