PubMed Health⌕ Search

Biomedical subjects

C Cotuţiu

Publications and source records attributed to C Cotuţiu.

At least 19 recordsLinked to original sources
PubMed1995

[Malignant transformation of odontogenic cysts].

Five out of 4,172 operated maxillary cysts (3 developed within the maxillary and 2 in the mandible) presented a malignant change of epithelium. In all these 5 cases histology demonstrated a transition from normal to cancerous epithelium. The overall percentage of malignant change was of 0.12%, with 0.077% for non-keratinized epithelium lining odontogenic cysts (3 cases) and 0.65%, that is 8 times higher, for keratinized ones (2 cases). Keratinization of cystic epithelium and chronic inflammatory lesions were the main risk factors.

Adult↗
PubMedDate not supplied

[Carcinosarcoma of the corpus uteri--a case report].

Sarcomas account for fewer than 5% of all cancers of the uterine corpus. We present the last classification of The International Society of Gynecology Pathologists for pure sarcomas and also for mixed epithelial-nonepithelial tumors of the uterine corpus. The paper concerns with the study of a case of carcinosarcoma, treated in the III-rd Clinic of Gynecology from Iaşi. This morphological diagnostic represents the most common epithelial-nonepithelial tumor affecting the uterus. Immunohistochemistry with EMA confirms the theory of the combined tumor with a unique origin.

Adnexa Uteri↗
PubMedDate not supplied

[Adenocarcinoma of an eccrine sweat gland--the diagnostic problems].

Eccrine adenocarcinomas rarely present a clinical aspect that suggests a malignancy. We present a case of an adenocarcinoma of an eccrine sweat gland with a moderate degree of differentiation associated with a verruca vulgaris (papilloma). The verrucous tissue contained a large number of melanocytes giving the macroscopical aspect of a malignant melanoma. The light microscopy elucidated the problems of diagnosis. The immunological status may be responsible for this association between a benign tumour of the epidermis with a viral histogenesis and the carcinoma of an eccrine sweat gland.

Adenocarcinoma↗
PubMedDate not supplied

Complex investigation of Graves'-Basedow disease: case report.

This paper relate a patient case, age 42, female sex, which was complex immuno-morphologically investigated, on thyroid fragments, surgically obtained. The patient was previously diagnosed with Graves'-Basedow disease; the relapses after conventional therapy, orientated the case for surgical treatment--subtotal thyroidal resection. Using polyclonal and monoclonal antibodies, we may confirm that the disease is fully active. Graves'-Basedow disease is the most common form of autoimmune thyroiditis, responsible for the majority of the cases of hyperthyroidism, affecting young women. It was suspected, many years ago and recently demonstrated that the hyperthyroidism is involved in the development of the autoimmune response, by increasing the immune reaction of the organism. Some effects of the antithyroid drugs are mediated by the decrease of the specific stimulator antibodies (long-acting thyroid stimulator), commonly found in Graves'-Basedow disease.

Adult↗
PubMedDate not supplied

Adenomyxoma of eccrine sweat gland--case report.

Although eccrine adenoma is usually situated on the distal portions of the extremities, we present a case localized in the vicinity of a mammary gland near axilla. The clinical diagnosis was of a mammary fibroadenoma with associated apocrine type of adenomere, supported by a myxomatous stromal tissue. The diagnosis was of an eccrine adenomyxoma. We continue with a review of the problems of microscopical differential diagnosis.

Adenoma, Sweat Gland↗
PubMedDate not supplied

[Prognosis and treatment of membranous glomerulonephritis-a 5-year prospective study].

UNLABELLED: The aims of the study were to describe the clinical, pathological and biological features of membranous GN and to prospectively evaluate the relationships between individual negative prognostic factors--type of therapy and outcome. Between 1993-1998, 13/150 (8.7%) consecutive patients with renal biopsy had membranous GN (M = 62%, age = 42.5 +/- 14.5 years). Main (major) findings in these patients were: asymptomatic proteinuria--23.1%, heavy proteinuria (> 10 g/day)--33.3%, microscopic hematuria--53.8%, increased plasma creatinine levels--33.3%, hypertension--23.1% cases. 60% of the patients with nephrotic proteinuria had an underlying cause (infection, malignancy, immune-mediated systemic diseases). 40% of the patients with nephrotic proteinuria had 0 or less than 2 negative prognostic factors (without any of the recognized severe morphological changes). The following differentiated treatment protocols were applied: no treatment for asymptomatic proteinuria (group A), i.v. methyl-prednisolone boluses + prednisone 1 mg/kgc/day 3 months for those patients with few negative prognostic factors (group B), and steroids (as above) + cyclophosphamide (2 mg/kgc/day 3 months) or the Ponticelli regime in patients with important risk factors (group C). Outcome after a median follow-up period of 24 months was: complete remission in all cases from groups A + B (with only one exception were the underlying cause was breast malignancy); in group C in 75% of the subjects a complete or partial remission (proteinuria < 1 g/day) was obtained. Only one case progressed to chronic renal failure. There were no secondary effects from corticoids or immunosuppressive therapy. CONCLUSIONS: In membranous GN treatment should be tailored to the presence and type of negative prognostic factors. Even in high-risk patients combined steroids and immunosuppressive therapy determines a favorable outcome in 75% of the cases, without severe adverse effects.

