PubMed Health⌕ Search

Biomedical subjects

C Cosentino

Publications and source records attributed to C Cosentino.

34 records · Page 2Linked to original sources
PubMed1982

Synthesis and biological evaluation of some 5-aryl-2-amino-1,3,4-oxa(thia)diazoles.

Three series of 5-aryl-2-amino or 2-amino substituted 1,3,4-oxadiazoles (IV-XVIII) were prepared together with the corresponding series of the analogous 5-aryl-2-amino-1,3,4-thiadiazoles (XIX-XXXIII). The purpose of this work is two-fold: to study their pharmacological action in relation to the substituents bound to the positions -2 and -5, and to observe whether the isosteric substitution of the oxygen of he oxadiazolic nucleus with the sulfur leading to a thiadiazolic nucleus causes any activity variation. The AA. report and discuss the results obtained studying the antifungal as well as the antiinflammatory and antipyretic activity of the synthetized compounds.

Analgesics↗
PubMedDate not supplied

[Becker's myotonia in Peru].

INTRODUCTION: The word myotonia was used for the first time by Strümpell in 1891. Diseases associated with this symptom are called myotonias. They are classified on the basis of their clinical features in: congenita myotonia, paramyotonia congenita, myotonic dystrophy and Schwartz-Jampel syndrome. Becker's myotonia is a generalized congenita nondystrophic myotonia transmitted as an autosomal recessive trait and caused by allelic mutation of the gene encoding the chloride channel CLC-1 of the skeletal muscle fiber surface membrane, localized on chromosome 7q35. At the present time, nondystrophic myotonias are referred as channelopathies. CLINICAL CASE: We describe a case of generalized myotonia in a Peruvian young male, descending of Europeans, without familial history. CONCLUSIONS: We discuss his clinical symptoms, laboratory and electrophysiologic findings, differential diagnosis, and response to the treatment with carbamazepine. We report the first case of Becker's myotonia in Peru.

Adolescent↗
PubMedDate not supplied

[Chin tremor in a peruvian family].

INTRODUCTION: Chin tremor is an uncommon hereditary autosomic dominant disorder, characterized by involuntary, episodic, and repetitive movements involving chin muscles, stimulated by stress. It was first described by Massaro in 1894 like geniospasmo . The most reported cases are from Europeans or Americans families. CLINICAL CASE: A 53 years old man with chin tremor since childhood. CONCLUSIONS: We report the first Peruvian family with chin tremor without European nor American ascendancy with six affected members in four generations.

Chin↗
PubMedDate not supplied

[A case of Isaacs' syndrome associated with dextrocardia].

INTRODUCTION: Isaacs syndrome is a disorder of unknown etiology characterized by muscular rigidity, cramps and myokymias. Described by Isaacs in 1961 and called by him as continuous muscular activity syndrome. There are few reports in Latino american countries. CLINICAL CASE: A 31 year-old man with sustained muscular contractions in lower limbs and diffuse myokymias since he was eighteen-year old. Dextrocardia was disclosed on clinical examination. CONCLUSION: We report the case of a patient with Isaacs syndrome and dextrocardia.

Adult↗
PubMedDate not supplied

[Pseudoathetosis after medullar and pontine hemorrhage].

INTRODUCTION: Athetosis is a slow and purposeless involuntary movement which changes in frequency, severity. The term pseudoathetosis is used when this movement is associated with proprioceptive sensory impairment. CLINICAL CASE: A 63 year old man developed right medulla and pons hemorrhage and presented loss of proprioception in left hemibody and athetosis movements in left hand. CONCLUSION: We report a case of pseudoathetosis associated with loss of proprioceptive sensation.

Athetosis↗