Biomedical subjects
C Collinge
Publications and source records attributed to C Collinge.
Treatment of complex tibial periarticular fractures using percutaneous techniques.
Open reduction and internal fixation typically is reserved for the treatment of patients with articular or periarticular tibia fractures, or other tibial injuries that are treated inadequately with intramedullary nailing. This approach can result in extensive dissection and tissue devitalization. By modifying the method of fixation, the plating of tibial fractures has been expanded using a percutaneous technique. Using this approach, the fracture is reduced indirectly and plates are placed through subcutaneous or submuscular tunnels through limited incisions. Between 1992 and 1998, 17 patients with tibial shaft fractures and associated severe soft tissue injury, were treated using a percutaneous plating technique. Followup was available in 14 patients. Six patients required bone grafting procedures for delayed union or nonunion, although four of these patients had significant bone loss related to their injury. There were no malunions. Three patients had superficial infections related to external fixator pin sites and one patient had osteomyelitis develop. Percutaneous plating of the tibia offers an alternative method for stabilizing complex fractures with severely compromised soft tissues, especially those injuries with periarticular extension. This technique is thought to cause no increase in the risk of infection or soft tissue damage and permits rapid mobilization of the limb and patient. When using this treatment for patients with significant bone loss, bone grafting should be considered.
Details of the central projections of the cochlear nerve in the hamster revealed by the fluorescent tracer DiI.
A new fluorescent tracer, DiI, may be used postmortem in perfused animals making placement in small structures such as the cochlea much less difficult. We have mapped cochlear nerve terminations in the cochlear nucleus with DiI and, using three-dimensional reconstructions, have demonstrated the topography and geometry of the cochlear input. By placing DiI in two regions of the cochlea, we have demonstrated that terminations from the cochlea form stacked sheets of inputs. If enough closely situated ganglion cells were labeled in the cochlea, a well-delineated stripe of label could be found in each section of the cochlear nucleus up to the superficial granule cell region. Here a small extension of label, separate from the stripe may represent the medial olivocochlear axons. When fewer axons were labelled in the cochlear nerve, the sheets were absent and discontinuous patches of label were found. These patches apposed rostrocaudally to form bands of label that run orthogonal to the tonotopic organization.