Adult↗
PubMedDate not supplied

[ANCA's- approach, advantages, limits].

OBJECTIVES: The aim of this paper is to present the experience of the Laboratory of the Department of Histology in establishing the presence of ANCAs, in cases which cover an extremely large and diverse pathological area. The investigations were made following the request of some clinical medical services, ANCAs being a complementary exam, with an important role in the orientation and/or confirmation of the diagnosis. METHODS: There were investigated 77 cases with clinical diagnoses ranging in the connective tissue diseases field, mainly SLE and vasculitides, and in the renal diseases field, mainly glomerulonephritis. There was performed an indirect immunofluorescence technique with a personal method, involving the usage of blood smear instead of neutrophils concentrate, human anti-IgG monospecific fluorescent conjugate and serum from the patients. RESULTS AND DISCUSSIONS: There was obtained a comprehensive survey of the presence of ANCAs in the study group. The interpretation of the results was completed within the general clinical background and in association with the physician. There is discussed the significance of the data in comparison with the literature. CONCLUSIONS: The ANCAs research may become a monitoring method of different cases, offering therapeutic and prognostic efficiency elements.

Adolescent↗
PubMedDate not supplied

Histological aspects of the pulmonary territory as seen in an experimentally ovalbumin induced inflammation in guinea pigs.

The microscopic morphology of the respiratory territory was investigated on sections of pulmonary tissue and bronchioalveolar lavage liquid (BAL) that were stained with Giemsa, PAS and trichrome solutions. As a result of the induced pathological conditions, the following histological images were encountered: normal histological aspect of the bronchoalveolar territory was seen in the groups nebulized with 0.9% NaCl or sensitized after i.p. administration of ovalbumin (OA); macrophage cells influx in both tissue samples and BAL in animals nebulized with OA; after sensitization with OA followed by nebulization with OA, the same sequence of events as in atopical asthma was reproduced, including loss of epithelial structure and the appearance of mast cells and basophils in the alveolar territory. Hydrocortisone hemisuccinate, used to treat asthma attacks, causes a similar histological aspect as in the untreated group. Cells with intact basophilic granules were seen in the hypersensitized group under ketotiphen protection.

Animals↗
PubMedDate not supplied

[New data about ITO cells].

Ito cells (the fat-storing cells) are stellate cells located in the space of Disse. They can be selectively stained with gold chloride, but their distinguishing feature in routine histological preparations is the presence of multiple lipid droplets in their cytoplasm. Ito cells have the capacity to accumulate exogenously administered vitamin A as retinyl esters in lipid droplets. The quantity of vitamin A, which is stuck into Ito cells, decreases progressively in liver injury, like chronic alcohol intake. Also, the fat-storing cells are the principal cellular source of collagen and other extracellular substances in normal as well as fibrotic liver. Liver injury is followed by an increase in the number of the fat-storing cells.

Adipocytes↗
PubMedDate not supplied

Renal pathomorphologic aspects in cirrhogenic diseases of the liver.

The pathomorphogenesis of renal lesions in the course of cirrhogenic diseases of the liver was studied on a human and experimental material. The development of membranoproliferative glomerulopathy, of tubular lesions, interstitial reactive infiltrates and sclerosis processes in the advanced stages of cirrhosis were observed. An important role in the determining of these lesions was played by immunologic perturbations in the entire organism.

Adolescent↗
PubMedDate not supplied

[Granular cells of the hepatic capillary sinuses--receptors].

Pit cells or hepatic natural killer (NK) cells represent an organ-associated NK cell population. They are situated in liver sinusoids and exert high spontaneous cytotoxic activity against tumor cell lines and may act as a primary defense barrier to metastasing tumor cells and to virus infections. Pit cells express two types of receptors on their cell membrane. One type activates NK cell killing (NCR or natural cytotoxicity receptors, as NKp46, NKp44, NKp30, NKG2D) by recognizing ill-defined molecules on target cells. The second type of receptors inhibits the lytic pathway by recognition of self class I MHC molecules and are represented by KIR or killer cell Ig-like receptors, as KIR2D, CD94/NKG2. Pit cells express on their cell membrane and other type of molecules as CD2, CD54, CD11a/CD18 and are CD3 negative.

Animals↗