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Biomedical subjects

C Cotta

Publications and source records attributed to C Cotta.

7 recordsLinked to original sources
PubMed2004

[Late metastases of malignant choroidal melanoma after curietherapy: two case reports].

PURPOSE: The technical advancements now provide conservative treatment of choroidal melanoma. The course of the disease remains marked by the metastases that usually set in within 3 years. The aim of this paper is to report two unusual cases of hepatic metastases of choroidal melanoma that set in 11 and 18 Years after curietherapy. METHODS: A 40-year-old woman and a 50-year-old man presented with T2 and T3 choroidal melanomas and were treated by cobalt plaque. The tumors decreased within the year and the patients were monitored every 3 months for 5 years. RESULTS: Metastases set in, respectively, 11 and 18 years after treatment. DISCUSSION AND CONCLUSION: These two observations show that the metastases had already spread at the moment of diagnosis and that the cell doubling time of the melanoma was very long. These findings indicate the difficulties in monitoring patients with choroidal melanoma.

Adult↗
PubMed1998

Genetic forma recombination in permutation flowshop problems.

This paper analyzes different representations for permutation flowshop problems. This is done using forma analysis to assess the quality of these representations with respect to makespan optimization. Classical recombination operators are studied and empirically evaluated in this context. It is shown that the best operators work on representations in which absolute positions of tasks are relevant. Subsequently, some new operators operating on these representations are proposed. These new operators are designed to exhibit specific properties regarding implicit mutation and forma transmission. Their performance is shown to be competitive with traditional operators.

Adult↗
PubMed1990

[Efficacy of the electrocardiographic diagnosis of left ventricular hypertrophy on the basis of gender].

STUDY OBJECTIVE: To determine the efficacy of electrocardiographic criteria of Left Ventricular Hypertrophy (RVL greater than 11 mm, SVE3 + RVL greater than 20 mm in females and greater than 28 mm in males, SV1 + RV6 or SV2 + RV5) in hypertensive patients according to sex. DESIGN: Retrospective study. Gold standard M mode echocardiography. SETTING: Pulido Valente Hospital Department of Cardiology (Lisbon). PATIENTS: 56 hypertensive patients (age 55.1 s.d. 11.6), 27 females and 29 males, with LVH by echocardiographic Left Ventricular Mass Index (LVMI) greater than 110 g/m2 in woman and greater than 134 g/m2 in men, respectively 10 and 19 patients. The LVMI was calculated by the formula of the American Society of Echocardiography modified by Devereux. RESULTS: The LVMI was smaller in females than in males (P = 0.007). The Cornell Criteria had the greatest efficacy in woman and the Sokolow criteria satisfactory efficacy but in man. The electrocardiogram (1 of the 4 criteria positive) had low diagnostic efficacy in woman. CONCLUSIONS: We concluded that echocardiogram is the best non-invasive diagnostic tool of Left Ventricular Hypertrophy in hypertensive females and is necessary to adjust and choose the electrocardiographic Left Ventricular Hypertrophy criteria according to sex.

Adult↗
PubMed1990

[Arrhythmia in chronic respiratory insufficiency].

Ventricular arrhythmias are frequent in chronic pulmonary disease. Hypoxemia, right ventricular enlargement, associated left ventricular dysfunction and iatrogenic factors are potential determinants of the density and complexity of these arrhythmias. Its prognostic meaning in chronic pulmonary disease and its relationship with the elevated prevalence of sudden cardiac death in these patients, are not well known. Meanwhile, the therapeutic anti-arrhythmic strategy is dominated by the correction of the etiologic factors, namely continuous oxygen therapy which decreases ventricular arrhythmia and prolongs survival. Holter 24 hours monitoring is a useful diagnostic tool in management of these patients.

Arrhythmias, Cardiac↗