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C Corti

Publications and source records attributed to C Corti.

43 records · Page 3Linked to original sources
PubMed1984

Assessment of optimal dose of diuretic associated with fixed dose of beta-blocking: a new experimental model based on multiple sampling of blood pressure performed by self-measurements.

A new experimental model is presented for determining the optimum dose of 3 different doses (13 mg, 25 mg, 37 mg per day) of hydrochlorothiazide employed to enhance hypotensive effect of 200 mg/day of metoprolol in human hypertension. The model takes into account the circadian variability of blood pressure as sinusoidal function and wash-out effect as a linear trend so as to compensate for bias due to normal temporal variability.

Adrenergic beta-Antagonists↗
PubMedDate not supplied

[Diagnostic and therapeutic criteria of arterial hypertension in childhood].

Arterial hypertension (AH), either primary or secondary, is an important issue in childhood for its short- and long-term cardiovascular morbidity. Renal diseases are the most frequent causes of AH in children, but essential hypertension can also be detected early in life. It is important for blood pressure (BP) to be checked regularly (at least once every 5 years) in healthy children and adolescents and every year in those belonging to at-risk categories (family history of AH, low birth weight, obesity, etc). In children, AH is defined as BP recorded in three non-consecutive measurements with an appropriate device and cuff size > or = 95th centile for age, gender and height. Ambulatory BP monitoring is a valuable diagnostic tool and once AH is confirmed, a specific primary cause should always be ruled out (renovascular, cardiac, vascular, endocrine, pharmacologic, other). In case of border-line or significant AH (between 90th and 99th centile) a non-pharmacological treatment should be considered, whereas severe hypertension (>99th centile for height and age) will require pharmacological treatment (Diuretics, Angiotensin Converting Enzyme Inhibitors, Angiotensin Receptor Blockers, beta - and Calcium blockers).

Child↗
PubMedDate not supplied

The maternal 24-h blood pressure (BP) profile as a predictor of fetal distress.

No mention is made of any aspect of BP bioperiodicity, among current clinical criteria for diagnosing pregnancy-related hypertension. The abnormal BP, based on a single unqualified measurement, is accepted and utilized as a clinical feature to identify pregnancy at risk. Systolic, diastolic and mean arterial blood pressure were measured every 15 min for 24 h in 5 women (2 non pregnant clinically healthy subjects, 1 clinically healthy subject in her third trimester of pregnancy, 1 presenting mild and 1 severe toxiemia, also in their third trimester of pregnancy) by an automated BP recording apparatus (Dynamap). All variables, analyzed by the single cosinor method, exhibited statistically significant circadian rhythms. A high amplitude could nullify the time-unqualified usual range. The change in circadian amplitude precedes an overt mesor hypertension and constitutes a tool for earlier detection of fetal distress.

Adult↗